Eng Hooi Tan
A5018241648- Global Cancer Incidence and Screening
- Health Systems, Economic Evaluations, Quality of Life
- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- Medication Adherence and Compliance
- Colorectal Cancer Screening and Detection
- Pharmaceutical Practices and Patient Outcomes
- Economic and Financial Impacts of Cancer
- Statistical Methods in Clinical Trials
- COVID-19 epidemiological studies
- Male Breast Health Studies
- Vaccine Coverage and Hesitancy
- BRCA gene mutations in cancer
- Machine Learning in Healthcare
- Genetic factors in colorectal cancer
- HER2/EGFR in Cancer Research
- Clinical Reasoning and Diagnostic Skills
- Kawasaki Disease and Coronary Complications
- Drug-Induced Hepatotoxicity and Protection
- Influenza Virus Research Studies
- Sepsis Diagnosis and Treatment
- Advanced Causal Inference Techniques
- Colorectal Cancer Treatments and Studies
- SARS-CoV-2 and COVID-19 Research
- Bipolar Disorder and Treatment
University of Oxford
2020-2025
Nuffield Orthopaedic Centre
2020-2025
Office for National Statistics
2021-2022
National University Health System
2016-2021
National University of Singapore
2009-2021
National University Hospital
2019
Purpose: The COVID-19 pandemic profoundly affected healthcare systems and patients. There is a need to comprehend the collateral effects of on non-communicable diseases. We examined impact short-term survival for common solid tumours, including breast, colorectal, head neck, liver, lung, oesophageal, pancreatic, prostate, stomach cancer in UK. Methods: This was population-based cohort study electronic health records from UK primary care Clinical Practice Research Datalink GOLD database. In...
Abstract Objective Patients with autoimmune diseases were advised to shield avoid coronavirus disease 2019 (COVID-19), but information on their prognosis is lacking. We characterized 30-day outcomes and mortality after hospitalization COVID-19 among patients prevalent diseases, compared hospital admissions similar seasonal influenza. Methods A multinational network cohort study was conducted using electronic health records data from Columbia University Irving Medical Center [USA, Optum...
OBJECTIVES To characterize the demographics, comorbidities, symptoms, in-hospital treatments, and health outcomes among children adolescents diagnosed or hospitalized with coronavirus disease 2019 (COVID-19) to compare them in secondary analyses patients previous seasonal influenza 2017–2018. METHODS International network cohort using real-world data from European primary care records (France, Germany, Spain), South Korean claims US claims, hospital databases. We included and/or COVID-19 at...
Routinely collected real world data (RWD) have great utility in aiding the novel coronavirus disease (COVID-19) pandemic response. Here we present international Observational Health Data Sciences and Informatics (OHDSI) Characterizing Associated Risks Your Baseline Disease In SARS-COV-2 (CHARYBDIS) framework for standardisation analysis of COVID-19 RWD.
ABSTRACT Objectives To characterize the demographics, comorbidities, symptoms, in-hospital treatments, and health outcomes among children/adolescents diagnosed or hospitalized with COVID-19. Secondly, to describe amongst previous seasonal influenza. Design International network cohort. Setting Real-world data from European primary care records (France/Germany/Spain), South Korean claims US hospital databases. Participants Diagnosed and/or COVID-19 at age <18 between January June 2020;...
Breast cancer is the most frequently diagnosed in females globally. However, we know relatively little about trends males. This study describes United Kingdom (UK) secular breast from 2000 to 2021 for both sexes. We describe a population-based cohort using UK primary care Clinical Practice Research Datalink (CPRD) GOLD and Aurum databases. There were 5,848,436 eligible 5,539,681 males aged 18+ years, with ≥ one year of prior data availability period. estimated crude incidence rates (IR),...
Menopausal Hormone Therapy (MHT) use in Australia fell by 55% from 2001 to 2005, following the release of large-scale findings on its risks and benefits. Comprehensive national data, including information overall prevalence MHT as well duration have not been reported since 2004–5 National Health Survey, when 11% women aged 45+ years were estimated be current users. No data are available “bioidentical” hormone therapy (BHT). The objective this study was determine recent BHT use. A...
BackgroundMedication adherence is crucial for improving clinical outcomes in the treatment of patients. We evaluate effect short message service (SMS) reminder on medication and serum hormones patients with breast cancer aromatase inhibitors.MethodsAn open-label, multi-centre, prospective randomised controlled trial SMS versus Standard Care was conducted. Medication assessed via self-report using Simplified Adherence Questionnaire at baseline, 6 month, 1 year. Androstenedione, estradiol,...
Electronic Health Record (EHR) systems are digital platforms in clinical practice used to collect patients' information related their health status and represents a useful storage of real-world data. EHRs have potential role research studies, particular, platform trials. Platform trials innovative trial designs including multiple arms (conducted simultaneously and/or sequentially) on different treatments under single master protocol. However, the use comes with important challenges such as...
Background In patients with uncontrolled asthma treated medium dose (md) inhaled corticosteroid/long-acting beta2 agonist (ICS/LABA), The Global Initiative for Asthma (GINA) recommends to increase high (hd) ICS/LABA or start therapy consisting of md ICS/LABA+LAMA (long-acting muscarinic antagonist). Adding LAMA on top hd is not recommended Step 4 patients, yet it used in the real world. Patient characteristics influencing treatment step-up are unknown. Objectives Identify determinants option...
Background: The management of colorectal cancer (CRC) is evolving, with advances in screening and treatment. Objective: To leverage population-based data to generate up-to-date UK estimates age sex-specific incidence overall survival for the period 2000-2021. Design: We analysed nationally representative primary care records from Clinical Practice Research Datalink (CPRD) GOLD replicated CPRD Aurum. calculated rates, short- long-term stratified by age, sex, diagnosis year. Results: Overall...
Background: Pancreatic cancer is the seventh leading cause of related mortality worldwide and fifth in United Kingdom (UK), with incidence rates nearly matching mortality. Methods: We conducted a population-based cohort study using Clinical Practice Research Datalink (CPRD) GOLD Aurum databases including patients aged 18+ at least one year prior data, diagnosed between 2000 2021. estimated incidence, period prevalence, survival one, five, ten years, stratified by age, sex, calendar year....
Lung cancer is the leading cause of cancer-associated mortality worldwide. In United Kingdom (UK), there has been a major reduction in smoking, risk factor for lung cancer. Therefore, an up-to-date assessment trends required UK. This study aims to describe burden and terms incidence, prevalence, survival from 2000-2021, using two UK primary care databases.
Abstract Evidence on the comparative effectiveness of osteoporosis treatments is heterogeneous. This may be attributed to different populations and clinical practice, but also differing methodologies ensuring comparability treatment groups before effect estimation amount residual confounding by indication. study assessed denosumab vs oral bisphosphonate (OBP) using propensity score (PS) methods negative control outcome (NCO) analysis. A total 280 288 women aged ≥50 yr initiating or OBP in...
We studied the characteristics of patients prescribed osteoporosis medication and patterns use in European databases. Patients were mostly female, older, had hypertension. There was suboptimal persistence particularly for oral medications. Our findings would be useful to healthcare providers focus their resources on improving specific treatments.To characterise therapy describe drug utilization patterns.We investigated treatment bisphosphonates, denosumab, teriparatide, selective estrogen...
Medication adherence refers to whether a patient takes medication according the frequency prescribed, or continues take prescribed medication. Inadequate may cause alterations in risk-benefit ratios, resulting reduced benefits, increased risks both, and is significantly associated with adverse clinical outcomes higher healthcare costs. We aim examine effect of computer generated short message service (SMS) reminder improving adherence, inhibiting aromatisation process amongst breast cancer...
Using real-world data and past vaccination data, we conducted a large-scale experiment to quantify bias, precision timeliness of different study designs estimate historical background (expected) compared post-vaccination (observed) rates safety events for several vaccines. We used negative (not causally related) positive control outcomes. The latter were synthetically generated true signals with incident rate ratios ranging from 1.5 4. Observed vs. expected analysis using within-database is...
ABSTRACT Objectives The COVID-19 pandemic profoundly affected healthcare systems and patients. There is a pressing need to comprehend the collateral effects of on noncommunicable diseases. Here we examined impact shortterm cancer survival in United Kingdom (UK). We hypothesised that short-term from nine cancers would be reduced during pandemic, particularly benefit screening early detection (e.g., breast colorectal cancer). Design Population-based cohort study. Setting Electronic health...
To derive outcome-based critical result thresholds in the adult patient population.We extracted deidentified laboratory results and outcomes (death or discharged) of patients 18 years older from Medical Information Mart for Intensive Care database. The lower upper were obtained nearest minimum maximum values, which corresponded to predicted probability death at 90%.The value sodium (<123, >153 mmol/L), potassium (<2.2, >6.6 bicarbonate (<15, >49 chloride (<82, >121 urea (>20 creatinine...
Abstract Background: We described the demographics, cancer subtypes, comorbidities, and outcomes of patients with a history coronavirus disease 2019 (COVID-19). Second, we compared hospitalized COVID-19 to diagnosed influenza. Methods: conducted cohort study using eight routinely collected health care databases from Spain United States, standardized Observational Medical Outcome Partnership common data model. Three cohorts were included: (i) COVID-19, (ii) (iii) influenza in 2017 2018....
Abstract Importance Drug shortages leave affected patients in a vulnerable position. Objective To describe incidence and prevalence of use for medicines with suggested at least one European country, as announced by the Medicines Agency, to characterise users these drugs including indication use, duration dosage. Design We performed descriptive cohort study from 2010 up 2024 network databases which have mapped their data Observational Medical Outcomes Partnership (OMOP) Common Data Model...