A5026630803- Bacterial biofilms and quorum sensing
- Antibiotic Resistance in Bacteria
- Vibrio bacteria research studies
- Electronic Health Records Systems
- Chronic Disease Management Strategies
- Cystic Fibrosis Research Advances
- Medical Coding and Health Information
- Bacterial Genetics and Biotechnology
- Pharmaceutical Economics and Policy
- Ginger and Zingiberaceae research
- Microbial Community Ecology and Physiology
- Essential Oils and Antimicrobial Activity
- Antimicrobial Peptides and Activities
- Evolution and Genetic Dynamics
- Genomics and Phylogenetic Studies
- Evolutionary Game Theory and Cooperation
- Health Systems, Economic Evaluations, Quality of Life
- Healthcare Systems and Reforms
AZ Groeninge
2024
Onze Lieve Vrouwziekenhuis Hospital
2024
Ghent University
2019-2024
AZ Maria Middelares
2024
Acinetobacter baumannii is an opportunistic pathogenic bacterium prioritized by WHO and CDC because of its increasing antibiotic resistance. Heterogeneity among strains represents the hallmark A. bacteria. We wondered to what extent extensively used strains, so-called reference reflect dynamic nature intrinsic heterogeneity these analyzed multiple phenotypic traits 43 nonredundant, modern, multidrug-resistant, drug-resistant, pandrug-resistant clinical isolates broadly baumannii. Comparison...
In the present study we evaluated fitness, antimicrobial susceptibility, metabolic activity, gene expression, in vitro production of virulence factors and vivo experimentally evolved Pseudomonas aeruginosa PAO1. These strains were previously presence tobramycin quorum sensing inhibitor furanone C-30 (C-30) carried mutations mexT fusA1 . Compared to wild-type (WT), show a different growth rate suggesting they have an altered fitness. mutants less susceptible than WT strains; also reduced...
The use of quorum-sensing inhibitors (QSI) has been proposed as an alternative strategy to combat antibiotic resistance. QSI reduce the virulence a pathogen without killing it and is claimed that resistance such compounds less likely develop, although there lack experimental data supporting this hypothesis.
Combining antibiotics with potentiators that increase their activity is a promising strategy to tackle infections caused by antibiotic-resistant bacteria. As do not interfere essential processes, it has been hypothesized they are less likely induce resistance. However, evidence supporting this hypothesis lacking. In the present study, we investigated whether Burkholderia cenocepacia J2315 biofilms develop reduced susceptibility toward one such adjuvant, baicalin hydrate (BH). Biofilms were...
The failure of antibiotic therapy in respiratory tract infections cystic fibrosis is partly due to the high tolerance observed Pseudomonas aeruginosa biofilms. This mediated by changes bacterial metabolism linked growth biofilms, opening up potential avenues for novel treatment approaches based on modulating metabolism. goal present study was identify carbon sources that increase inhibiting and/or eradicating activity tobramycin, ciprofloxacin, and ceftazidime against P. PAO1 biofilms grown...
Phytochemicals are promising antibacterials for the development of novel antibiofilm drugs, but their activity in physiologically relevant model systems is poorly characterized. As host microenvironment can interfere with phytochemicals, mimicking complex environment found biofilm associated infections essential to predict clinical potential phytochemical-based antimicrobials. In present study, we examined borneol, citral, and combinations both as well Pickering emulsions against...
Abstract Importance Drug shortages leave affected patients in a vulnerable position. Objective To describe incidence and prevalence of use for medicines with suggested at least one European country, as announced by the Medicines Agency, to characterise users these drugs including indication use, duration dosage. Design We performed descriptive cohort study from 2010 up 2024 network databases which have mapped their data Observational Medical Outcomes Partnership (OMOP) Common Data Model...
Burkholderia cenocepacia infections are difficult to treat and there is an urgent need for alternative (combination) treatments. The use of anti-virulence therapies in combination with antibiotics a possible strategy increase the antimicrobial susceptibility pathogen slow down development resistance. In present study we evaluated β-lactam colistin-potentiating activity, effect non-mevalonate pathway inhibitor FR900098 against B. various vitro vivo models. addition, whether repeated exposure...
Abstract We assembled the whole genome sequence (WGS) of a collection 43 non-redundant modern clinical isolates and four broadly used reference strains Acinetobacter baumannii . Comparison these their WGS confirmed high heterogeneity in capsule loci, types, presence virulence antibiotic resistance genes. However, significant portion strongly differ when compared to several light colony morphology, cellular density, production, natural transformability vivo virulence. These genetic phenotypic...
<sec> <title>BACKGROUND</title> Data quality is fundamental to maintain the trust and reliability of health data for both primary secondary purposes. However, before use data, it essential assess at source develop systematic methods assessment important dimensions. </sec> <title>OBJECTIVE</title> This case study aims offer a dual aim: height weight measurements across seven Belgian hospitals outline obstacles these face in sharing improving standards <title>METHODS</title> Focusing on...
Data quality is fundamental to maintaining the trust and reliability of health data for both primary secondary purposes. However, before use data, it essential assess at source develop systematic methods assessment important dimensions.