A5005848540- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Global Cancer Incidence and Screening
- Lung Cancer Treatments and Mutations
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Medical Imaging and Pathology Studies
- Tracheal and airway disorders
- COVID-19 and healthcare impacts
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Head and Neck Cancer Studies
- Lung Cancer Research Studies
- Venous Thromboembolism Diagnosis and Management
- Disaster Response and Management
- Smoking Behavior and Cessation
- Medical Imaging Techniques and Applications
- Esophageal Cancer Research and Treatment
- Posttraumatic Stress Disorder Research
- BRCA gene mutations in cancer
- Vascular Anomalies and Treatments
- Ureteral procedures and complications
- Acute Ischemic Stroke Management
- Innovations in Medical Education
- Cardiac Valve Diseases and Treatments
- Cardiovascular Health and Risk Factors
- Statistical Methods in Clinical Trials
University College London
2021-2025
University College London Hospitals NHS Foundation Trust
2021-2025
South Tyneside and Sunderland NHS Foundation Trust
2021
Basildon and Thurrock University Hospitals NHS Foundation Trust
2019-2020
Hôpital Européen
2019
Inserm
2019
Hôpital Européen Georges-Pompidou
2019
Papworth Hospital NHS Foundation Trust
2018
Norfolk and Norwich University Hospital
2017
Ipswich Hospital
2013
Introduction Lung cancer screening (LCS) enables the delivery of smoking cessation interventions to a population experiencing long-term tobacco dependence, but optimal method remains unclear. Here, we report uptake and short-term outcomes an ‘opt-out’ referral strategy in LCS cohort. Methods Individuals currently who attended face-to-face lung health check SUMMIT study ( NCT03934866 ) were offered very brief advice on where possible, their local stop service (SSS). Aggregate data obtained...
Lung cancer screening (LCS) reduces lung cancer-related mortality; however, uptake remains low compared with other programmes. In this observational study, we report the impact of timed appointments and reminders on participation in our regional LCS programme. Initial was 53.0% (n=17 274/32 593), higher than previously reported UK, while initial open invitations 29.8% (n=10 246/34 371). Among non-responders, 17.5% (n=4263/24 400) completed triage following a reminder. The increased only...
Breast cancer is the most frequently diagnosed in females globally. However, we know relatively little about trends males. This study describes United Kingdom (UK) secular breast from 2000 to 2021 for both sexes. We describe a population-based cohort using UK primary care Clinical Practice Research Datalink (CPRD) GOLD and Aurum databases. There were 5,848,436 eligible 5,539,681 males aged 18+ years, with ≥ one year of prior data availability period. estimated crude incidence rates (IR),...
<title>Extract</title> COPD causes significant morbidity and mortality – it is the fourth leading cause of death worldwide(1) there urgent need to develop test new therapeutics. Barriers recruitment into clinical trials include complex equipment technical specifications for spirometry imaging, 'clinical stability' in a target population with high risk exacerbations separation trial expertise from usual patient care(2). Strategies improve are therefore required.
Abstract Introduction Integrating effective smoking cessation strategies for individuals undergoing lung cancer screening stands to significantly increase the impact of programmes. We assessed low-dose computed tomography (LDCT) findings on among high-risk adults who currently smoked. Aims and Methods 13 035 individuals, aged 55–77 years, attended a health check appointment, as part prospective observational cohort study (the SUMMIT Study), prior baseline LDCT scan. Logistic regressions...
Abstract Introduction There is limited evidence for the malignancy risk posed by new nodules appearing at annual screening rounds or short-term interval nodule follow-up (NFU) CTs in lung cancer programmes. We investigated incidence rate and NFU first CT a cohort participant characteristics which predicted malignancy. Methods 11,566 participants underwent baseline between April 2019 2020. were read conjunction with computer-aided detection software semi-automated volumetry. Nodule management...
Prospective validation and comparison of the performance nodule management protocols is limited. The aim this study was to examine size risk thresholds for assessing malignancy in solid nodules at baseline low-dose CT (LDCT) a lung cancer screening (LCS) programme. This an observational using data from SUMMIT Study, prospective longitudinal investigating LDCT LCS. Participants were 55-77 years old met either United States Preventative Services Task Force (2013) criteria or had PLCOm2012...
Pulmonary nodules are commonly found in Lung Cancer Screening (LCS), with results typically communicated by face-to-face or telephone consultation. Providing LCS on a population basis requires resource efficient and scalabe communication methods. Written provides one such method. Here, we assess participant satisfaction this approach setting investigate characteristics associated dissatisfaction.
The optimal management of small but growing nodules remains unclear. SUMMIT study nodule algorithm uses a specific threshold volume 200 mm 3 before referral solid to the multidisciplinary team for further investigation is advised, with below this kept under observation within screening programme. Malignancy risk size >200 at initial 3-month interval scan was 58.3% per-nodule level, compared 13.3% in ≤200 (relative 4.4, 95% CI 2.17 8.83). positive predictive value combination growth...
<ns4:p>Acute pulmonary embolism (PE) is a disease frequently encountered in clinical practice. While the management of haemodynamically stable, low risk patients with acute PE well established, managing intermediate often presents therapeutic dilemma. In this review, we discuss various options available patient group. This includes thrombolysis, surgical embolectomy and catheter directed techniques. We have also explored role specialist response teams such patients. </ns4:p>
<h3>Introduction</h3> Clinical trial recruitment in COPD is challenging for multiple reasons, including mismatch between location of care and clinical expertise. Lung Cancer Screening (LCS) offers a way reaching more patients who are already showing willingness to engage with healthcare. We report the response rate characteristics individuals self-reported invited an interventional through LCS. <h3>Methods</h3> The SUMMIT LCS study (NCT03934866) used screening questionnaire determine lung...