A5113638942- Polyomavirus and related diseases
- Liver Disease Diagnosis and Treatment
- Parvovirus B19 Infection Studies
- Liver Disease and Transplantation
- Full-Duplex Wireless Communications
- Antenna Design and Analysis
- Alcohol Consumption and Health Effects
- Magnesium in Health and Disease
- Nutrition and Health in Aging
- Diet and metabolism studies
- Calcium signaling and nucleotide metabolism
- Diet, Metabolism, and Disease
- RNA Interference and Gene Delivery
- Herpesvirus Infections and Treatments
- Pancreatic function and diabetes
- Trace Elements in Health
- Lysosomal Storage Disorders Research
- Parathyroid Disorders and Treatments
- Microbial Inactivation Methods
- Celiac Disease Research and Management
- Inflammatory Bowel Disease
- Energy Harvesting in Wireless Networks
- Chronic Lymphocytic Leukemia Research
- Lipid metabolism and biosynthesis
- Cytomegalovirus and herpesvirus research
Sapienza University of Rome
2011-2025
American College of Gastroenterology
2020
University of Foggia
2015
University of Siena
2011
Temple University
2010
In hepatology, there is growing interest in identifying the mechanisms and risk factors underlying liver diseases with increasing incidence, particular focus on metabolic dysfunction-associated steatotic disease (MASLD) its complications. Simple sugars have been recognized as key contributors to injury progression, not only context of MASLD but also beyond. As a result, numerous studies aimed elucidate their role pathophysiology. Specifically, simple associated pivotal involved onset...
Abstract Genomic variability in the viral protein 1 region of BK polyomavirus (BKV) may change ability virus to replicate. The significance such changes was studied clinical samples taken from kidney transplant patients with and without BKV nephropathy. A 94 base‐pair fragment amplified 68 urine, 28 blood, 12 renal biopsy eight nephropathy, 100 urine samples, 17 blood three 41 218 controls. DNA sequenced amino acid were predicted by Expert Protein Analysis System program (ExPASy, Swiss...
Nowadays, better immunosuppressors have decreased the rates of acute rejection in kidney transplantation, but also led to emergence BKV-associated nephropathy (BKVAN). Therefore, we prospectively investigated BKV load plasma and urine samples a cohort transplants, receiving basiliximab combined with mycophenolate mofetil-based triple immunotherapy, evaluate difference between replication during first 3 months post-transplantation, characterized by non-depleting action basiliximab, versus...
Abstract Prostate cancer represents the second leading cause of deaths in Western countries. Viral infections could play a role prostate carcinogenesis. Human polyomavirus BK (BKV) is possible candidate because its transforming properties. In this study, BKV sequences urine, blood, fresh, and paraffin‐embedded samples from 26 patients were searched using Q‐PCR analysis. T antigen (TAg) p53 localization neoplastic cells evaluated by immunohistochemical Also, presence mutations 5–9 exons gene...
OBJECTIVES: To investigate whether blood total lysosomal acid lipase activity (BT-LAL) levels are uniquely associated with the noncirrhotic and cirrhotic stages of nonalcoholic fatty liver disease (NAFLD) protection from NAFLD in metabolically/genetically predisposed subjects a normal liver. clarify which enzyme-carrying circulating cells involved reduced BT-LAL NAFLD. METHODS: In cross-sectional study, was measured by fluorigenic method patients (n = 118), alcoholic 116), hepatitis C...
Alicyclobacillus acidoterrestris is the main cause of most spoilage problems in fruit juices and acidic products. Since soil borne species often contaminate do not need strict extreme requirements for survival, it a great concern to investigate whether how could evolve from their ecological niches microbial community new environments as juices. In this study, 23 isolates thermo-acidophilic, spore-forming bacteria were characterized by cultural molecular methods. addition, 2 strains isolated...
Alcoholic cirrhosis represents 1% of all cause-of-deaths worldwide. Its incidence is higher in males and results from the combination environmental genetic factors. Among determinants alcoholic cirrhosis, patatin-like phospholipase domain protein 3 (PNPLA3) rs738409 most widely validated determinant. Recent cross-sectional studies on alcohol abusers identified transmembrane-6 superfamily member 2 (TM6SF2) rs58542926, membrane bound O-acyltransferase containing 7 (MBOAT7) rs641738, cluster...
Abstract Hemorrhagic cystitis is characterized by hematuria due to inflammation of the bladder. In bone marrow transplants, this disease linked infection human polyomavirus BK, whereas role JC unclear. The transcriptional control regions both viruses contain important cellular transcription factor binding sites that undergo rearrangement process generating suitable variants could be more active for viral replication and onset hemorrhagic cystitis. study urine obtained from seven patients...
In nonalcoholic steatohepatitis animal models, an increased lipid droplet size in hepatocytes is associated with fibrogenesis. Hepatocytes large (Ld-MaS) or small (Sd-MaS) macrovesicular steatosis may coexist the human liver, but factors predominance of one type over other, including hepatic fibrogenic capacity, are unknown. pre-ischemic liver biopsies from 225 consecutive transplant donors, we retrospectively counted Ld-MaS and Sd-MaS defined predominant as involving ≥50% steatotic...
(1) Background: We investigated, for the first time, whether dietary simple sugar intake affects MELD score changes over time in a cohort of cirrhotic liver transplant candidates. (2) Methods: score, habits using 3-day food diary, and visceral adipose tissue index (VATI) measured with CT scan were assessed 80 consecutive outpatient patients at baseline, after counseling to follow current nutritional guidelines. The was reassessed six months DELTA-MELD calculated as second assessment minus...
We aimed to evaluate the magnesium content in human cirrhotic liver and its correlation with serum AST levels, expression of hepatocellular injury, MELDNa prognostic score. In biopsies obtained at transplantation, we measured tissue 27 patients (CIRs) 16 deceased donors healthy (CTRLs) by atomic absorption spectrometry within hepatocytes 15 CIRs using synchrotron-based X-ray fluorescence microscopy. 31 10 CTRLs, evaluated immunohistochemical transient receptor potential melastatin 7 (TRPM7),...
Abstract This study aimed to ascertain, for the first time, whether serum magnesium (Mg) concentration is affected by presence of hepatocellular carcinoma (HCC). We retrospectively enrolled consecutive cirrhotic patients with a diagnosis HCC (n = 130) or without subsequent evidence during surveillance 161). Serum levels Mg were significantly (P < 0.001) lower in than those (median [interquartile range]: 1.80 [1.62–1.90] mg/dl vs. 1.90 [1.72–2.08] mg/dl). On multivariate logistic...
Chronic inflammatory rheumatic diseases (CIRDs) are immune-mediated pathologies involving joints. To date, TNFα-blocking agents administration is the most promising therapy, although these treatments associated with an increased Polyomavirus JC (JCPyV) reactivation, etiological agent of Progressive Multifocal Leukoencephalopathy (PML). The aim this study was recruitment and analysis a CIRDs cohort in order to investigate possible correlation between JCPyV presence influence anti-TNF-α on...