A5068585829- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Hepatitis C virus research
- Organ Transplantation Techniques and Outcomes
- Hepatitis B Virus Studies
- Alcohol Consumption and Health Effects
- Cancer Immunotherapy and Biomarkers
- Diet, Metabolism, and Disease
- Hepatitis Viruses Studies and Epidemiology
- Colorectal Cancer Treatments and Studies
- Liver Diseases and Immunity
- Drug-Induced Hepatotoxicity and Protection
- Diet and metabolism studies
- Cholesterol and Lipid Metabolism
- Systemic Lupus Erythematosus Research
- Endoplasmic Reticulum Stress and Disease
- Lipid metabolism and biosynthesis
- Lipid metabolism and disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Diabetes and associated disorders
- Glycosylation and Glycoproteins Research
- Viral gastroenteritis research and epidemiology
- Renal Transplantation Outcomes and Treatments
- Pancreatic and Hepatic Oncology Research
- Transplantation: Methods and Outcomes
Université Paris Cité
2017-2025
Hôpital Cochin
2018-2025
Inserm
2017-2025
Assistance Publique – Hôpitaux de Paris
2017-2025
Institut Cochin
2019-2025
Centre National de la Recherche Scientifique
2023-2025
Sorbonne Paris Cité
2017-2024
Demos
2023
Groupe Hospitalier Cochin - Port-Royal, Hôtel-Dieu, Broca - La Collégiale
2021-2023
Institut Pasteur
2017-2021
ABSTRACT Background Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory disease, associated with MEFV mutations. FMF patients can experience liver involvement, potentially leading to cirrhosis. Objectives This study aimed evaluate involvement in at a French tertiary centre for adult FMF. Methods We conducted an observational displaying 2 pathogenic mutations National Reference Center Autoinflammatory Diseases and Inflammatory Amyloidosis (CEREMAIA) Paris included...
Despite its documented prognostic relevance, hepatic encephalopathy (HE) is not considered in liver transplantation (LT) due to possible poor objectivity. To override this problem, we aimed analyze if an objective diagnosis of HE may confer additional mortality risk beyond MELD. Study and validation cohorts patients with cirrhosis were Italy Canada, respectively. Patients be HE+ episode overt was a hospitalization. Of the 486 enrolled Italy, 184 (38%) HE+. During 6‐month follow‐up, 77 died...
The diagnosis of liver fibrosis is critical in managing chronic diseases. EASL guidelines now recognize ultrasound elastography as a valuable, non-invasive method for assessing fibrosis. However, there lack uniform use and reporting the technique. purpose this position paper was to provide guidance on using techniques interpreting results clinical practice. A French national consensus panel experts radiology hepatology, convened by SIAD (Société d'Imagerie Abdominale et Digestive) AFEF...
the side effects of immune checkpoint inhibitors (ICI) pose a problem for clinical management cancer patients. There is lack knowledge value liver biopsy in patients with ICI-related drug-induced injury (ICI-DILI). The aim this study was to explore impact on and response corticosteroids, according histological findings.We conducted retrospective, single-center evaluate biochemical, data 35 ICI-DILI between 2015 2021 university hospital France.Of (median [interquartile range] age 62 [48-73]...
ABSTRACT Background and Aims Early assessment of hepatocellular carcinoma (HCC) risk could improve long‐term outcomes in people with chronic hepatitis B virus (HBV) infection. Some existing HCC predictive scores are not easily implementable. We developed easy‐to‐use based on behavioural routine bio‐clinical data HBV Methods Eight‐year follow‐up was analysed from infection enrolled the French ANRS CO22 HEPATHER cohort. Patients were randomly split into two samples (training/testing). A...
There is concern about the burden of liver injury in patients with cancer exposed to immune checkpoints inhibitors (ICIs).In a retrospective cohort study, we evaluated likelihood grade 3/4 injury, cholestatic and failure, as per Common Terminology Criteria for Adverse Events (CTCAE) version 5, following treatment ICIs. We compared these occurrences group who were propensity-matched treated conventional chemotherapy. For all ICI experiencing conducted causality assessment using RUCAM method...
Alcoholic cirrhosis represents 1% of all cause-of-deaths worldwide. Its incidence is higher in males and results from the combination environmental genetic factors. Among determinants alcoholic cirrhosis, patatin-like phospholipase domain protein 3 (PNPLA3) rs738409 most widely validated determinant. Recent cross-sectional studies on alcohol abusers identified transmembrane-6 superfamily member 2 (TM6SF2) rs58542926, membrane bound O-acyltransferase containing 7 (MBOAT7) rs641738, cluster...
Background . No data are available on liver transplantation (LT) outcome and donor steatosis, classified as large droplet macrovesicular (Ld-MaS), small-droplet (Sd-MaS), true microvesicular (MiS), taking into account the recipient Hepatitis C virus (HCV) status. Aim We investigate impact of allograft steatosis reclassified according to Brunt classification early graft function survival after LT. Methods retrospectively reviewed 204 consecutive preischemia biopsies grafts transplanted in our...