A5031933114- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Nail Diseases and Treatments
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Plant Pathogens and Fungal Diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- Cytomegalovirus and herpesvirus research
- Yeasts and Rust Fungi Studies
- Liver Disease Diagnosis and Treatment
- Influenza Virus Research Studies
- Chronic Lymphocytic Leukemia Research
- Tourism, Volunteerism, and Development
- Alcohol Consumption and Health Effects
- Toxoplasma gondii Research Studies
- Dermatological and Skeletal Disorders
- Enterobacteriaceae and Cronobacter Research
- Reproductive tract infections research
- Primate Behavior and Ecology
- Neurological Disorders and Treatments
- HIV, Drug Use, Sexual Risk
- Immunodeficiency and Autoimmune Disorders
- Healthcare Systems and Public Health
- Yersinia bacterium, plague, ectoparasites research
- Zoonotic diseases and public health
Université de Montpellier
2009-2023
Inserm
2016-2023
Institut de Recherche pour le Développement
2012-2023
Groupe Hospitalier Cochin - Port-Royal, Hôtel-Dieu, Broca - La Collégiale
2021
Université Paris Cité
2021
Assistance Publique – Hôpitaux de Paris
2021
Bipar
2021
Recherches Translationnelles sur le VIH et les Maladies Infectieuses
2019
Agropolis International
2019
University Hospital St. Ivan Rilski
2018-2019
Minor species of the Candida albicans complex may cause overestimation epidemiology C. albicans, and misidentifications could mask their implication in human pathology. Authors determined occurrence minor (C. africana, dubliniensis stellatoidea) among Yaoundé HIV-infected patients, Cameroon. Stool, vaginal discharge, urine oropharyngeal samples were analysed by mycological diagnosis. Isolates identified conventional methods mass spectrometry (MS; carried out matrix-assisted laser...
Genetic diversity analyses were performed by sero-genotyping and multi-locus sequence typing on 252 cryptococcal isolates from 13 HIV-positive Ivorian patients followed-up for meningitis. Antifungal susceptibility according to the CLSI M27A3 method. The majority (67.8%) of belonged Cryptococcus neoformans (serotype A) species complex, with 93% being VNI 7% VNII. deuterogattii VGII B) represented 16.7% strains, while C. neoformans/C. deneoformans VNIII AD) hybrids accounted 15.1% strains. One...
Cryptococcal meningitis is a severe opportunistic infection in HIV-infected patients. In Ivory Coast, despite the availability of antiretroviral treatment (ART), this still prevalent. The study investigates genetic diversity 363 clinical isolates Cryptococcus from 61 Ivorian HIV-positive patients, occurrence mixed infections and vitro antifungal susceptibility isolates. Serotyping was performed via LAC1 CAP64 gene amplification. Genotyping using phage M13 core (GACA)4 (GTG)5 primers...
Fungi belonging to the Cryptococcus genus and related genera (Filobasidium, Holtermanniella, Naganishia, Papiliotrema, Solicoccozyma, Vishniacozyma) are encapsulated yeasts found in either environment or animal sources. However, precise biotopes of most species remain poorly defined. To assess whether wild birds from southern France can carry spread pathogenic (i.e., C. neoformans gattii complexes), as well lesser-studied (non-neoformans/gattii former spp.), 669 89 received for care over a...
At a time when the rates of HIV, hepatitis C virus (HCV), and B (HBV) infections have risen among injection drug users (IDUs) in other countries region, little is known about prevalence these Bulgarian injectors their sexual risk behaviours. IDUs ( n = 773) community-based needle exchange programme (NEP) two major treatment facilities Sofia completed structured interview were tested for HBV, HCV antibodies. While sample was 73.9%, HBV HIV low −6% 0.5%, respectively. Having more than 10...
Cross-resistance to medical azoles by exposure azole pesticides is well documented for Aspergillus family fungi but poorly evaluated other environmental pathogen fungi, particularly yeasts belonging the Cryptococcus neoformans/Cryptococcus gattii species complexes.One thousand C. neoformans yeast were exposed various concentrations of seven different commonly used pesticides. Clones surviving picked randomly, and their minimal inhibitory (MICs) fluconazole, voriconazole, posaconazole,...
The aim of this study was to assess the biotope Cryptococcus neoformans/Cryptococcus gattii species complex from Ivory Coast, and clarify possible epidemiological relationship between environmental clinical strains.Samples Eucalyptus camaldulensis (n=136), Mangifera indica (n=13) pigeon droppings (n=518) were collected different sites close living environment Ivorian HIV patients with cryptococcosis (n=10, 50 strains). Clinical strains characterized by molecular serotyping genotyping [RFLP...
Neuromeningeal cryptococcosis is a life-threatening infection of the central nervous system, caused by encapsulated yeast belonging to Cryptococcus neoformans and gattii species complexes. Recent data showed that virulence antifungal resistance are variable for yeasts C. complex. There an increase in fluconazole complex according genotype. In present study, (i) we explored compared mechanisms between deuterogattii clinically resistant strains induced fluconazole-resistant exposure vitro,...
Cryptococcal meningitis (CM) may be caused by several species of Cryptococcus.We describe a fatal case CM in HIV-positive patient from Ivory Coast infected Cryptococcus neoformans VNI and Cryptococcusdeuterogattii. Isolates were recovered cerebrospinal fluid (CSF) prior to systemic antifungal treatment. Six isolates studied (the entire culture plus five isolated colonies it). Serotyping was performed via LAC 1 CAP 64 gene amplification. Genotyping using restriction fragment length...
Cryptococcal meningitis is a dreadful opportunistic fungal infection amongst human immunodeficiency virus (HIV)-infected patients. One complication in the management of disease possible patient by two or more different strains Cryptococcus neoformans. This study investigated intra-individual genetic diversity and antifungal susceptibility C. neoformans isolates from Yaoundé (Cameroon) HIV-infected patients with cryptococcal meningitis. Twenty-five clinical were obtained during prospective...
The molecular epidemiology and the antifungal susceptibility profiles of Candida albicans are scarce in Cameroon. Authors studied genetic diversity C. isolates from Yaoundé HIV-infected patients. Clinical were obtained by mycological diagnosis oropharyngeal swabs, stools, urine, vaginal swabs confirmed Light cycler real-time PCR ITS1 region 5.8s ribosomal DNA. ABC genotypes Hwp1 gene amplification carried out with specific primers. Microsatellite length polymorphism HIS3, CDC3, EF3...
Fluconazole (FCZ), either alone or in combination, is often administered for treatment of cryptococcal meningitis, especially sub-Saharan Africa. Its extensive use has led to the emergence FCZ-resistant strains. The mechanisms underlying FCZ resistance are poorly documented yeasts belonging Cryptococcus gattii species complex. literature suggests that could be due mutations and/or overexpression ERG11 gene (encoding 14-α-demethylase) and efflux pumps such as MDR AFR (two subclasses ABC...
Cryptococcus neoformans and gattii species complexes are pathogens causing cryptococcal meningitis, a fungal infection that leads to death unless treated. Worldwide, it is estimated kill over 180,000 individuals annually.We aim investigate the molecular diversity of C. isolates from strains isolated 1995 present day different continents.In this study, we analysed by MLST antifungal susceptibility using broth microdilution method according CLSI M27-A4 protocol total 26 complex both clinical...
This study was conducted in Côte d’Ivoire to determine the respective prevalence of Candida species and their susceptibility profile antifungal agents identify emergence resistance.This retrospective from 2017 2019 at Institute Pasteur on patients with fungal disease. The yeasts isolated identified were subcultured a chromogenic medium MALDI-TOF-MS. Sensitivity tests performed using CLSI method evaluated by M27. In total, 227 spp. 1941 patients. Most samples vaginal swabs (120/228). Using...
Lamivudine (LAM) is not recommended in the treatment of chronic hepatitis B due to high-rate resistance: 49% 70% after 3rd and 5th year.LAM-resistance more frequent cases with high viral load or lack complete HBV-DNA suppression within 6 months.Antiviral effect LAM rapid potent if level low.Subjects who are indicated for prophylactic NUC-therapy prior immunosuppression as well cirrhotics relatively low load, but data on efficacy such patient populations limited.We evaluated 97 patients (56...
The histopathology of hepatitis B is diverse and reflects the natural history chronic HBV-infection.Liver biopsy gold standard for assessment disease-activity fibrosis.Treatment-decision based on liver disease severity as well patient's age, viral load, HBeAg status.The relationship between these parameters not studied in details.We analysed treatment-naïve patients from single canter: 231 with histologically-proven (CHB) 104 subjects clinical, laboratory ultrasound signs cirrhosis...
We present data from a single hepatology centre in Bulgaria which started its activity the late 1990s.Currently 427 patients are treated with nucleotide or nucleoside analogues (NUCs), 104 of whom liver cirrhosis.The majority -60% -are diagnosed chronic hepatitis B infection (both and cirrhosis) after 2000.The females less than 1/3 patients.HBe antigen carriers 86 -26% 9 those cirrhosis -8.5%.The viral was on average at age 45.7±13.9 years for (44.6±13.5 males 48.0±14.7 females).For...
MedInformI S U E 1 , 2 0 9 963 MedInform 13.9 for F3 and F4 stages, respectively).There was a trend an increase of the mean age patients from subgroups with mild to severe activity grades.The LC significantly higher compared that different grades, respectively (p= 0.001).There were significant differences between ages F1, F2 or stages those (p=0.015-0.0001).No sex difference found in comparison individual grades fibrosis. ConclusionAbout 30 percent Bulgarian CHB are cirrhotic before starting...