A5077051180- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Neuroendocrine Tumor Research Advances
- Gallbladder and Bile Duct Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Esophageal and GI Pathology
- Cancer Genomics and Diagnostics
- Gastric Cancer Management and Outcomes
- Renal cell carcinoma treatment
- Gastrointestinal disorders and treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Esophageal Cancer Research and Treatment
- Colorectal Cancer Treatments and Studies
- Lung Cancer Research Studies
- Genetic and Kidney Cyst Diseases
- Neuroblastoma Research and Treatments
- Gastrointestinal Tumor Research and Treatment
- Colorectal Cancer Screening and Detection
- Pediatric Hepatobiliary Diseases and Treatments
- Gastrointestinal Bleeding Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Biliary and Gastrointestinal Fistulas
- Colorectal and Anal Carcinomas
- Cancer Treatment and Pharmacology
- Immunotherapy and Immune Responses
Yale University
2015-2024
University of New Orleans
2022
American College of Surgeons
2007-2020
Fistula Foundation
2020
University of Verona
2020
Yale Cancer Center
2001-2019
Northwestern University
2014-2018
Yale New Haven Hospital
2008-2018
Public Knowledge
2017
American College of Radiology
2017
Modifications of FOLFIRINOX are widely used despite the absence prospective data validating efficacy in metastatic disease (metastatic pancreatic cancer (MPC)) or locally advanced (LAPC). We conducted a multicentre phase II study modified to assess impact dose attenuation MPC and LAPC. Patients with untreated LAPC received (irinotecan bolus 5-fluorouracil reduced by 25%). Adverse events (AEs) were compared full-dose FOLFIRINOX. Response rate (RR), median progression-free survival (PFS)...
Positively charged lipophilic compounds, such as rhodamine 123, localize in mitochondria and are selectively accumulated retained by carcinoma cells. It has been suggested that this phenotype may be exploited for selective killing of cells cations. Here we report doubly positively dequalinium, which used 30 years an antimicrobial agent over-the-counter mouthwashes, lozenges, ointments, paints, exhibits significant anticarcinoma activity. Dequalinium is more effective than seven eight...
To evaluate surgical performance in pancreatoduodenectomy using clinically relevant postoperative pancreatic fistula (CR-POPF) occurrence as a quality indicator.Accurate assessment of surgeon and institutional requires (1) standardized definitions for the outcome interest (2) comprehensive risk-adjustment process to control differences patient risk.This multinational, retrospective study 4301 pancreatoduodenectomies involved 55 surgeons at 15 institutions. Risk CR-POPF was assessed...
Objective: The aim of this study was to identify the optimal fistula mitigation strategy following pancreaticoduodenectomy. Background: utility technical strategies prevent clinically relevant postoperative pancreatic (CR-POPF) pancreatoduodenectomy (PD) may vary by circumstances anastomosis. Fistula Risk Score (FRS) identifies a distinct high-risk cohort (FRS 7 10) that demonstrates substantially worse clinical outcomes. value various in these particular high-stakes cases has not been...
This multicenter study sought to evaluate the accuracy of American College Surgeons National Surgical Quality Improvement Program's (ACS-NSQIP) surgical risk calculator for predicting outcomes after pancreatoduodenectomy (PD) and determine whether incorporating other factors improves its predictive capacity.The ACS-NSQIP has been proposed as a decision-support tool predict complication various operations. Although it considers 21 preoperative factors, does not include procedure-specific...
OBJECTIVES The aim of this study was to assess the utility endoscopic ultrasound (EUS) with fine-needle aspiration (FNA) in patients unexplained common bile duct strictures after retrograde cholangiopancreatography (ERCP) and intraductal tissue sampling. METHODS Records were reviewed for all subjects undergoing EUS evaluation at our institution. 40 had either a final histologic diagnosis (24) or no evidence malignancy least 1 yr follow-up (16). RESULTS finding pancreatic head mass and/or an...
Abstract Background The clinical relevance of molecular biomarkers in oncology management has been recognized breast and lung cancers. We evaluated a blood-based multigene assay for neuroendocrine tumors (NETs) real-world study (U.S. registry NCT02270567). Diagnostic accuracy relationship to disease status two cohorts (treated watch-and-wait) were evaluated. Materials Methods Patients with NETs (n = 100) followed 6–12 months. Patients’ primary gastroenteropancreatic (68%), 20%, unknown...
Asymptomatic pancreatic cysts are a common clinical problem but only minority of these cases progress to cancer. Our aim was compare the accuracy detect malignancy 2015 American Gastroenterological Association (AGA), 2012 International Consensus/Fukuoka (Fukuoka guidelines [FG]), and 2010 College Radiology (ACR) guidelines.We conducted retrospective study at 3 referral centers for all patients who underwent resection an asymptomatic cyst between January 2008 December 2013. We compared in...
<h3>Background</h3> Checkpoint inhibitors (CPI) have revolutionized the treatment of metastatic melanoma, but most patients treated with CPI eventually develop progressive disease. Local therapy including surgery, ablation or stereotactic body radiotherapy (SBRT) may be useful to manage limited progression, criteria for patient selection not been established. Previous work has suggested progression-free survival (PFS) after local is associated patterns immunotherapy failure, this studied in...
Ampullary adenocarcinoma is a rare malignant neoplasm that arises within the duodenal ampullary complex. The role of adjuvant therapy (AT) in treatment has not been clearly defined.To determine if long-term survival after curative-intent resection may be improved by selection patients for AT directed histologic subtype.This multinational, retrospective cohort study was conducted at 12 institutions from April 1, 2000, to July 31, 2017, among 357 with resected, nonmetastatic receiving surgery...
This phase II trial evaluated continuous-infusion cisplatin and fluorouracil (5-FU) with radiotherapy followed by esophagectomy. The objectives of this were to determine the complete pathologic response rate, survival toxicity, pattern failure, feasibility administering adjuvant chemotherapy in patients resectable cancer esophagus treated preoperative chemoradiation.Patients staged using computed tomography, endoscopic ultrasound, laparoscopy. treatment plan consisted continuous intravenous...
The investigation and treatment of 131 patients with 'obscure' gastrointestinal bleeding has been reviewed. One hundred six were assessed electively for recurrent haemorrhage, 25 presented as emergencies. major presenting feature was melaena (55 patients), anaemia (35), rectal (34), haematemesis (six) ileostomy (one). lesions responsible haemorrhage colonic angiodysplasia (52 small bowel vascular anomalies (16), Meckel's diverticula (nine), smooth muscle tumours (seven), gastric (four),...
PURPOSE The purpose of this study was (1) to review systemic therapy practice patterns assess how information regarding nodal status currently influences decisions, and (2) long-term outcome patients who do not undergo axillary dissection compared with do. METHODS AND MATERIALS For the current portion study, records 292 presented in past 3 years invasive breast cancer underwent conservative surgery were reviewed determine administered respect patient age, primary tumor size, clinical status,...
BACKGROUND Endoscopic ultrasound (EUS) has been compared to intraoperative surgical palpation for diagnosis of vascular invasion by pancreatic cancer. This study compares EUS with resection and histologic evidence in resected masses. METHODS All patients solid masses who underwent both preoperative surgery at 1 hospital over a 7 year period were identified. The relationship adjacent vessels was prospectively assessed EUS. findings pathology gold standards. "Vascular adherence" defined as...
Abstract BACKGROUND Measures of vascular endothelial growth factor (VEGF) expression in pancreatic cancer typically have been qualitative or semiquantitative. The objective this study was to use a series algorithms called AQUA that quantitatively assesses protein on tissue microarrays (TMAs) compare situ VEGF and its primary receptors, receptor 1 (FLT‐1) (FLK‐1), TMA. METHODS TMAs were constructed by arraying 1.5‐mm cores from 76 samples adenocarcinoma (1996‐2002) obtained the archives Yale...
Pancreatic cystic lesions (PCLs) may be precancerous. Those likely to harbor high-grade dysplasia (HGD) or pancreatic cancer (PC) are targets for surgical resection. Current algorithms predict advanced neoplasia (HGD/PC) in PCLs lack diagnostic accuracy. In tissue and cyst fluid (CF) from PCLs, we sought identify validate novel methylated DNA markers (MDMs) that discriminate HGD/PC low-grade (LGD) no (ND).From an unbiased whole-methylome discovery approach using predefined selection criteria...
This study aims to present a full spectrum of individual patient presentations pancreatic fistula risk, and define the utility mitigation strategies amongst some most prevalent, vulnerable scenarios surgeons encounter.The FRS has been utilized identify technical associated with reduced CR-POPF incidence across various risk strata. However, risk-stratification using never investigated greater granularity. By deriving all possible combinations elements, individualized assessment could be for...