A5061424018- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Gallbladder and Bile Duct Disorders
- Gastric Cancer Management and Outcomes
- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neuroendocrine Tumor Research Advances
- Nanoparticle-Based Drug Delivery
- Renal cell carcinoma treatment
- Glycosylation and Glycoproteins Research
- Hedgehog Signaling Pathway Studies
- Gastrointestinal disorders and treatments
- Nanoplatforms for cancer theranostics
- Epigenetics and DNA Methylation
- Colorectal Cancer Screening and Detection
- Helicobacter pylori-related gastroenterology studies
- Esophageal and GI Pathology
- Colorectal Cancer Surgical Treatments
- Cancer Cells and Metastasis
- Gastrointestinal Tumor Research and Treatment
- Cancer Research and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Advanced Breast Cancer Therapies
- Cancer Mechanisms and Therapy
University of Tennessee Health Science Center
2015-2024
Baptist Memorial Hospital
2012-2024
Southwest Baptist University
2024
Baptist Memorial Health Care
2023
Eugene O'Neill Theater Center
2023
University of Verona
2018-2020
Fistula Foundation
2020
St. Jude Children's Research Hospital
2019
University of Pennsylvania
2016-2018
Johns Hopkins Medicine
2018
Pancreatic cancer is the fourth leading cause of cancer-related death among men and women in United States. A major challenge treatment remains patients’ advanced disease at diagnosis. The NCCN Guidelines for Adenocarcinoma provides recommendations diagnosis, evaluation, treatment, follow-up patients with pancreatic cancer. Although survival rates remain relatively unchanged, newer modalities including targeted therapies, provide hope improving patient outcomes. Sections manuscript have been...
Ductal adenocarcinoma and its variants account for most pancreatic malignancies. High-quality multiphase imaging can help to preoperatively distinguish between patients eligible resection with curative intent those unresectable disease. Systemic therapy is used in the neoadjuvant or adjuvant cancer setting, as well management of locally advanced metastatic Clinical trials are critical making progress treatment cancer. The NCCN Guidelines Pancreatic Adenocarcinoma focus on diagnosis systemic...
The NCCN Guidelines for Pancreatic Adenocarcinoma discuss the diagnosis and management of adenocarcinomas exocrine pancreas are intended to assist with clinical decision-making. These Insights summarize major discussion points from 2014 Panel meeting. panel focused mainly on borderline resectable locally advanced disease. In particular, discussed definition disease, role neoadjuvant therapy in chemoradiation potential newer, more active chemotherapy regimens both settings.
To test by randomized prospective multicenter trial the hypothesis that pancreaticoduodenectomy (PD) without use of intraperitoneal drainage does not increase frequency or severity complications.Some surgeons have abandoned drains placed during pancreas resection.We 137 patients to PD with (n = 68, drain group) and 69, no-drain compared safety this approach spectrum complications between 2 groups.There were no differences cohorts in demographics, comorbidities, pathology, pancreatic duct...
The NCCN Guidelines for Pancreatic Adenocarcinoma discuss the diagnosis and management of adenocarcinomas exocrine pancreas are intended to assist with clinical decision-making. These Insights important updates 2019 version guidelines, focusing on postoperative adjuvant treatment patients pancreatic cancers.
The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Pancreatic Adenocarcinoma discuss the workup and management of tumors exocrine pancreas. These Insights provide a summary explanation major changes to 2012 Adenocarcinoma. panel made 3 significant updates guidelines: 1) more detail was added regarding multiphase CT techniques diagnosis staging pancreatic cancer, pancreas protocol MRI as an emerging alternative CT; 2) use fluoropyrimidine plus oxaliplatin (e.g.,...
To identify a clinical fistula risk score following distal pancreatectomy.Clinically relevant pancreatic (CR-POPF) pancreatectomy (DP) is dominant contributor to procedural morbidity, yet factors attributable CR-POPF and effective practices reduce its occurrence remain elusive.This multinational, retrospective study of 2026 DPs involved 52 surgeons at 10 institutions (2001-2016). CR-POPFs were defined by 2016 International Study Group criteria, models generated using stepwise logistic...
Prior studies documented that early fixation of femur fractures results in a decreased incidence adult respiratory distress syndrome (ARDS), fat embolism syndrome, and pneumonia. This study evaluates the impact magnitude injury on pulmonary complications length ICU hospital stays 339 trauma patients with fracture undergoing (n = 121) vs. late 218) operative fixation. Groups were similar respect to transfusions, hypotension, associated injuries, but more over age 50 years underwent Patients...
Journal Article SUBACUTE SPONGIFORM ENCEPHALOPATHY—A FORM OF ENCEPHALOPATHY ATTRIBUTABLE TO VASCULAR DYSFUNCTION (SPONGIFORM CEREBRAL ATROPHY) Get access S. NEVIN, NEVIN Maida Vale Hospital for Nervous Diseases and the Brook HospitalLondon Search other works by this author on: Oxford Academic PubMed Google Scholar W. H. MCMENEMEY, MCMENEMEY BEHRMAN, BEHRMAN D. P. JONES Brain, Volume 83, Issue 4, December 1960, Pages 519–564, https://doi.org/10.1093/brain/83.4.519 Published: 01 1960
In the year 2005, an estimated 31,800 people will die of pancreatic cancer in United States. This disease is fourth most common cause cancer-related death among men Its peak incidence occurs seventh and eighth decades life. Although roughly equal two sexes, African Americans appear to have a higher than white Americans. these NCCN Pancreatic Adenocarcinoma guidelines, only tumors exocrine pancreas are discussed; endocrine from islets Langerhans carcinoid not included. For recent version...
NCCN Categories of Evidence and ConsensusCategory 1: The recommendation is based on high-level evidence (e.g., randomized controlled trials) there uniform consensus.Category 2A: lowerlevel 2B: nonuniform consensus (but no major disagreement).Category 3: any level but reflects disagreement.All recommendations are category 2A unless otherwise noted.Clinical trials: believes that the best management for cancer patient in a clinical trial.Participation trials especially encouraged.
To evaluate surgical performance in pancreatoduodenectomy using clinically relevant postoperative pancreatic fistula (CR-POPF) occurrence as a quality indicator.Accurate assessment of surgeon and institutional requires (1) standardized definitions for the outcome interest (2) comprehensive risk-adjustment process to control differences patient risk.This multinational, retrospective study 4301 pancreatoduodenectomies involved 55 surgeons at 15 institutions. Risk CR-POPF was assessed...
Objective: The objective of this study was to test the hypothesis that distal pancreatectomy (DP) without intraperitoneal drainage does not affect frequency grade 2 or higher complications. Background: use routine drains during DP is controversial. Prior study, no prospective trial focusing on has been reported. Methods: Patients undergoing for all causes at 14 high-volume pancreas centers were preoperatively randomized placement a drain drain. Complications and their severity tracked 60...
Objective: The aim of this study was to identify the optimal fistula mitigation strategy following pancreaticoduodenectomy. Background: utility technical strategies prevent clinically relevant postoperative pancreatic (CR-POPF) pancreatoduodenectomy (PD) may vary by circumstances anastomosis. Fistula Risk Score (FRS) identifies a distinct high-risk cohort (FRS 7 10) that demonstrates substantially worse clinical outcomes. value various in these particular high-stakes cases has not been...
Many prostate cancers relapse due to the generation of chemoresistance rendering first-line treatment drugs like paclitaxel (PTX) ineffective. The present study aims determine role miRNAs and Hedgehog (Hh) pathway in chemoresistant cancer evaluate combination therapy using Hh inhibitor cyclopamine (CYA). Studies were conducted on PTX resistant DU145-TXR PC3-TXR cell lines clinical tissues. Drug sensitivity apoptosis assays showed significantly improved cytotoxicity with CYA. To distinguish...
// Sheema Khan 1 , Mara C. Ebeling 2 Mohd S. Zaman Mohammed Sikander Murali M. Yallapu Neeraj Chauhan Ashley Yacoubian 3 Stephen W. Behrman 4 Nadeem Zafar Deepak Kumar 5 Paul A. Thompson 2,6 Meena Jaggi and Subhash Department of Pharmaceutical Sciences Center for Cancer Research, University Tennessee Health Science Center, Memphis, Tennessee, USA Biology Research Sanford Research/USD, Sioux Falls, South Dakota, Pathology, Surgery, Biological Environmental Sciences, the District Columbia,...
This multicenter study sought to evaluate the accuracy of American College Surgeons National Surgical Quality Improvement Program's (ACS-NSQIP) surgical risk calculator for predicting outcomes after pancreatoduodenectomy (PD) and determine whether incorporating other factors improves its predictive capacity.The ACS-NSQIP has been proposed as a decision-support tool predict complication various operations. Although it considers 21 preoperative factors, does not include procedure-specific...