Abstract The use of antiretroviral therapy (ART) has remarkably decreased the morbidity associated with HIV-1 infection, however, prevalence HIV-1-associated neurocognitive disorders (HAND) is still increasing. blood-brain barrier (BBB) major impediment for penetration drugs, causing therapeutics to reach only suboptimal level brain. Conventional drug regimens are not sufficient improve treatment outcomes HAND. In our recent report, we have developed a poloxamer-PLGA nanoformulation loaded...

Endoplasmic reticulum (ER) stress is an intriguing target with significant clinical importance in chemotherapy. Interference ER functions can lead to the accumulation of unfolded proteins, as detected by transmembrane sensors that instigate protein response (UPR). Therefore, controlling induced UPR via natural compounds could be a novel therapeutic strategy for management prostate cancer. Tannic acid (a naturally occurring polyphenol) was used examine mediated pathway cancer cells. treatment...

Abstract Prostate cancer (PCa) cells exploit the aberrant lipid signaling and metabolism as their survival advantage. Also, intracellular storage lipids act fuel for PCa proliferation. However, few studies were available that addressed topic of targeting in PCa. Here, we assessed tannic acid (TA) lipid-targeting ability its capability to induce endoplasmic reticulum (ER) stress by reactive oxygen species (ROS) cells. TA exhibited dual effects inhibiting lipogenic suppression metabolic...

The goal of this investigation was to develop and demonstrate a polymer/paclitaxel self-assembly (PTX-SA) formulation. Polymer/PTX-SAs were screened based on smaller size formulation using dynamic light scattering analysis. Additionally, fluorescence microscopy flow cytometry studies exhibited that polyvinylpyrrolidone (PVP)-based PTX-SAs (PVP/PTX-SAs) had superior cellular internalization capability in MCF7 MDA-MB-231 breast cancer cells. optimized PVP/PTX-SAs less toxicity human red blood...

The therapeutic application of microRNA(s) in the field cancer has generated significant attention research. Previous studies have shown that miR-205 negatively regulates prostate cell proliferation, metastasis, and drug resistance. However, delivery is an unmet clinical need. Thus, development a viable nanoparticle platform to deliver highly sought. A novel magnetic (MNP)-based nanoplatform composed iron oxide core with poly(ethyleneimine)-poly(ethylene glycol) layer(s) was developed. An...

Pancreatic cancer (PanCa) is a lethal disease. Conventional chemotherapies for PanCa offer severe systemic toxicities. Thus, the development of successful nanomedicine-based therapeutic regimen with augmented efficacy highly sought. Naturally occurring pectin and modified pectin-based drug delivery systems exhibit remarkable self-targeting ability via galactose residues to various cells. Herein, we developed used an innovative approach stable nanocomplexes based on tannic acid (MPT-NCs). The...

This study aims at the development and preliminary evaluation of dexamethasone nanomicelles for treating posterior uveitis. Nanomicelles were formulated using polyoxyl 40 stearate (P40S) polysorbate 80 (P80), which are approved by FDA ocular use.

Cellular senescence is one of the prevailing issues in cancer therapeutics that promotes relapse, chemoresistance, and recurrence. Patients undergoing persistent chemotherapy often develop drug-induced senescence. Docetaxel, an FDA-approved treatment for prostate cancer, known to induce cellular which limits overall survival patients. Strategic therapies counter are unmet clinical need. Towards this effort was made a novel therapeutic strategy targets removes senescent cells from tumors, we...

The management of pancreatic cancer (PanCa) is exceptionally difficult due to poor response available therapeutic modalities. Tubulins play a major role in cell dynamics, thus are important molecular targets for therapy. Among various tubulins, βIII and βIV-tubulin isoforms have been primarily implicated PanCa progression, metastasis chemo-resistance. However, specific inhibitors these that potent anti-cancer activity with low toxicity not readily available. We determined mechanisms efficacy...

Indocyanine green (ICG) is one of the FDA-approved near infra-red fluorescent (NIRF) probes for cancer imaging and image-guided surgery in clinical setting. However, limitations ICG include poor photostability, high concentration toxicity, short circulation time, cell specificity. To overcome these hurdles, we engineered a nanoconstruct composed poly (vinyl pyrrolidone) (PVP)-indocyanine that cloaked self-assembled with tannic acid (termed as indocyanine green-based glow nanoparticles probe,...

Organogels have emerged as an alternative carrier for small and macromolecules via transdermal, oral, rectal ophthalmic routes. Pluronic lecithin organogels (PLO gels) are lecithin-based widely used in compounding pharmacies a vehicle enhancing the transdermal permeability of many therapeutic drugs. However, scientific systematic evidence support how well PLO gels help delivery is scanty. Recently, some clinical studies reported nearly complete lack bioavailability certain topically...

Even with an efficient combination of antiretroviral therapy (ART), which significantly decreases viral load in human immunodeficiency virus type 1 (HIV-1)-positive individuals, the occurrence HIV-1-associated neurocognitive disorders (HAND) still exists. Microglia have been shown to a significant role HIV-1 replication brain and subsequent HAND pathogenesis. However, due limited ability ART drugs cross blood–brain barrier (BBB) after systemic administration, addition efflux transporter...

Monocytes serve as sanctuary sites for HIV-1 from which virus is difficult to be eliminated. Therefore, an effective viral suppression in monocytes critical antiretroviral therapy (ART). This study focuses on a new strategy using nanoformulation optimize the efficacy of ART drugs HIV-infected monocytes.Poly(lactic-co-glycolic acid) (PLGA)-based elvitegravir nanoparticles (PLGA-EVG) were prepared by nano-precipitation technique. The physicochemical properties PLGA-EVG characterized...

Breast cancer is one of the most commonly diagnosed cancers in American women. Triple negative breast among advanced and aggressive forms cancer. Treatment options are limited for such cancers, making chemotherapy a convenient effective treatment. Although these therapies can reduce morbidity mortality, it often followed by systemic side effects or relapse. Nanoparticles (NPs) have been considered drug delivery approaches due to their ability target various disease sites. Herein, we aim...

Lung cancer (LC) is one of the leading causes death in both men and women United States. Tannic acid (TA), a water-soluble polyphenol, exhibits wide range biological activities. TA has received much attention as promising compound biomaterial drug delivery fields. fluid (LF) major barrier for distribution drugs to lungs. Therefore, purpose this study was examine interaction with LF effective anti-cancer molecules via pulmonary delivery. The extent adsorption proteins by revealed fluorescence...

Bone metastasis occurs in the majority of cancer patients, which hampers quality life and significantly decreases survival. Aggressive chemotherapy is a traditional treatment regimen that induces severe systemic toxicities. Therefore, bone-directed therapies are highly warranted. We report novel nanoparticle formulation composed poly(vinylpyrrolidone) tannic acid core nanoparticles (PVT NPs) forms self-assembly with zoledronic (ZA@PVT NPs). The construction ZA@PVT NPs was confirmed by...

Cisplatin is a commonly used chemotherapeutic agent to treat wide array of cancers that frequently associated with toxic injury the kidney due oxidative DNA damage and perturbations in cell cycle progression leading death. In this study, we investigated whether thyroid receptor interacting protein 13 (TRIP13) plays central role protection tubular epithelia following cisplatin treatment by circumventing damage. Following treatment, double-stranded repair pathways were inhibited using...

Abstract Objectives: Paclitaxel (Ptxl) is currently the most common first-line therapeutic option for breast cancer (BrCa). However, adverse side effects and problems associated with chemo-resistance, limits its use in clinical settings. Nanoparticle mediated delivery can improve Ptxl activity at tumor site, considered to be an attractive strategy BrCa therapy. Therefore, we aim generate a novel Ptx medical nanoparticle formulation (PMNPs) using polyphenol as carrier, evaluate efficacy...