Raffaele Dalla Valle
A5069549442- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Gallbladder and Bile Duct Disorders
- Liver Disease and Transplantation
- Organ Donation and Transplantation
- Renal Transplantation Outcomes and Treatments
- Pancreatitis Pathology and Treatment
- Colorectal Cancer Screening and Detection
- Renal and Vascular Pathologies
- Immune Cell Function and Interaction
- Liver physiology and pathology
- Gastrointestinal disorders and treatments
- Immune cells in cancer
- Transplantation: Methods and Outcomes
- Gastric Cancer Management and Outcomes
- Neuroendocrine Tumor Research Advances
- Genetic and Kidney Cyst Diseases
- Renal cell carcinoma treatment
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Biliary and Gastrointestinal Fistulas
- Pediatric Hepatobiliary Diseases and Treatments
University of Parma
2016-2025
Ospedale di Parma
2007-2024
Flinders Medical Centre
2024
Flinders University
2024
Tongji Hospital
2024
Huazhong University of Science and Technology
2024
University of Bologna
2023
Cambridge University Hospitals NHS Foundation Trust
2023
Sidney Kimmel Cancer Center
2022
Hospital Regional Universitario de Málaga
2022
Objective: The REDISCOVER consensus conference aimed at developing and validate guidelines on the perioperative care of patients with borderline resectable (BR-) locally advanced (LA) pancreatic ductal adenocarcinoma (PDAC). Summary Background Data: Coupled improvements in chemotherapy radiation, contemporary approach to surgery supports resection BR-PDAC and, a lesser extent, LA-PDAC. Guidelines outlining selection for these are lacking. Methods: Scottish Intercollegiate Network (SIGN)...
Abstract Background Western multicenter studies on distal pancreatectomy with celiac axis resection (DP-CAR), also known as the Appleby procedure, for locally advanced pancreatic cancer are lacking. We aimed to study overall survival, morbidity, mortality and impact of preoperative hepatic artery embolization (PHAE). Methods Retrospective cohort within European-African Hepato-Pancreato-Biliary-Association, DP-CAR between 1-1-2000 6-1-2016. Primary endpoint was survival. Secondary endpoints...
To compare the outcomes between robotic major hepatectomy (R-MH) and laparoscopic (L-MH).Robotic techniques may overcome limitations of liver resection. However, it is unknown whether R-MH superior to L-MH.This a post hoc analysis multicenter database patients undergoing or L-MH at 59 international centers from 2008 2021. Data on patient demographics, center experience volume, perioperative outcomes, tumor characteristics were collected analyzed. Both 1:1 propensity-score matched (PSM)...
The aim of the study was to compare SURG vs SOR regarding OS and progression-free survival (PFS) in a real-world clinical scenario.The treatment for advanced nonmetastatic HCC belonging Barcelona Clinic Liver Cancer stage C (BCLC C) is still controversial.BCLC patients without extrahepatic spread tumoral invasion main portal trunk were considered. Surgical obtained from HE.RC.O.LE.S. Register, whereas sorafenib ITA.LI.CA register inverse probability weighting (IPW) method adopted balance...
Objective: To compare the outcomes of robotic limited liver resections (RLLR) versus laparoscopic (LLLR) posterosuperior segments. Background: Both and have been used for tumors in However, comparative performance safety both approaches not well examined existing literature. Methods: This is a post hoc analysis multicenter database 5,446 patients who underwent RLLR or LLLR segments (I, IVa, VII VIII) at 60 international centers between 2008 2021. Data on baseline demographics, center...
Background: We aimed to assess the ability of comprehensive complication index (CCI) and Clavien-Dindo (CDC) scale predict excessive length hospital stay (e-LOS) in patients undergoing liver resection for hepatocellular carcinoma. Methods: Patients were identified from an Italian multi-institutional database randomly selected be included either a derivation or validation set. Multivariate logistic regression models ROC curve analysis including CCI CDC as predictors e-LOS fitted compare...
NK-cell number and function have been associated with cancer progression. A detailed analysis of phenotypic functional characteristics NK-cells in HCC is still lacking. regulated by activating inhibitory receptors determined genetic factors engagement cognate ligands on transformed or infected cells. We evaluated characteristic patients undergoing curative treatment relation to clinical outcome. from 70 resection ablative treatment, 18 healthy volunteers 12 cirrhotic HCV-infection (controls)...
Abstract Background This study aimed to assess the best achievable outcomes in laparoscopic liver resection (LLR) after risk adjustment based on surgical technical difficulty using a national registry. Methods LLRs registered Italian Group of Minimally Invasive Liver Surgery registry from November 2014 March 2018 were considered. Benchmarks calculated according Achievable Benchmark Care (ABC™). at each centre divided into three clusters (groups I, II and III) Kawaguchi classification. ABCs...
Previous studies support the role of natural killer (NK) cells in controlling hepatocellular carcinoma (HCC) progression. However, ambiguity remains about multiplicity and different NK cell subsets, as a pro-oncogenic function has been suggested. We performed phenotypic functional characterization infiltrating HCC, with corresponding nontumorous tissue liver from patients undergoing resection for colorectal metastasis used controls. identified reduced number tumors higher frequency...
Clear indications on how to select retreatments for recurrent hepatocellular carcinoma (HCC) are still lacking.To create a machine learning predictive model of survival after HCC recurrence allocate patients their best potential treatment.Real-life data were obtained from an Italian registry between January 2008 and December 2019 median (IQR) follow-up 27 (12-51) months. External validation was made derived by another cohort Japanese cohort. Patients who experienced first surgical approach...
Chylous leakage (CL) is a rare complication of laparoscopic live donor nephrectomy (LLDN). It may lead to malnutrition and immunological deficits because protein lymphocyte depletion.Data from 208 consecutive LLDN performed at two institutions, between April 2000 September 2010, were reviewed identify the anatomical basis behind CL along with its diagnostic therapeutic options.CL developed in eight donors (3.8%), as determined by high-volume drainage (range 540-800 mL/24 hr)...
This international multicenter cohort study included 30 centers. Patients with duodenal adenocarcinoma (DAC), intestinal-type (AmpIT) and pancreatobiliary-type (AmpPB) ampullary adenocarcinoma, distal cholangiocarcinoma (dCCA), pancreatic ductal (PDAC) were included. The primary outcome was 30-day or in-hospital mortality, secondary outcomes major morbidity (Clavien-Dindo 3b≥), clinically relevant post-operative fistula (CR-POPF), length of hospital stay (LOS). Results: Overall, 3622...
Abstract Background Nodal assessment in gallbladder cancer remains challenging, particularly incidental cancer. This understages the number of patients with node-positive disease, resulting prognostic inaccuracy and insufficient adjuvant treatment. study aimed to identify risk factors for positive nodes compare discrimination available nodal staging parameters. Methods international cohort assessed resections undertaken between 1 January 2010 31 December 2020. Logistic regression was used...
Artificial intelligence (AI) is becoming more useful as a decision-making and outcomes predictor tool. We have developed AI models to predict surgical complexity the postoperative course in laparoscopic liver surgery for segments 7 8.