A5055923136- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Renal Transplantation Outcomes and Treatments
- Transplantation: Methods and Outcomes
- Organ Donation and Transplantation
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Vascular Procedures and Complications
- Central Venous Catheters and Hemodialysis
- Metabolism and Genetic Disorders
- Clinical Nutrition and Gastroenterology
- Hepatitis C virus research
- T-cell and B-cell Immunology
- Hematopoietic Stem Cell Transplantation
- Cytomegalovirus and herpesvirus research
- Immunotherapy and Immune Responses
- Fatigue and fracture mechanics
- Health Literacy and Information Accessibility
- Hydrogen embrittlement and corrosion behaviors in metals
- Vascular anomalies and interventions
- Congenital Anomalies and Fetal Surgery
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver physiology and pathology
- COVID-19 Clinical Research Studies
- Social Media in Health Education
Addenbrooke's Hospital
2008-2024
Cambridge University Hospitals NHS Foundation Trust
2004-2024
Queen Alexandra Hospital
2010-2023
University of Cambridge
2008-2022
NIHR Cambridge Biomedical Research Centre
2014-2022
Portsmouth Hospitals NHS Trust
2013-2021
Middlesex University
2021
Vidant Medical Center
2017
National Health Service
2008
National Institute for Health Research
2008
Peste des petits ruminants (PPR) is a virus disease of sheep and goats in West Africa. When first described, the was considered variant rinderpest virus. The biological physicochemical characteristics indicate that it closely related to measles, canine distemper viruses. These three viruses form genus Morbillivirus Paramyxoviridae. PPR sufficiently distinct from these 3 justify considering as fourth member genus.
Organoids regenerate human bile ducts Bile carry from the liver and gall bladder to small intestine, where it aids digestion. Cholangiocytes are epithelial cells that line modify as its transported through biliary tree. Chronic diseases involving cholangiocytes account for a large fraction of failure need transplantation. Because donors in short supply, Sampaziotis et al. used organoid technology develop cell-based therapy using tissue (see Perspective by Kurial Willenbring). Cholangiocyte...
Notes1 https://www.weforum.org/agenda/2020/04/pandemics-coronavirus-covid19-economics-finance-stock-market-crisis/2 https://www.sciencedirect.com/science/article/abs/pii/S03772217050035773 https://www.silive.com/coronavirus/2020/03/coronavirus-cuny-suny-suspend-study-abroad-programs-in-5-countries.html4...
Abstract Preventing SARS-CoV-2 infection by modulating viral host receptors, such as angiotensin-converting enzyme 2 (ACE2) 1 , could represent a new chemoprophylactic approach for COVID-19 that complements vaccination 2,3 . However, the mechanisms control expression of ACE2 remain unclear. Here we show farnesoid X receptor (FXR) is direct regulator transcription in several tissues affected COVID-19, including gastrointestinal and respiratory systems. We then use over-the-counter compound...
Hepatocellular carcinoma (HCC) has a poor prognosis with limited therapeutic options. We propose that local immune responses in patients HCC are held check by tumor-infiltrating CD4(+)CD25(+) T-regulatory lymphocytes (T(reg) cells), which suppress the activity and proliferation of effector CD4(+) CD8(+) T cells. The phenotype cell cycle status (TILs) were analyzed via immunohistochemistry sections from undergoing surgery for flow cytometry peripheral blood mononuclear cells TILs isolated...
The purpose of split liver transplantation is to increase the source pediatric grafts without compromising adult donor pool. Early results have been discouraging because technical complications and selection poor risk patients.The a single center experience 41 transplantations were analyzed. Patient graft survival related technique analyzed.Patient for whole group was 90% 88% respectively at median follow up 12 months (range 6-70 months). right lobe 95% left lateral segment 86% 82%...
Renal impairment is common in patients after liver transplantation and attributable large part to the use of calcineurin inhibitor (CNI)-based immunosuppression. We sought determine whether conversion sirolimus-based immunosuppression was associated with improved renal function. In a single-center, randomized, controlled trial, 30 at least 6 months post were randomized remain on CNI-based or switch The primary outcome measure change measured glomerular filtration rate (GFR) between baseline...
Liver transplantation provides a return to satisfactory quality of life (QOL) for the majority patients in short medium term (first 5 years), but there is very little information on QOL longer and factors influencing it. We therefore undertook single-center cross-sectional analysis determine 10 or more years after liver transplantation. All transplant recipients who were followed up at Cambridge Transplant Unit (transplanted between 1968 1994) resident United Kingdom asked complete by post...
Late survival is not improving after liver transplantation. In this study, possible reasons for were investigated.Mortality rates and causes of death ascertained in 4483 adult primary allograft recipients surviving 1 year or more from engraftment, identified through the UK Transplant Database transplanted between 1994 2007. Associations with death, cause retransplantation assessed.Mortality those beyond transplant was than twice that expected general population had improved during study...
Unspecified (nondirected altruistic) kidney donation is becoming increasingly common in the United Kingdom. Questions regarding motivation and characteristics of these donors persist, alongside concerns about regret long-term psychosocial outcomes. The aims this study were to compare physical outcomes unspecified (UKDs) versus specified (SKDs).We performed a cross-sectional study, which detailed assessment was made using validated questionnaires. Additional questions specific also asked,...
Abstract It is essential to minimize the unnecessary discard of procured deceased donor kidneys, but information on rates and extent which can be avoided are limited. Analysis UK Transplant Registry revealed that rate kidneys has increased from 5% in 2002‐3 12% 2011‐12. A national offering system for hard‐to‐place was introduced 2006 (the Declined Kidney Scheme), just 13% were subsequently discarded until 2012 offered through scheme. In order examine appropriateness discard, 20 consecutive...
* Abbreviation: PVT, portal vein thrombosis. Thrombosis of the trunk is not infrequent after liver transplantation (1-3). It has been reported either with full size (0-10%) (4, 5 or reduced grafts (0.8-11%) 1-3), and much more frequent in small children hypoplasia(2-4). When it occurs early, identified as a cause graft failure. Although late thrombosis can be extremely well tolerated, cavernous transformation formation hepatopetal collaterals which deliver blood to liver, extrahepatic...
The diagnosis of graft-versus-host disease (GvHD) after liver transplantation can be difficult because early symptoms are often nonspecific. In this study, the presence donor lymphocyte macrochimerism in recipient peripheral blood was examined as a diagnostic aid for GvHD cadaveric transplantation.Between 1996 and 2002, 33 transplant recipients with clinical suspicion (skin rash, diarrhea, pyrexia, pancytopenia, or anemia, without an obvious alternative cause) were investigated...
Watson, Christopher J. E. MD; Randle, Lucy V.; Kosmoliaptsis, Vasilis PhD; Gibbs, Paul Allison, Michael Butler, Andrew MChir Author Information