A5069877095- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Gallbladder and Bile Duct Disorders
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Liver Disease and Transplantation
- Renal cell carcinoma treatment
- Liver physiology and pathology
- Pediatric Hepatobiliary Diseases and Treatments
- Gastrointestinal Tumor Research and Treatment
- Organ Transplantation Techniques and Outcomes
- Gastrointestinal disorders and treatments
- Colorectal Cancer Surgical Treatments
- Neuroendocrine Tumor Research Advances
- Intestinal Malrotation and Obstruction Disorders
- Esophageal and GI Pathology
- Diverticular Disease and Complications
- Cancer Genomics and Diagnostics
- Metastasis and carcinoma case studies
- Bariatric Surgery and Outcomes
- Colorectal Cancer Screening and Detection
- Hernia repair and management
Fondazione Poliambulanza Istituto Ospedaliero
2016-2025
IRCCS San Camillo Hospital
2021
University of Rome Tor Vergata
2021
Agostino Gemelli University Polyclinic
2016
Università Cattolica del Sacro Cuore
2016
The University of Texas MD Anderson Cancer Center
2012-2015
Ospedale D. Cotugno
2015
Oslo University Hospital
2015
Ospedale Garibaldi
2015
Ospedali Riuniti Umberto I
2009-2014
To determine the impact of RAS mutation status on survival and patterns recurrence in patients undergoing curative resection colorectal liver metastases (CLM) after preoperative modern chemotherapy.RAS has been reported to be associated with aggressive tumor biology. However, effect CLM remains unclear.Somatic mutations were analyzed using mass spectroscopy 193 who underwent single-regimen chemotherapy before CLM. The relationship between outcomes was investigated.Detected somatic included...
To determine the prognostic impact of tumor location in gallbladder cancer.Depth is a strong predictor survival after curative resection cancer. However, has unique anatomical relationship with liver, and clinical significance remains unclear.For 437 patients cancer who underwent at 4 international institutions, clinicopathologic characteristics their association were analyzed. Tumor was defined as "hepatic side" or "peritoneal side," evaluated.Among 252 T2 disease, tumors on hepatic side...
Textbook outcome (TO) is a composite measure that captures the most desirable surgical outcomes as single indicator, yet to date TO has not been defined and assessed in field of laparoscopic liver resection (LLR) open (OLR).To obtain international agreement on definition surgery (TOLS) assess incidence LLR OLR large multicenter database using propensity-score matched analysis.Patients undergoing or for all diseases between January 2011 October 2019 were analyzed database. An survey was...
Objective: The aim of this study was to compare the perioperative outcomes robotic liver surgery (RLS) and laparoscopic (LLS) in various settings. Summary Background Data: Clear advantages RLS over LLS have rarely been demonstrated, associated costs are generally higher than those surgery. Therefore, exact role approach minimally invasive remains be defined. Methods: In international retrospective cohort study, patients who underwent for all indications between 2009 2021 34 hepatobiliary...
Purpose The purposes of this study were to confirm the prognostic value an optimal morphologic response preoperative chemotherapy in patients undergoing with or without bevacizumab before resection colorectal liver metastases (CLM) and identify predictors response. Patients Methods included 209 who underwent CLM after oxaliplatin- irinotecan-based regimens bevacizumab. Radiologic responses classified as suboptimal according criteria. Overall survival (OS) was determined, factors associated...
In Brief Objective: To determine the impact of surgical margin status on overall survival (OS) patients undergoing hepatectomy for colorectal liver metastases after modern preoperative chemotherapy. Background: era effective chemotherapy metastases, association between and has become controversial. Methods: Clinicopathologic data outcomes 378 treated with were analyzed. The effect positive margins OS was analyzed in relation to pathologic computed tomography–based morphologic response...
Background After cancer surgery, complications, and disability prevent some patients from receiving subsequent treatments. Given that an inability to complete all intended therapies might negate the oncologic benefits of surgical therapy, strategies improve return treatment (RIOT), including minimally invasive surgery (MIS), are being investigated. Methods This project was designed evaluate liver tumor determine RIOT rate, risk factors for RIOT, its impact on survivals. Outcomes a homogenous...
Objective: To investigate the legitimacy of 90-day mortality as a measure hepatopancreatobiliary quality. Background: The rate has been increasingly but not universally reported after surgery. this definition surgical quality evaluated. Methods: We retrospectively reviewed causes all deaths that occurred within 365 postoperative days in patients undergoing hepatectomy (n = 2811) and/or pancreatectomy 1092) from January 1997 to December 2012. rates surgery-related, disease-related, and...
Abstract Background Most patients requiring an extended right hepatectomy (ERH) have inadequate standardized future liver remnant (sFLR) and need preoperative portal vein embolization (PVE). However, the clinical oncological impact of PVE in such remains unclear. Methods All consecutive presenting at M. D. Anderson Cancer Center with colorectal metastases (CLM) ERH presentation from 1995 to 2012 were studied. Surgical outcomes compared between adequate sFLRs presentation. Results Of 265 ERH,...
Background: Metabolic syndrome (MS) is rapidly growing as risk factor for HCC. Liver resection HCC in patients with MS associated increased postoperative risks. There are no data on factors complications. Aims: The aim was to identify and develop validate a model major morbidity after liver MS, using large multicentric Western cohort. Materials Methods: univariable logistic regression analysis applied select predictive 90 days morbidity. built the multivariable presented nomogram....
In Brief Objective: We hypothesized that metachronous colorectal liver metastases (CLM) have different biology after failure of oxaliplatin (FOLFOX) compared to 5-fluorouracil (5-FU) or no chemotherapy for adjuvant treatment cancer (CRC). Background: It is unclear whether patients treated with resection CLM FOLFOX CRC worse outcomes than those who received 5-FU chemotherapy. Methods: identified 341 underwent hepatectomy (disease-free interval ≥12 months, 1993–2010). Mass-spectroscopy...
Clear indications on how to select retreatments for recurrent hepatocellular carcinoma (HCC) are still lacking.To create a machine learning predictive model of survival after HCC recurrence allocate patients their best potential treatment.Real-life data were obtained from an Italian registry between January 2008 and December 2019 median (IQR) follow-up 27 (12-51) months. External validation was made derived by another cohort Japanese cohort. Patients who experienced first surgical approach...
Abstract Background This study aimed to assess the best achievable outcomes in laparoscopic liver resection (LLR) after risk adjustment based on surgical technical difficulty using a national registry. Methods LLRs registered Italian Group of Minimally Invasive Liver Surgery registry from November 2014 March 2018 were considered. Benchmarks calculated according Achievable Benchmark Care (ABC™). at each centre divided into three clusters (groups I, II and III) Kawaguchi classification. ABCs...