A5103011127- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Liver Disease and Transplantation
- Esophageal Cancer Research and Treatment
- Organ Transplantation Techniques and Outcomes
- Liver Disease Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Pancreatitis Pathology and Treatment
- Metastasis and carcinoma case studies
- Esophageal and GI Pathology
- Renal cell carcinoma treatment
- Cancer Genomics and Diagnostics
- Gastrointestinal Tumor Research and Treatment
- Gallbladder and Bile Duct Disorders
- Colorectal Cancer Surgical Treatments
- Tissue Engineering and Regenerative Medicine
- Multiple and Secondary Primary Cancers
- Electrospun Nanofibers in Biomedical Applications
- Liver physiology and pathology
- Pancreatic function and diabetes
- Viral-associated cancers and disorders
- Renal Transplantation Outcomes and Treatments
University Hospital Münster
2023-2025
Charité - Universitätsmedizin Berlin
2014-2023
Freie Universität Berlin
2019-2023
Humboldt-Universität zu Berlin
2019-2023
Royal United Hospital
2023
Klinik und Poliklinik für Psychosomatik und Psychotherapie
2023
University Hospital of Bern
2020-2022
University of Bern
2020-2022
Universitätsmedizin Rostock
2021
MSB Medical School Berlin
2017-2020
Prolonged survival after two-stage resection (TSR) of advanced colorectal liver metastases (CLM) may be the result selection best responders to chemotherapy. The impact complete in this well-selected group is controversial.Data on 890 patients undergoing and 879 who received only chemotherapy for CLM were collected prospectively. We used intent-to-treat analysis evaluate underwent TSR. Additionally, we evaluated a cohort nonsurgically treated selected mirror TSR population: with liver-only...
To determine the impact of RAS mutation status on survival and patterns recurrence in patients undergoing curative resection colorectal liver metastases (CLM) after preoperative modern chemotherapy.RAS has been reported to be associated with aggressive tumor biology. However, effect CLM remains unclear.Somatic mutations were analyzed using mass spectroscopy 193 who underwent single-regimen chemotherapy before CLM. The relationship between outcomes was investigated.Detected somatic included...
In Brief Objective: To determine the impact of surgical margin status on overall survival (OS) patients undergoing hepatectomy for colorectal liver metastases after modern preoperative chemotherapy. Background: era effective chemotherapy metastases, association between and has become controversial. Methods: Clinicopathologic data outcomes 378 treated with were analyzed. The effect positive margins OS was analyzed in relation to pathologic computed tomography–based morphologic response...
With excellent short-term survival in liver transplantation (LT), we now focus on long-term outcome and report the first European single-center 20-year data. Three hundred thirty-seven LT were performed 313 patients (09/88-12/92). Impact was studied a comparison to life expectancy of matched normal population performed. A detailed analysis 20-years follow-up concerning overweight (HBMI), hypertension (HTN), diabetes (HGL), hyperlipidemia (HLIP) moderately or severely impaired renal function...
Tumor mutational burden (TMB: somatic mutations per megabase, mut/Mb) predicts the efficacy of immunotherapy. Here, we link TMB levels with activation immune pathways and intratumoral responses in pancreatic adenocarcinoma (PDAC) to explore immunoarchitectural patterns associated high TMB.We assessed 161 resected, microsatellite stable (MSS) PDACs, including 41 long-term survivors (LTS). Five instable (MSI-high) cases were also assessed. Cases classified into TMB-high (≥10 mut/Mb),...
Introduction. Although ampullary carcinoma has the best prognosis among all periampullary carcinomas, its long-term survival remains low. Prognostic factors are only available for a period of 10 years after pancreaticoduodenectomy. The aim this retrospective study was to identify that influence patient over 15-year observation period. Methods. From 1992 2007, 143 patients with underwent pancreatic resection. 86 pylorus-preserving pancreaticoduodenectomy (60%) and 57 standard Kausch-Whipple...
Decellularization of pancreata and repopulation these non-immunogenic matrices with islets endothelial cells could provide transplantable, endocrine Neo- Pancreata. In this study, rat were perfusion decellularized repopulated intact islets, comparing three routes (Artery, Portal Vein, Pancreatic Duct). effectively removed all cellular components but conserved the pancreas specific extracellular matrix. Digital subtraction angiography showed a integrity vascular system contrast emersion into...
In Brief Objective: We hypothesized that metachronous colorectal liver metastases (CLM) have different biology after failure of oxaliplatin (FOLFOX) compared to 5-fluorouracil (5-FU) or no chemotherapy for adjuvant treatment cancer (CRC). Background: It is unclear whether patients treated with resection CLM FOLFOX CRC worse outcomes than those who received 5-FU chemotherapy. Methods: identified 341 underwent hepatectomy (disease-free interval ≥12 months, 1993–2010). Mass-spectroscopy...
BackgroundResection margin status has traditionally been associated with tumor recurrence and oncological outcome following liver resection for colorectal metastases. Previous studies, however, did not address the impact of on site differentiate between true local at elsewhere in liver. This study aimed to determine whether positive margins surgical influences long-term survival.MethodsClinicopathological data outcomes patients who underwent curative metastases 2012 2017 2 major...
Abstract We assessed the performance of factory‐calibrated, sixth‐generation continuous glucose monitoring (CGM) system Dexcom G6® (DexCom Inc., San Diego, California) during elective abdominal surgery. Twenty adults with (pre)diabetes undergoing surgery (>2 hours; 15 men, age 69 ± 13 years, glycated haemoglobin 53 14 mmol/mol) wore sensor from 1 week prior to until hospital discharge. From induction anaesthesia 2 hours post‐surgery, reference capillary values were obtained every 20...
Background: Despite recent advances in the field of laparoscopic liver surgery, intrahepatic cholangiocarcinoma (iCC) as an entity has been nearly exempted from new approaches because proposed technical difficulties achieving lymphadenectomy (LAD) and beneficial oncologic outcomes. Materials Methods: Clinical courses all consecutive patients (n = 159) undergoing resection for iCC at Department Surgery, Charité—Universitätsmedizin between January 2015 October 2019 were studied. Ultimately,...
Modern chemotherapy and repeat hepatectomy allow to tailor the surgical strategies for treatment of colorectal liver metastases (CRLM). This study addresses hypothesis that parenchymal-sparing reduces postoperative complications while ensuring similar oncologic outcomes compared standardized non-parenchymal-sparing procedures.Clinicopathological data patients who underwent resection CRLM between 2012 2019 at a hepatobiliary center in Switzerland were assessed. Patients stratified according...
Background: According to current guidelines, preoperative endoscopic retrograde cholangiopancreatography (ERCP) with biliary stenting (ERCP/stenting) is often necessary in patients obstructive jaundice due pancreatic ductal adenocarcinoma (PDAC), including severe (bilirubin > 250 umol/l), pruritus, cholangitis, cholestatic liver dysfunction, renal failure, malnutrition, or delayed surgery for tumors requiring neoadjuvant chemotherapy. We aimed investigate the impact of ERCP/stenting on...