A5020247147- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Nanoplatforms for cancer theranostics
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune cells in cancer
- Organ Transplantation Techniques and Outcomes
- Liver Disease Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
- Immune Response and Inflammation
- Nitric Oxide and Endothelin Effects
- Colorectal Cancer Treatments and Studies
- Liver Disease and Transplantation
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Gastric Cancer Management and Outcomes
- Pediatric Hepatobiliary Diseases and Treatments
- Colorectal and Anal Carcinomas
- Inflammatory Biomarkers in Disease Prognosis
- Renal Transplantation Outcomes and Treatments
- Cancer Genomics and Diagnostics
- Inflammatory mediators and NSAID effects
- Cancer survivorship and care
- Eicosanoids and Hypertension Pharmacology
- Tissue Engineering and Regenerative Medicine
University of Pittsburgh Medical Center
2016-2025
University of Pittsburgh
2015-2024
Northwell Health
2024
Directorate-General for Interpretation
2022
Creative Commons
2021
Memorial Sloan Kettering Cancer Center
2021
Mayo Clinic in Florida
2021
WinnMed
2021
UPMC Montefiore
2020
UPMC Presbyterian
2019
Abstract Risks of tumor recurrence after surgical resection have been known for decades, but the mechanisms underlying treatment failures remain poorly understood. Neutrophils, first-line responders stress, may play an important role in linking inflammation to cancer progression. In response neutrophils can expel their protein-studded chromatin form local snares as neutrophil extracellular traps (NET). this study, we asked whether, a result its ability ensnare moving cells, NET formation...
Innate immunity plays a crucial role in the response to sterile inflammation such as liver ischemia/reperfusion (I/R) injury. The initiation of I/R injury results release damage‐associated molecular patterns, which trigger an innate immune and inflammatory cascade through pattern recognition receptors. Neutrophils are recruited after contribute organ damage responses. Formation neutrophil extracellular traps (NETs) has been recently found various stimuli. However, NETs during remains...
Nonalcoholic steatohepatitis (NASH) is a progressive, inflammatory form of fatty liver disease. It the most rapidly rising risk factor for development hepatocellular carcinoma (HCC), which can arise in NASH with or without cirrhosis. The signals promoting progression to HCC remain largely unknown. propensity neutrophils expel decondensed chromatin embedded proteins, known as neutrophil extracellular traps (NETs), has been shown be important chronic conditions and cancer progression. In this...
To perform a matched comparison of surgical and postsurgical outcomes between our robotic laparoscopic hepatic resection experience.The application technology technique to liver surgery has grown. Robotic methods may have the potential overcome certain disadvantages, but few studies drawn resections.Demographics, intraoperative variables, postoperative among patients undergoing (n = 57) 114) resections November 2007 December 2011 were reviewed. A 1:2 analysis was performed by individually...
Neutrophil infiltration and neutrophil extracellular traps (NET) in solid cancers are associated with poorer prognosis, but the mechanisms incompletely understood. We hypothesized that NETs enhance mitochondrial function tumor cells, providing extra energy for accelerated growth. Metastatic colorectal cancer tissue showed increased intratumoral supranormal preoperative serum MPO-DNA, a NET marker. Higher MPO-DNA correlated shorter survival. In mice, subcutaneous implants hepatic metastases...
While neutrophil extracellular traps (NETs) are important for directly promoting cancer growth, little is known about their impact on immune cells within the tumor microenvironment (TME). We hypothesize that NETs can interact with infiltrating T to promote an immunosuppressive TME. Herein, induce a NET-rich TME, we performed liver Ischemia/Reperfusion (I/R) in established metastasis model or injected subcutaneous tumors. In this majority of CD4+ and CD8+ lymphocytes expressed multiple...
The ability of cancer cells to survive and grow under hypoxic conditions has been known for decades, but the mechanisms remain poorly understood. Under certain conditions, undergo changes in their bioenergetic profile favor mitochondrial respiration by activating peroxisome proliferator–activated receptor gamma coactivator 1 alpha (PGC‐1α) up‐regulating biogenesis. In this study, we hypothesized that augmented biogenesis plays a critical role hypoxia. Consistent with hypothesis, both human...
Neutrophils constitute the early innate immune response to perceived infectious and sterile threats. Neutrophil extracellular traps (NETs) are a novel mechanism counter pathogenic invasion sequelae of ischemia, including cell death oxidative stress. Superoxide is radical intermediate oxygen metabolism produced by parenchymal nonparenchymal hepatic cells, hallmark stress after liver ischemia-reperfusion (I/R). While superoxide recruits neutrophils initiates inflammatory injury, it unknown...
Toll-like receptor 4 (TLR4) is ubiquitously expressed on parenchymal and immune cells of the liver most studied TLR responsible for activation proinflammatory signaling cascades in ischemia reperfusion (I/R). Since pharmacological inhibition TLR4 during sterile inflammatory response I/R has not been studied, we sought to determine whether eritoran, a antagonist trialed sepsis, could block hepatic TLR4-mediated inflammation end organ damage. When C57BL/6 mice were pretreated with eritoran...
Robotic pancreatectomy is gaining momentum; however, limited data exist on the long-term survival of this approach for pancreatic ductal adenocarcinoma (PDAC). The objective study to compare oncologic outcomes robotic pancreaticoduodenectomy (RPD) and distal (RDP) open surgery in patients with PDAC.Robotic stages I-III PDAC were obtained from 2010 2016 National Cancer Database.We identified 17 831 pancreaticoduodenectomies 2718 pancreatectomies which 626 (4%) 332 (12%) robotic, respectively....
Time to surgery (TTS) is of concern patients diagnosed with cancer and their physicians. Controversy surrounds the impact TTS on colon survival. There are limited national data evaluating association; thus, our aim was estimate overall survival (OS) from increasing for cancer.Using National Cancer Data Base (NCDB), we assessed OS as a function time between diagnosis by intervals encompassing <7, 7 30, 31 60, 61 90, 91 120, 121 180 days in length. All were nonmetastatic underwent initial...
Background: Metabolic syndrome (MS) is rapidly growing as risk factor for HCC. Liver resection HCC in patients with MS associated increased postoperative risks. There are no data on factors complications. Aims: The aim was to identify and develop validate a model major morbidity after liver MS, using large multicentric Western cohort. Materials Methods: univariable logistic regression analysis applied select predictive 90 days morbidity. built the multivariable presented nomogram....