A5101801163- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Liver Disease Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Gallbladder and Bile Duct Disorders
- Pancreatitis Pathology and Treatment
- Neuroendocrine Tumor Research Advances
- Liver Disease and Transplantation
- Multiple and Secondary Primary Cancers
- Gastrointestinal Tumor Research and Treatment
- Biliary and Gastrointestinal Fistulas
- Pediatric Hepatobiliary Diseases and Treatments
- Organ Transplantation Techniques and Outcomes
- Cancer Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Viral-associated cancers and disorders
- Gastrointestinal disorders and treatments
- Liver physiology and pathology
- Genetic and Kidney Cyst Diseases
- Colorectal Cancer Treatments and Studies
- Head and Neck Cancer Studies
- Colorectal and Anal Carcinomas
- Abdominal vascular conditions and treatments
- Hepatitis B Virus Studies
Osaka City General Hospital
2016-2025
Chiba University Hospital
2014-2019
Chiba University
2013
Hokkaido Science Education Center
2008
Osaka City University
1994-2006
Showa General Hospital
2000-2002
Juntendo University
2001
Laparoscopic liver resection for hepatocellular carcinoma (HCC) in Child-Pugh A cirrhosis has been demonstrated as beneficial. However, the role of laparoscopy B is undetermined. The aim this retrospective cohort study was to compare open and laparoscopic HCC with cirrhosis.Data on resections were gathered from 17 centres. 1 : propensity score matching performed according predefined variables.Of 382 available resections, 100 matched analysed. 90-day postoperative mortality rate similar...
The response rate to sorafenib in hepatocellular carcinoma (HCC) is relatively low (0.7%-3%), however, rapid and drastic tumor regression occasionally observed. molecular backgrounds clinico-pathological features of these responders remain largely unclear. We analyzed the clinical 13 with significant shrinkage a retrospective study. A comparative genomic hybridization analysis using one frozen HCC sample from responder demonstrated that 11q13 region, rare amplicon including loci for FGF3...
Abstract Background In the absence of randomized controlled data and even propensity-matched data, indications for, outcomes of, laparoscopic repeat liver resection for hepatocellular carcinoma (HCC) remain uncertain. This study aimed to clarify current HCC, evaluate outcomes. Methods Forty-two surgery centres around world registered patients who underwent HCC. Patient characteristics, preoperative function, tumour surgical method, short- long-term were recorded. Results Analyses showed that...
Abstract Background It is still unknown whether laparoscopic liver resection suitable for recurrent hepatocellular carcinoma (HCC) after previous curative hepatic resection. Method The perioperative outcomes of 40 patients treated with second surgery HCC by partial hepatectomy were studied retrospectively. was performed under laparotomy in 20 (laparotomy group) and laparoscopy (laparoscopy group). Results Intraoperative blood loss ( p < 0.0001) the incidence postoperative complications =...
We report a case of gastric malignant schwannoma presenting with gastrointestinal bleeding.A 70-year-old Japanese man presented bleeding to our hospital. Gastrointestinal endoscopy revealed protruding lesion in the body. Hematoxylin and eosin staining biopsy specimens from this sheets spindle cells. Immunohistochemistry that these cells were positive for S-100 protein negative c-Kit smooth muscle actin. Because mitosis was diffusely visible, tumor diagnosed as schwannoma. Distal gastrectomy...
The multi-kinase inhibitor sorafenib is clinically approved for the treatment of patients with advanced hepatocellular carcinoma (HCC). We previously reported that fibroblast growth factor 3 and 4 (FGF3/FGF4) amplification a predictor response to sorafenib. This study aims analyze relationship between FGF-FGF receptor (FGFR) genetic alterations Formalin-fixed, paraffin-embedded tissue specimens from HCC who had achieved complete (CR, N=6) or non-CR (N=39) were collected examined FGF-FGFR...
Introduction We investigated the indications for laparoscopic liver resection (LLR) of mass‐forming intrahepatic cholangiocarcinoma (MF‐ICC), including need lymph node dissection improved postoperative prognosis. Methods This study involved 36 patients who underwent surgery solitary peripheral MF‐ICC. Fifteen LLR, and 21 open (OLR). Surgical outcomes prognostic factors were to determine LLR. Results No significant differences observed in perioperative between LLR OLR. A significantly worse...
Artificial intelligence (AI) is becoming more useful as a decision-making and outcomes predictor tool. We have developed AI models to predict surgical complexity the postoperative course in laparoscopic liver surgery for segments 7 8.
Liver resection is a widely preferred treatment modality for hepatocellular carcinomas (HCCs). This study aimed to compare the survival impact of anatomical with that limited resection, in patients single HCCs no larger than 5 cm diameter.A cohort was carried out on 209 consecutive who underwent hepatic HCC diameter between January 1994 and March 2007 at Osaka City General Hospital.The cumulative 5-year overall disease-free rates group (n = 111) were 71 40%, respectively, both which...
The purpose of this study was to retrospectively evaluate the incidence delayed renal dysfunction after total body irradiation (TBI) in long-term survivors TBI/hematopoietic stem cell transplantation (HSCT). Between 1989 and 2006, 24 pediatric patients underwent TBI as part conditioning regimen for HSCT at Chiba University Hospital. Nine who survived more than 5 years were enrolled study. No patient had any evidence prior transplant according their baseline creatinine levels. median age time...
Abstract Introduction This study aimed to investigate the predictive factors and classifications for difficulty of laparoscopic repeated liver resection (LRLR) in patients with recurrent hepatocellular carcinoma. Methods Sixty who underwent LRLR were included. Potential difficult included approach previous (laparoscopic or open), number resections, a history cholecystectomy resection, operative procedure whether tumor was near resected site non‐surgical treatments before present surgery,...
Less morbidity is considered among the advantages of laparoscopic liver resection (LLR) for HCC patients. However, our previous international, multi-institutional, propensity score-based study emerging repeat (LRLR) failed to prove this advantage. We hypothesize that these results may be since included complex LRLR cases performed during procedure’s developing stage. To examine it, subgroup analysis based on score were performed, defining proximity tumors major vessels as indicator cases....
Unlike normal liver with the sinusoids, hepatocellular carcinomas (HCCs) possess capillaries. Whether these capillaries derive from sinusoids remains unclear in human HCCs. This study aimed to examine sinusoidal capillarization HCCs and its relationship tumor size, arterialization dedifferentiation. Thirty-eight a diameter of 10 - 140 mm were pathologically angiographically examined. By electron microscopy, microvasculature tumors was classified into sinusoidal, intermediate capillary types,...