A5068323050- Dementia and Cognitive Impairment Research
- Sports Performance and Training
- Frailty in Older Adults
- Muscle metabolism and nutrition
- Functional Brain Connectivity Studies
- Nutrition and Health in Aging
- Cardiovascular and exercise physiology
- Blood Pressure and Hypertension Studies
- Balance, Gait, and Falls Prevention
- Peripheral Artery Disease Management
- Cardiovascular Disease and Adiposity
- Dietetics, Nutrition, and Education
- Immune cells in cancer
- Physical Activity and Health
- Aging and Gerontology Research
- Children's Physical and Motor Development
- Memory and Neural Mechanisms
- Body Composition Measurement Techniques
- Organ Transplantation Techniques and Outcomes
- Cardiovascular Health and Disease Prevention
- Gastric Cancer Management and Outcomes
- Diet and metabolism studies
- Stroke Rehabilitation and Recovery
- Nutrition, Genetics, and Disease
- Heart rate and cardiovascular health
Centre for Inflammation Research
2024
University of Edinburgh
2024
The University of Sydney
2011-2022
Sydney Local Health District
2022
University of Otago
2018
Cheltenham General Hospital
2007
Physical and cognitive exercise may prevent or delay dementia in later life but the neural mechanisms underlying these therapeutic benefits are largely unknown. We examined structural functional magnetic resonance imaging (MRI) brain changes after 6 months of progressive resistance training (PRT), computerized (CCT) combined intervention. A total 100 older individuals (68 females, average age=70.1, s.d.±6.7, 55–87 years) with prodrome mild impairment were recruited SMART (Study Mental...
Abstract The liver has a unique ability to regenerate 1,2 ; however, in the setting of acute failure (ALF), this regenerative capacity is often overwhelmed, leaving emergency transplantation as only curative option 3–5 . Here, advance understanding human regeneration, we use paired single-nucleus RNA sequencing combined with spatial profiling healthy and ALF explant livers generate single-cell, pan-lineage atlas regeneration. We uncover novel ANXA2 + migratory hepatocyte subpopulation, which...
To determine whether improvements in aerobic capacity (VO2peak ) and strength after progressive resistance training (PRT) mediate cognitive function.Randomized, double-blind, double-sham, controlled trial.University research facility.Community-dwelling older adults (aged ≥55) with mild impairment (MCI) (N = 100).PRT (CT), 2 to 3 days per week for 6 months.Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-Cog); global, executive, memory domains; peak (1 repetition maximum);...
Dementia affects 47 million individuals worldwide, and assuming the status quo is projected to rise 150 by 2050. Prevention of age-related cognitive impairment in older persons with lifestyle interventions continues garner evidence but whether this can combat underlying neurodegeneration unknown. The Study Mental Activity Resistance Training (SMART) trial has previously reported within-training findings; aim study was investigate long-term neurostructural impact resistance exercise Mild...
Abstract Background In the absence of randomized controlled data and even propensity-matched data, indications for, outcomes of, laparoscopic repeat liver resection for hepatocellular carcinoma (HCC) remain uncertain. This study aimed to clarify current HCC, evaluate outcomes. Methods Forty-two surgery centres around world registered patients who underwent HCC. Patient characteristics, preoperative function, tumour surgical method, short- long-term were recorded. Results Analyses showed that...
The extent to which mental and physical exercise may slow cognitive decline in adults with early signs of impairment is unknown. This article provides the rationale methodology first trial investigate isolated combined effects training (CT) progressive resistance (PRT) on general function functional independence older impairment: Study Mental Regular Training (SMART). Our secondary aim quantify differential adaptations these interventions terms brain morphology function, cardiovascular...
Amirthalingam, T, Mavros, Y, Wilson, GC, Clarke, JL, Mitchell, L, and Hackett, DA. Effects of a modified German volume training program on muscular hypertrophy strength. J Strength Cond Res 31(11): 3109-3119, 2017-German Volume Training (GVT), or the 10 sets method, has been used for decades by weightlifters to increase muscle mass. To date, no study directly examined adaptations after GVT. The purpose this was investigate effect GVT intervention Nineteen healthy men were randomly assign 6...
This study investigated the effect of a 12-week modified German Volume Training intervention, or 10 sets method, on muscle strength and hypertrophy. Twelve healthy males were randomly assigned to either 5-SET 10-SET group performed 5 sets, respectively, repetitions at 60⁻80% one-repetition maximum (1RM). Muscle body composition measures taken baseline, six weeks, after 12 weeks training. No significant changes in total, trunk, arm lean mass found within between groups any time point. There...
Abstract Dementia is a leading cause of morbidity and mortality without pharmacologic prevention or cure. Mounting evidence suggests that adherence to Mediterranean dietary pattern may slow cognitive decline, important characterise in at-risk cohorts. Thus, we determined the reliability validity Diet Culinary Index (MediCul), new tool, among community-dwelling individuals with mild impairment (MCI). A total sixty-eight participants (66 % female) aged 75·9 ( sd 6·6) years, from Study Mental...
An active cognitive lifestyle has been suggested to have a protective role in the long-term maintenance of cognition. Amongst healthy older adults, more managerial or supervisory experiences midlife are linked slower hippocampal atrophy rate late life. Yet whether similar links exist individuals with Mild Cognitive Impairment (MCI) is not known, nor these differences any functional implications. 68 volunteers from Sydney SMART Trial, diagnosed non-amnestic MCI, were divided into high and low...
Aim: To investigate whether the amount and distribution of lean body mass fat is associated with disease severity in adults Charcot-Marie Tooth.Methods: Ten participants (age 46 ± 13 y, height 1.7 0.1 m, 77 17 kg) Tooth were involved this study. Participants evaluated for quality life, falls efficacy, balance, mobility, muscle strength, power. Body composition was measured using dual energy x-ray absorptiometry. Statistical analyses conducted on subsets all participants.Results: Better...
Osteoarthritis (OA) is one of the most prevalent chronic conditions among older adults, with medial tibio-femoral joint being frequently affected. The knee adduction moment recognized as a surrogate measure compartment load and therefore represents valid intervention target. This article provides rationale methodology for THE LO study (Train High, Eat Low Osteoarthritis), which randomized controlled trial that investigating effects unique, targeted lifestyle in overweight/obese adults...
Introduction Epidemiological evidence suggests that both poor cardiovascular fitness and low muscle mass or strength markedly increase the rate of cognitive decline incident dementia in older adults. Results from exercise trials for improvement cognition adults with mild impairment (MCI) have reported mixed results. This is possibly due to insufficient intensities. The aim Balance, Resistance, And INterval (BRAIN) Training Trial determine effects two forms exercise, high-intensity aerobic...
Longitudinal research on training and dietary practices of natural powerlifters is limited. This study investigated the effect phases physical physiological parameters in male powerlifters. Nine participants completed testing at two time points: (i) preparatory phase (~3 months prior to a major competition) (ii) competition (1-2 weeks from competition). No significant changes between were found for muscle strength power. A trend significance was decreased endurance lower body (-24.4%, p =...
Previous research has shown that kettlebell swings (KBS), utilizing the hip-hinge technique, exhibit similar lower-limb muscle activation patterns to sprint running. This study investigated whether inclusion of KBS in warm-up enhances performance. Moderately trained males (n = 12) and females 8) performed a control (CON) condition (passive rest) random order before performing three 20-m trials separated by 4 minutes. No (KBS versus CON) effects, time effects or interactions were found for...
Cognitive and physical exercise may reduce risk of dementia in mild cognitive impairment (MCI) but the underlying mechanisms are poorly understood. The SMART is a longitudinal randomised controlled trial that compares benefits isolated combined progressive resistance computerised training MCI. Previously, we revealed therapeutically relevant structural functional brain changes immediately after cessation1, however, no effects were found on hippocampal structure. Here, for first time,...
ABSTRACT Background Individuals with Mild Cognitive Impairment (MCI) have more gait variability under dual-task conditions than cognitively healthy adults. However, characteristics associated this susceptibility of to stress are unknown. Methods Testing was performed at baseline in the Study Mental And Resistance Training (SMART). Ninety-three adults MCI (age 70±6.8 years; 66.6% female) a single- and walk (cognitive distractor=letter fluency), random order. Linear non-linear were measured...
PURPOSE: Muscle power declines with age and disease predicts functional impairment. Although effective in some other cohorts, the benefits of high intensity, velocity progressive resistance training (power training) on muscle strength, power, contraction lower limb function older adults type 2 diabetes has not been investigated. METHODS: 103 overweight/obese (>60 years) were randomized to receive intensity [80% peak strength (1RM)] or sham-exercise, 3 days per week for 1 year. Peak 1RM...