A5018642378- Innovations in Medical Education
- Growth Hormone and Insulin-like Growth Factors
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Clinical Reasoning and Diagnostic Skills
- Adipose Tissue and Metabolism
- Hormonal and reproductive studies
- Estrogen and related hormone effects
- Dialysis and Renal Disease Management
- Dental Trauma and Treatments
- Pituitary Gland Disorders and Treatments
- Nutrition and Health in Aging
- Medical Education and Admissions
- Housing, Finance, and Neoliberalism
- Body Composition Measurement Techniques
- Diet and metabolism studies
- Injury Epidemiology and Prevention
- Housing Market and Economics
- Blood Pressure and Hypertension Studies
- Airway Management and Intubation Techniques
- Diabetes Management and Research
- Reflective Practices in Education
- Problem and Project Based Learning
- Interprofessional Education and Collaboration
St George Hospital
2013-2024
UNSW Sydney
2015-2024
Sutherland Hospital
2015-2024
Washington University in St. Louis
2023
University of Glasgow
2010-2021
University College Cork
2016
Middlesex University
2014
University of St Andrews
2011
Jean Mayer Human Nutrition Research Center on Aging
2007
Tufts University
2007
Skeletal muscle wasting is common and insidious in patients who receive maintenance hemodialysis treatment for the management of ESRD. The objective this study was to determine whether 12 wk high-intensity, progressive resistance training (PRT) administered during routine could improve skeletal quantity quality versus usual care. Forty-nine (62.6 ± 14.2 yr; 0.3 16.7 yr on dialysis) were recruited from outpatient unit St. George Public Hospital (Sydney, Australia). Patients randomized PRT +...
The route of estrogen replacement therapy has a major impact on the growth hormone (GH)/insulin-like factor-I (IGF-I) axis. Estrogen administration by oral, but not transdermal route, reduces IGF-I and increases GH levels in postmenopausal women. To investigate whether these perturbations have metabolic consequences, we compared effects 24 wk each oral (Premarin 1.25 mg) (Estraderm 100TTS) energy metabolism body composition 18 women an open-label randomized crossover study. Energy...
Women have a higher proportion of body fat compared to men. However, women consume fewer kilojoules per kilogram lean mass and burn more preferentially during exercise with During gestation, store even greater amounts that cannot be solely attributed increased energy intake. These observations suggest the relationship between consumed utilised is different in men women. The reason for these sex differences metabolism not known; however, it may relate steroids, insulin resistance, or...
Summary OBJECTIVE Insulin like growth factor‐I (IGF‐I) levels in post‐menopausal women are reduced by oral administration of the synthetic oestrogen ethinyl oestradiol but increased transdermal delivery 17 β ‐oestradiol. Since these types different, aim this study was to clarify whether reduction IGF‐I is a specific effect or common other formulations. DESIGN Randomized cross‐over comparing one month treatment with (20 μ g), conjugated equine (1 25 mg Premarin) and valerate (2 mg). SUBJECTS...
To investigate changes in body composition after 12 months of high-intensity progressive resistance training (PRT) relation to insulin (IR) or glucose homeostasis older adults with type 2 diabetes.One-hundred three participants were randomized receive either PRT sham exercise 3 days per week for months. Homeostasis model assessment (HOMA2-IR) and glycosylated hemoglobin (HbA1c) used as indices IR homeostasis. Skeletal muscle mass (SkMM) total fat assessed using bioelectrical impedance....
ABSTRACT: Aim: A more precise understanding of the aetiology and sequelae muscle wasting in end‐stage renal disease (ESRD) is required for development effective interventions to target this pathology. Methods: We investigated 49 patients with ESRD (62.6 ± 14.2 years, 0.3–16.7 years on haemodialysis). Thigh cross‐sectional area (CSA), intramuscular lipid intermuscular adipose tissue (IMAT) were measured via computed tomography as indices quantity (i.e. CSA) quality IMAT). Additional health...
Reductions in skeletal muscle mass and increased adiposity are key elements the aging process pathophysiology of several chronic diseases. Systemic low grade inflammation associated with obesity has been shown to accelerate age-related decline muscle. The aim this investigation was determine effects 12 months progressive resistance training (PRT) on systemic inflammation, whether reductions were changes body composition. We hypothesized that following PRT older adults type 2 diabetes would...
Increased cardiovascular risk following preeclampsia is well established and there are signs of early aging 6 months postpartum. This study assessed whether blood pressure (BP) other measures abnormal 2 years postpartum in the same cohort to determine ongoing markers.
We compared body composition and energy metabolism in a cross-sectional study involving 21 GH-deficient (GHD) 29 normal adults. Fifteen subjects from each group were pair-matched for age, sex, height, weight. Comparison of by dual x-ray absorptiometry the 15 pairs showed that GHD had significantly greater fat mass (23.9 +/- 1.8 vs. 19.8 2.6 kg; P = 0.02), lower bone mineral content (2.6 0.1 2.9 0.06), fat-free soft tissue (FFSTM; 45.8 2.5 48.9 0.02). To determine which subcompartment changes...
Previous studies have shown that oral, but not transdermal, administration of estrogen stimulates GH secretion in postmenopausal women. Because impairs insulin action, the impact replacement therapy on carbohydrate metabolism may be influenced by route administration. The aim this study was to prospectively compare effects oral and transdermal glucose tolerance sensitivity In an open label, randomized, cross-over study, nine women were randomized patches (Estraderm-TTS 100) or conjugated...
To investigate whether GH is a regulator of body composition and energy metabolism in adult life, we have compared resting expenditure (REE) cross-sectional study 20 acromegalic normal subjects, pair-matched for sex, age, height, weight. In longitudinal study, 8 patients were also studied before after 12 weeks treatment [n = 6 during octreotide (100 micrograms, 3 times/day); n 2 pituitary surgery], 7 withdrawal octreotide. REE was measured by indirect calorimetry fat mass fat-free soft...
Objective : Amiodarone-induced thyrotoxicosis (AIT) is a challenging management problem, since patients treated with amiodarone invariably have underlying heart disease. Consequently, can significantly contribute to increased morbidity and mortality. The aim of this study was compare the clinical outcome hormone profiles AIT ( n = 60) those Graves’ 49) toxic multinodular goitre (MNG, 40). Design A retrospective in single institution conducted. Methods Data from over 12 years were collected....
Abstract Aims Chronic kidney disease patients overwhelm specialist services and can potentially be managed in the primary care (PC). Opportunistic screening of high risk (HR) follow‐up PC is most sustainable model care. A ‘virtual consultation’ (VC) instead traditional face to (F2F) consultations was used, aiming assess efficacy safety model. Methods Seventy were recruited from sites hospital clinics followed for 1 year. The HR (eGFR < 30 mL/min/1.73m 2 +/− albuminuria >30 mg/mmol/L)...
Background There is increased risk of hypertension, early cardiovascular disease, and premature mortality in women who have had preeclampsia. This study was undertaken to determine the upper limit normal blood pressure (BP) 6 months postpartum frequency with prior preeclampsia BP above these limits, as part P4 (Post‐Partum Physiology, Psychology Pediatric) follow‐up study. Methods Results measured by sphygmomanometer, 24‐hour ambulatory monitoring, non‐invasive central at 302 normotensive...
Background. Increased arterial stiffness is a marker of cardiovascular damage, even in the absence clinically apparent disease. It likely to become an important clinical tool risk assessment. Aims and methods. We studied group healthy subjects measured their by digital photoplethysmography. aimed obtain range values, investigated influence age, gender, race, body mass index, fasting lipids haemodynamic factors. Results. One hundred fifty‐two subjects, aged between 18 67 years, on no...
Professionalism is comprised of a set values and behaviours that underpin the social contract between public medical profession. Medical errors are reported to result in significant morbidity mortality in-part related underdeveloped professionalism.The aim was determine whether specific aspects professionalism were students.A questionnaire with 24 vignettes taken by Year 2, 4, 6 students their responses compared from practicing Academics.Second, fourth sixth students' differed Academics two...