A5000713287- Peripheral Neuropathies and Disorders
- Glioma Diagnosis and Treatment
- Bariatric Surgery and Outcomes
- Dialysis and Renal Disease Management
- Hormonal Regulation and Hypertension
- Multiple Myeloma Research and Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Hereditary Neurological Disorders
- Myasthenia Gravis and Thymoma
- Aortic aneurysm repair treatments
- Peripheral Nerve Disorders
- Cancer Treatment and Pharmacology
- Diet and metabolism studies
- Body Contouring and Surgery
- Nutrition and Health in Aging
- Immune cells in cancer
- Stress Responses and Cortisol
- MicroRNA in disease regulation
- Meningioma and schwannoma management
- Aortic Disease and Treatment Approaches
- Heart Rate Variability and Autonomic Control
- Pituitary Gland Disorders and Treatments
- Minimally Invasive Surgical Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Muscle activation and electromyography studies
University of Massachusetts Chan Medical School
2007-2025
UMass Memorial Health Care
2008-2025
UMass Memorial Medical Center
2005-2025
Newcastle University
2025
University of Mary Hardin–Baylor
2025
University of Pennsylvania
2021-2024
UNSW Sydney
2005-2024
St. George Hospital
1997-2024
Hospital of the University of Pennsylvania
2024
University of Calgary
2014-2023
We attempted to survey with serum protein electrophoresis all patients peripheral neuropathy of unknown cause presenting at our institution within 1 year determine the prevalence monoclonal proteins in this group. Eighty-four percent these were evaluated, and 10% had a protein. This figure was statistically different from that obtained two community studies literature. Because often present difficult diagnostic problems, is necessary evaluation cryptogenic neuropathies.
Skeletal muscle wasting is common and insidious in patients who receive maintenance hemodialysis treatment for the management of ESRD. The objective this study was to determine whether 12 wk high-intensity, progressive resistance training (PRT) administered during routine could improve skeletal quantity quality versus usual care. Forty-nine (62.6 ± 14.2 yr; 0.3 16.7 yr on dialysis) were recruited from outpatient unit St. George Public Hospital (Sydney, Australia). Patients randomized PRT +...
Glioblastomas (GBMs) are aggressive brain tumors characterized by extensive inter- and intratumor heterogeneity. Patient-derived models, such as organoids explants, have recently emerged useful models to study heterogeneity, although the extent which they can recapitulate GBM genomic features remains unclear. Here, we analyze bulk exome single-cell genome transcriptome profiles of 12 IDH wild-type GBMs, including two recurrent tumors, patient-derived explants (PDEs) gliomasphere (GS) lines...
To investigate the short-term effect (4 weeks) of oral appliance therapy for obstructive sleep apnea on blood pressure.Randomized, controlled, crossover trial.Multidisciplinary disorders clinic in a university teaching hospital.Sixty-one patients diagnosed with polysomnography (apnea hypopnea index > or = 10 per hour and at least 2 following symptoms--daytime sleepiness, snoring, witnessed apneas, fragmented sleep; age 20 years; minimum mandibular protrusion 3 mm).A advancement splint (MAS)...
Sixteen cases of osteosclerotic myeloma and peripheral neuropathy (SM-PN) were reviewed. The resembled chronic inflammatory-demyelinating polyneuropathy with predominantly motor disability, high CSF protein levels, low nerve conduction velocities. Twelve the 16 patients had detectable levels monoclonal serum proteins, all A light chains, but results other laboratory studies usually normal. Most also organomegaly, endocrine abnormalities, or both. Treatment solitary lesions tumoricidal...
The records of 20 patients with typical or sclerotic (sclerotic mixed and lytic) multiple myeloma peripheral neuropathy who were seen during a 13-year period analyzed to determine the natural history neuropathy. In 10 myeloma, clinical pattern was heterogeneous. Chemotherapy for did not affect had presented in relatively homogeneous manner, predominantly motor Tumoricidal radiation therapy localized plasmacytomas resulted pronounced improvement two patients, mild three, endocrine...
Abstract The records of 31 patients with primary systemic amyloidosis and peripheral neuropathy seen during a 17‐year period were analyzed to define the natural history neuropathy. Patients tended be older men painful, distal, symmetrical sensorimotor prominent autonomic features. Loss pain temperature sensation was frequently more striking than loss mechanoreception. Renal, cardiac, hematological, gastrointestinal dysfunction often overshadowed Clinical, neurophysiological,...
Abstract Primary glial tumors of the central nervous system, most commonly glioblastoma multiforme (GBM), are aggressive lesions with a dismal prognosis. Despite identification and isolation human brain tumor stem cells (BTSCs), characteristics that distinguish BTSCs from neural remain to be elucidated. We cultured isolated gliomas, using neurosphere culture understand their growth requirements. Both CD133+ CD133− adult GBM proliferated in absence exogenous mitogenic stimulation gave rise...
Somatic mutations in the catalytic domain of isocitrate dehydrogenase (IDH) 1/2 and accumulation oncometabolite 2-hydroxyglutarate (2-HG) appear to be among earliest events gliomagenesis may contribute malignant transformation. The lack cell lines with endogenous has been one major challenges studying IDH1/2-mutant glioma developing novel therapeutics for these tumors. Here, we describe isolation a brain tumor stem line (BT142) an R132H mutation IDH1, aggressive tumor-initiating capacity,...
Abstract The integrity of a cell’s proteome depends on correct folding polypeptides by chaperonins. chaperonin TCP-1 ring complex (TRiC) acts as obligate folder for >10% cytosolic proteins, including he cytoskeletal proteins actin and tubulin. Although its architecture how it recognizes substrates are emerging from structural studies, the subsequent fate inside TRiC chamber is not defined. We trapped endogenous human with (actin, tubulin) cochaperone (PhLP2A) at different stages,...
To evaluate the feasibility and potential benefits of hand-assisted laparoscopic surgery with HandPort System, a new device.In surgery, surgeon inserts hand into abdomen while pneumoperitoneum is maintained. The assists instruments helpful in complex cases.A prospective nonrandomized study was initiated participation 10 surgical centers. Surgeons were free to test device any situation where they expected advantage over conventional laparoscopy.Sixty-eight patients entered study. Operations...
Summary OBJECTIVE Insulin like growth factor‐I (IGF‐I) levels in post‐menopausal women are reduced by oral administration of the synthetic oestrogen ethinyl oestradiol but increased transdermal delivery 17 β ‐oestradiol. Since these types different, aim this study was to clarify whether reduction IGF‐I is a specific effect or common other formulations. DESIGN Randomized cross‐over comparing one month treatment with (20 μ g), conjugated equine (1 25 mg Premarin) and valerate (2 mg). SUBJECTS...
We describe four patients with a neuromuscular syndrome characterized by relatively isolated neck extensor weakness. EMG and muscle biopsies suggest restrictive noninflammatory myopathy predominantly affecting the cervical paraspinal muscles.
The electrodiagnostic findings in 51 patients with monoclonal serum proteins of different etiologies and peripheral neuropathies are analyzed the an additional 10 multiple myeloma discussed. nine gammopathy undetermined significance had patterns consistent either predominant axonal degeneration or demyelination. Almost all 15 osteosclerotic evidence a demyelinating neuropathy. 27 primary systemic amyloidosis almost always displayed neuropathy superimposed carpal tunnel syndrome some cases....