A5032790556- bioluminescence and chemiluminescence research
- Molecular Sensors and Ion Detection
- Advanced biosensing and bioanalysis techniques
- Receptor Mechanisms and Signaling
- Photoreceptor and optogenetics research
- Crystallization and Solubility Studies
- Click Chemistry and Applications
- X-ray Diffraction in Crystallography
- Peptidase Inhibition and Analysis
- Neuropeptides and Animal Physiology
- Ion channel regulation and function
- Protein Degradation and Inhibitors
- Cardiac electrophysiology and arrhythmias
- Luminescence and Fluorescent Materials
- Nanoplatforms for cancer theranostics
- Sulfur Compounds in Biology
- Computational Drug Discovery Methods
- Bacterial biofilms and quorum sensing
- Biosensors and Analytical Detection
- Histone Deacetylase Inhibitors Research
- Ubiquitin and proteasome pathways
- Supercapacitor Materials and Fabrication
- Nicotinic Acetylcholine Receptors Study
- Chemical Synthesis and Analysis
- Pharmacological Effects and Assays
Shandong University
2016-2025
Zhejiang University
2012-2025
Universidad de Londres
2025
Institute of Biophysics
2025
Chinese Academy of Sciences
2025
Hubei University
2025
Tufts University
2024
Soochow University
2023
State Key Laboratory of Microbial Technology
2009-2021
Blood Center of Zhejiang Province
2021
Abstract Store-operated Ca 2+ entry mediated by STIM1 and ORAI1 constitutes one of the major routes in mammalian cells. The molecular choreography STIM1–ORAI1 coupling is initiated endoplasmic reticulum (ER) store depletion with subsequent oligomerization ER-luminal domain, followed its redistribution towards plasma membrane to gate channels. mechanistic underpinnings this inside-out signalling were largely undefined. By taking advantage a unique gain-of-function mutation within...
Molecular docking, which is the indispensable emphasis in predicting binding conformations and energies of ligands to receptors, constructs high-throughput virtual screening available. So far, increasingly numerous molecular docking programs have been released, among them, AutoDock 4.2 a widely used program with exceptional accuracy. It has heretofore substantiated that calculation partial charge very fundamental for accurate conformation search energy estimation. However, no systematic...
Considering that hydrogen sulfide (H2S) is an endogenous signaling molecule involved in numerous biological processes, a method for monitoring H2S as powerful tool investigating its complicated functions and mechanisms urgently demanded. Herein, bioluminescent turn-on probe was reported based on caged strategy the detection of vitro vivo. This will help us understand intricate contribution to variety physiological pathological processes.
Enantioselective, intermolecular alkene arylamination was achieved through gold redox catalysis. Screening of ligands revealed chiral P,N as the optimal choice, giving aminoarylation with good yields (up to 80 %) and excellent stereoselectivity 99 : 1 er). As first example enantioselective catalysis, this work confirmed feasibility applying a ligand at gold(I) stage, stereodetermining step (SDS) gold(III) intermediate, thus opening up new way conduct catalysis stereochemistry control.
The first general method for the selection of boronic acid−based aptamers (boronolectins) that allows glycan substructure focusing is described. Using fibrinogen as a model glycoprotein, we have selected acid-modified DNA high affinities (low nM Kd) and ability to recognize changes in glycosylation site. developed should also be applicable development other glycoproducts, such glycolipids glycopeptides.
The 14-3-3 family of phosphoserine/threonine-recognition proteins engage multiple nodes in signaling networks that control diverse physiological and pathophysiological functions have emerged as promising therapeutic targets for such diseases cancer neurodegenerative disorders. Thus, small molecule modulators are much needed agents chemical biology investigations development. To analyze function modulate its activity, we conducted a screen identified...
Reactive oxygen species (ROS) often have significant roles in mediating redox modifications and other essential physiological processes, such as biological process regulation signal transduction. Considering that H2O2 is a substantial member of ROS, detection quantitation undertakes important but urgent responsibility. In this report, bioluminescent probe for detecting was well designed, synthesized, evaluated. This designed into three parts: H2O2-sensitive aryl boronic acid, aminoluciferin...
Abstract The N‐2‐aryl‐1,2,3‐triazole derivatives (NATs) were developed as a new class of UV/blue‐light‐emitting fluorophores. Though both N‐1‐aryl‐1,2,3‐triazoles and N‐2‐aryl‐1,2,3‐triazoles gave strong photo absorption under excitation at 330 nm, only the N‐2‐analogous showed fluorescence emission in UV/blue range with high efficiency various solvents (quantum yield Φ around 0.3–0.5). Significant substituted group effects observed, allowing tunable optical properties ( λ max ) from 350–400...
The triazole-Au (TA-Au) complexes were identified as effective chemoselective catalysts in promoting propargyl ester/ether 3,3-rearrangements. highly reactive allenes, which could not be isolated by simple cationic gold catalysts, prepared excellent yields (1% catalyst loading, >90% yields). Unlike other reported Au the TA-Au provided chirality transfer without racemization over a long period of time, giving enantioenriched allenes with stereoselectivity up to 99% ee).