A5063612088- Immunodeficiency and Autoimmune Disorders
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- Mycotoxins in Agriculture and Food
- Blood groups and transfusion
- Chronic Lymphocytic Leukemia Research
- Immunotherapy and Immune Responses
- Blood disorders and treatments
- Glycosylation and Glycoproteins Research
- Plant Disease Resistance and Genetics
- Plant Pathogens and Fungal Diseases
- Diabetes and associated disorders
- Asthma and respiratory diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- Cell Adhesion Molecules Research
- Peanut Plant Research Studies
- CAR-T cell therapy research
- Systemic Lupus Erythematosus Research
- Respiratory viral infections research
- Cardiomyopathy and Myosin Studies
- Cellular Mechanics and Interactions
- Immune Response and Inflammation
- Microtubule and mitosis dynamics
- Pneumonia and Respiratory Infections
Emory University
2022-2025
University of Alabama at Birmingham
2015-2024
Emory University Hospital
2020-2023
Ministry of Culture
2019-2021
National Sagamihara Hospital
2019-2021
Délégation Provence et Corse
2019-2020
University of Pennsylvania
2007-2012
University of New Orleans
2012
Czech Academy of Sciences, Institute of Microbiology
2005-2010
California University of Pennsylvania
2010
To better understand the stage(s) of differentiation reached by B-type chronic lymphocytic leukemia (B-CLL) cells and to gain insight into potential role antigenic stimulation in development diversification these cells, we analyzed rearranged VH genes expressed 83 B-CLL (64 IgM+ 19 non-IgM+). Our results confirm extend observations a bias use certain VH, D, JH among cells. In addition, they indicate that approximately 50% 75% non-IgM+ can exhibit somatic mutations. The presence mutation...
Diversification of the antibody repertoire in mammals results from a series apparently random somatically propagated gene rearrangement and mutational events. Nevertheless, it is well known that adult specificities acquired developmentally programmed fashion. As previously shown, segments encoding heavy-chain variable regions (V H ) mouse antibodies also ordered: number V rearranged B lymphocytes fetal mice small but increases progressively after birth. In this report, human B-lineage cells...
Developing T cells face a series of cell fate choices in the thymus and periphery. The role individual receptor (TCR) determining decisions remains unresolved. stochastic/selection model postulates that initial is independent TCR specificity, with survival dependent on additional TCR/coreceptor “rescue” signals. “instructive” holds initiated by interaction cognate peptide-MHC complex. are then segregated basis specificity aid critical coreceptors signal modulators [Chan S, Correia-Neves M,...
The ability to respond specific antigens develops in a programmed fashion. Although the antibody repertoire adults is presumably generated by stochastic combinatorial joining of rearranged heavy variable, diversity, and (VH-DH-JH) light (VL-JL) chains, experimental evidence mouse has shown nonrandom utilization variable gene segments during ontogeny response antigens. In this study, we have performed sequence analysis 104-day human fetal liver-derived, randomly isolated constant region C+ mu...
A number of non-HLA loci that have shown evidence (P < 0.05) for linkage with rheumatoid arthritis (RA) been previously identified. The present study attempts to confirm these findings.We performed a second genome-wide screen 256 new multicase RA families recruited from across the United States by North American Rheumatoid Arthritis Consortium. Affected sibling pair analysis on data set was using SIBPAL. We subsequently combined our first and sets in an attempt enhance linkages larger sample...
To assess the contribution of alternative pathway in complement activation and host defense its possible role regulation systemic energy balance vivo , factor D-deficient mice were generated by gene targeting. The mutant have no apparent abnormality development their body weights are similar to those D-sufficient littermates. Complement could not be initiated serum deficient activators rabbit erythrocytes zymosan. Surprisingly, injection cobra venom (CVF) caused a profound reproducible...
Antibodies are encoded by a limited number of germline gene segments that undergo somatic diversification through rearrangement and mutation. Because these mutation processes efficient, it is widely believed there little environmental selection pressure for the maintenance specific antibody sequences. We have performed pairwise comparisons known (as opposed to somatically generated) VH elements with hope identifying conserved structural features common sets segments. These studies reveal...
Gain-of-function (GOF) mutations in the signal transducer and activator of transcription 1 (STAT1) result unbalanced STAT signaling cause immune dysregulation immunodeficiency. The latter is often characterized by susceptibility to recurrent Candida infections, resulting clinical picture chronic mucocutaneous candidiasis (CMC). This study aims assess frequency GOF STAT1 a large international cohort CMC patients. was sequenced genomic DNA from 57 patients 35 healthy family members. functional...
We have proposed that significant subsets of individuals with IgA deficiency (IgA-D) and common variable immunodeficiency (CVID) may represent polar ends a clinical spectrum reflecting single underlying genetic defect. This proposal was supported by our finding these immunodeficiencies in high incidence C4A gene deletions C2 rare alleles. Here we present analysis the MHC haplotypes 12 IgA-D 19 CVID from 21 families 79 their immediate relatives. were defined analyzing polymorphic markers for...
Aflatoxins are absent from freshly harvested peanuts although Aspergillus flavus infest most of the kernels pods having visible openings. Microbial competition, governed by kernel moisture, limits aflatoxin content kernels. The toxins subject to microbial breakdown but amount broken down is initial concentration.
✓ In recent years, endoscopic third ventriculostomy has become a well-established procedure for the treatment of various forms noncommunicating hydrocephalus. Endoscopic is considered to be an easy and safe procedure. Complications have rarely been reported in literature. The authors present case which patient suffered fatal subarachnoid hemorrhage (SAH) after ventriculostomy. This 63-year-old man presented with confusion drowsiness was admitted hospital poor general condition. Computerized...