Robin Kobbe
A5069178443- Malaria Research and Control
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Immunodeficiency and Autoimmune Disorders
- Mosquito-borne diseases and control
- Pneumocystis jirovecii pneumonia detection and treatment
- Migration, Health and Trauma
- Long-Term Effects of COVID-19
- HIV/AIDS Research and Interventions
- Vaccine Coverage and Hesitancy
- Blood disorders and treatments
- Parasites and Host Interactions
- Respiratory viral infections research
- Travel-related health issues
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- COVID-19 Impact on Reproduction
- Immune responses and vaccinations
- Immune Cell Function and Interaction
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 detection and testing
- Dermatological diseases and infestations
- Global Maternal and Child Health
- COVID-19 and Mental Health
- Tuberculosis Research and Epidemiology
Universität Hamburg
2016-2025
University Medical Center Hamburg-Eppendorf
2016-2025
Bernhard Nocht Institute for Tropical Medicine
2005-2025
Klinik und Poliklinik für Kinder- und Jugendmedizin
2009-2024
Center for Discovery
2024
Hackensack Meridian Health
2024
German Center for Infection Research
2016-2024
Friedrich Schiller University Jena
2024
Jena University Hospital
2024
University of Oxford
2021
An outbreak caused by Shiga-toxin–producing Escherichia coli O104:H4 occurred in Germany May and June of 2011, with more than 3000 persons infected. Here, we report a cluster cases associated single family describe an open-source genomic analysis isolate from one member the family. This involved use rapid, bench-top DNA sequencing technology, data release, prompt crowd-sourced analyses. In less week, these studies revealed that strain belonged to enteroaggregative E. lineage had acquired...
Human tuberculosis (TB) is caused by members of the Mycobacterium complex (MTBC). The MTBC comprises several human-adapted lineages known as M. sensu stricto, well two (L5 and L6) traditionally referred to africanum. Strains L5 L6 are largely limited West Africa for reasons unknown, little their genomic diversity, phylogeography evolution. Here, we analysed genomes 350 320 strains, isolated from patients 21 African countries, plus 5 related that had not been classified into any lineages. Our...
In sub-Saharan Africa, malaria is a leading cause of morbidity and mortality among young children. Detailed knowledge spatial variation epidemiology associated risk factors important for planning evaluating malaria-control measures.The incidences socioeconomic were assessed over 21 months, from January 2003 to September 2005, in 535 children 9 villages small rural area with high Plasmodium falciparum transmission Ghana. Household positions mapped by use global positioning system, the effects...
Gain-of-function (GOF) mutations in the signal transducer and activator of transcription 1 (STAT1) result unbalanced STAT signaling cause immune dysregulation immunodeficiency. The latter is often characterized by susceptibility to recurrent Candida infections, resulting clinical picture chronic mucocutaneous candidiasis (CMC). This study aims assess frequency GOF STAT1 a large international cohort CMC patients. was sequenced genomic DNA from 57 patients 35 healthy family members. functional...
Non-canonical NF-κB-pathway signaling is integral in immunoregulation. Heterozygous mutations NFKB2 have recently been established as a molecular cause of common variable immunodeficiency (CVID) and DAVID-syndrome, rare condition combining deficiency anterior pituitary hormone with CVID. Here, we investigate 15 previously unreported patients primary (PID) from eleven unrelated families heterozygous NFKB2-mutations including eight the p.Arg853* nonsense mutation five harboring unique novel...
The transcription factor BCL11B is essential for development of the nervous and immune system, Bcl11b deficiency results in structural brain defects, reduced learning capacity, impaired cell mice. However, precise role humans largely unexplored, except a single patient with missense mutation, affected by multisystem anomalies profound deficiency. Using massively parallel sequencing we identified 13 patients bearing heterozygous germline alterations BCL11B. Notably, all them are global...
Children with human immunodeficiency virus type 1 (HIV-1) infection have limited options for effective antiretroviral treatment (ART).We conducted an open-label, randomized, noninferiority trial comparing three-drug ART based on the HIV integrase inhibitor dolutegravir standard care (non-dolutegravir-based ART) in children and adolescents starting first- or second-line ART. The primary end point was proportion of participants virologic clinical failure by 96 weeks, as estimated Kaplan-Meier...
ODYSSEY showed superior efficacy for dolutegravir-based antiretroviral therapy (ART) versus standard of care (SOC) in children living with HIV starting first-line or second-line ART aged 4 weeks older. Here, we aim to compare virological outcomes and resistance the dolutegravir group SOC up 96 weeks. was an open-label, multicentre, randomised, non-inferiority trial done 29 centres seven countries (Germany, Spain, South Africa, Thailand, UK, Uganda, Zimbabwe). recruited at least 28 days...
Primary antibody deficiencies (PADs) are the most frequent primary immunodeficiencies in human subjects. The genetic causes of PADs largely unknown. Sec61 translocon alpha 1 subunit (SEC61A1) is major complex, which main polypeptide-conducting channel endoplasmic reticulum membrane. SEC61A1 a target gene spliced X-box binding protein and strongly induced during plasma cell (PC) differentiation.We identified novel defect studied its pathologic mechanism 11 patients from 2 unrelated families...
Intermittent preventive antimalarial treatment in infants (IPTi) with sulfadoxine-pyrimethamine reduces falciparum malaria and anemia but has not been evaluated areas intense perennial transmission. It is unknown whether an additional the second year of life prolongs protection.A randomized, double-blinded, placebo-controlled trial administration therapy at 3, 9, 15 months age was conducted 1070 children area Ghana where holoendemic. Participants were monitored for 21 after recruitment...
Abstract SARS-CoV-2 is the causative agent of COVID-19 and a severe threat to global health. Patients infected with show wide range symptoms disease severity, while limited data available on its immunogenicity. Here, kinetics development SARS-CoV-2-specific antibody responses in relation clinical features dynamics specific B-cell populations are reported. Immunophenotyping B cells was performed by flow cytometry longitudinally collected PBMCs. In parallel, serum samples were analyzed for...
Predominantly antibody deficiencies (PAD) are a heterogeneous group of disorders characterized by dysfunctional production, low immunoglobulin levels in serum and impaired vaccine responses. The clinical picture is variable, ranging from mild symptoms to severe complications, which may include autoimmunity, gastrointestinal disease, allergy, malignancies. If left untreated, PAD patients at risk enduring disease progression, irreversible organ damage, reduced life expectancy. A timely...
Abstract Human parvovirus 4 has been considered to be transmitted only parenterally. However, after novel genotype 3 of was found in 2 patients with no parenteral risks, we tested infants Ghana. A viremia rate 8.6% over years indicates that this infection is common children Africa.
The identification and characterization of rare immune cell populations in humans can be facilitated by their growth advantage the context specific genetic diseases. Here, we use autoimmune lymphoproliferative syndrome to identify a population FAS-controlled TCRαβ+ T cells. They include CD4+, CD8+, double-negative cells defined CD38+CD45RA+T-BET− expression pattern. These unconventional are present healthy individuals, generated before birth, enriched lymphoid tissue, do not expand during...
So far, only a few reports about reinfections with SARS-CoV-2 have been published, and they often lack detailed immunological virological data. We report reinfection genetically distinct variant in an immunocompetent female healthcare worker that has led to mild disease course. No obvious viral escape mutations were observed the second virus variant. The infectious was shed from patient during infection episode despite presence of neutralizing antibodies her blood. Our data indicate moderate...
Vulnerability to infectious diseases in refugees is dependent on country of origin, flight routes, and conditions. Information specific medical needs different groups lacking. We assessed the prevalence diseases, immunity vaccine-preventable chronic conditions children, adolescents, adult from Ukraine who arrived Germany 2022. Using media, we recruited Ukrainian at 13 sites between 9-12/2022. An antigen test for acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection, serologies...