A5058556593- Antimicrobial Resistance in Staphylococcus
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- Tuberculosis Research and Epidemiology
- Bacterial biofilms and quorum sensing
- Streptococcal Infections and Treatments
- Pneumonia and Respiratory Infections
- HIV/AIDS drug development and treatment
- Antibiotic Resistance in Bacteria
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV-related health complications and treatments
- Mycobacterium research and diagnosis
- Immune Cell Function and Interaction
- Bacterial Identification and Susceptibility Testing
- T-cell and B-cell Immunology
- Antifungal resistance and susceptibility
- Antibiotic Use and Resistance
- Diagnosis and treatment of tuberculosis
- Bacterial Infections and Vaccines
- Hepatitis B Virus Studies
- Otolaryngology and Infectious Diseases
- Biochemical and Structural Characterization
- Hepatitis C virus research
- Viral Infections and Outbreaks Research
- Hemoglobinopathies and Related Disorders
Centre de Recherche Médicales de Lambaréné
2015-2024
Focus (Germany)
2022-2023
Albert Schweitzer Hospital
2011-2022
University of Tübingen
2012-2022
German Institute for Disaster Medicine
2022
German Center for Infection Research
2014-2020
Henry M. Jackson Foundation
2016
United States Department of Defense
2016
Universitätsklinikum Tübingen
2016
Amsterdam UMC Location University of Amsterdam
2015
Human tuberculosis (TB) is caused by members of the Mycobacterium complex (MTBC). The MTBC comprises several human-adapted lineages known as M. sensu stricto, well two (L5 and L6) traditionally referred to africanum. Strains L5 L6 are largely limited West Africa for reasons unknown, little their genomic diversity, phylogeography evolution. Here, we analysed genomes 350 320 strains, isolated from patients 21 African countries, plus 5 related that had not been classified into any lineages. Our...
Significance USA300 is a hypervirulent, community-acquired, multidrug-resistant Staphylococcus aureus clone that started to spread in the United States around 17 years ago. Many studies detected it also South America, Europe, and Asia-Pacific region. In this study, we show circulating sub-Saharan Africa. Locating temporal spatial origin of clonal lineages important with respect epidemiology molecular evolution pathogens. We evolved from less virulent resistant ancestor Central Europe 160...
ObjectivesCo-trimoxazole (trimethoprim/sulfamethoxazole) is clinically valuable in treating skin and soft tissue infections (SSTIs) caused by community-associated methicillin-resistant Staphylococcus aureus (MRSA). The genetic basis of emerging trimethoprim/sulfamethoxazole resistance S. from Africa unknown. Such knowledge essential to anticipate its further spread. We investigated the molecular epidemiology trimethoprim collected imported Africa.
Identification of basic prognostic indicators HIV infection is essential before widespread antiretroviral therapy can be implemented in low-technology settings. This study assessed how well body mass index (BMI:kg/m2) predicts survival.BMI within 3 months diagnosis was obtained from 1657 patients aged > or = 15 years, recruited a seroprevalent clinical cohort The Gambia since 1992 and followed up at least once. Baseline CD4+ counts assessment time were done.The mortality hazard ratio (HR)...
Abstract Background There have been no previous studies of the long-term survival and temporal changes in plasma viral load among HIV-2 infected subjects. Methods 133 158 HIV-uninfected subjects from a rural area North-west Guinea-Bissau, West Africa were enrolled into prospective cohort study 1991 followed-up to mid-2009. Data collected on four occasions during that period HIV antibodies, CD4% load. Results Median age (interquartile range [IQR]) at time enrollment was 47 (36, 60) years,...
Abstract Objectives SQ109, an asymmetrical diamine, is a novel anti-TB drug candidate. This first study in patients was done to determine safety, tolerability, pharmacokinetics and bacteriological effect of different doses SQ109 alone combination with rifampicin when administered over 14 days. Patients methods Smear-positive pulmonary TB were randomized into six groups 15 receive once-daily oral treatment 75, 150 or 300 mg (10 mg/kg body weight), plus for hospitalized supervised treatment,...
Abstract Background Physicians depend on reliable information the local epidemiology of infection and antibiotic resistance rates to guide empiric treatment in critically ill patients. As these data are scarce for Central Africa, we performed a retrospective analysis microbiological findings from secondary care hospital Gabon. Methods Microbiological reports 2009 2012 were used assess non-susceptibility three most common isolates six major types infections (bloodstream, ear-eye-nose-throat,...
Abstract Background Nosocomial infections pose substantial risk to patients receiving care in hospitals. In Africa, this problem is aggravated by inadequate infection control due poor hygiene, resource and structural constraints, deficient surveillance data lack of awareness regarding nosocomial infections. We carried out study determine the incidence spectrum infections, pathogens antibiotic resistance patterns a tertiary regional hospital Lambaréné, Gabon. Methods This prospective case was...
Objective To assess and compare the mortality rates of patients with HIV-1, HIV-2 or both infections (HIV-D) in same population. Design Clinic-based cohort study. Methods HIV-seropositive aged 15 years older who attended Medical Research Council clinics Fajara between May 1986 September 1997 were recruited. Clinical assessment using Karnofsky score, CDC cell staging, WHO CD4 counts was performed at baseline. Patients clinic every 3 months; if they did not attend, visited home by field...
Abstract Unlike HIV-1-infected people, most HIV-2-infected subjects maintain a healthy CD4+ T cell count and strong HIV-specific response. To define the cellular immunological correlates of good prognosis in HIV-2 infection, we conducted cross-sectional study HIV Gag-specific function HIV-1- Gambians. Using cytokine flow cytometry lymphoproliferation assays, show that cells from individuals maintained proliferative capacity, were not terminally differentiated (CD57−), more frequently...
HIV-2 infection in the majority of infected subjects follows an attenuated disease course that distinguishes it from with HIV-1. Antigen-specific T cells are pivotal management chronic viral infections but not sufficient to control replication HIV-1-positive subjects, and their function is fully established. In a community-based cohort long-term nonprogressors rural Guinea-Bissau, we performed what believe first comprehensive analysis HIV-2-specific immune responses. We demonstrate Gag most...
Extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) are sporadically reported from infections in sub-Saharan Africa. Travellers returning the tropics have a high risk of ESBL-E colonization, which suggests prevalence Our objective was to assess burden rectal colonization and associated factors Gabon, Central Africa We performed cross-sectional study on 200 hospitalized children Africa, applied standardized questionnaire factors. The antimicrobial resistance type β-lactamase...
Staphylococcus aureus is a bacterium that colonizes and infects both humans animals. As little known about the phenotypic molecular characteristics of S. from wild animals in sub-Saharan Africa, objective study was to characterize isolates wildlife analyse if they differed those found among humans. The resistance penicillin low non-human primates (2.9%). Phylogenetic analysis based on concatenated sequences multilocus sequence typing revealed two highly divergent groups isolates. One group...
The prevalence of HIV/hepatitis co-infection in sub-Saharan Africa is not well documented, while both HIV and HBV are endemic this area.The aim study to determine the seroprevalence HCV virus HIV-infected subjects Gambia.Plasma samples from infected patients (190 individuals with clinically defined AIDS 382 without AIDS) were tested retrospectively for presence sero-markers serum DNA, screened infection by testing anti-HCV antibody RNA.HBsAg HIV-positive 12.2%. HIV/HBV co-infected CD4 count...
ABSTRACT Drug design, antiretroviral therapy (ART), and drug resistance studies have focused almost exclusively on human immunodeficiency virus type 1 (HIV-1), resulting in limited information for patients infected with HIV-2 those dually HIV-1 HIV-2. In this study, 20 patients, 12 8 HIV-2, all treated zidovudine (ZDV), lamivudine (3TC), lopinavir-ritonavir (LPV/r), were followed up longitudinally about 3 years. For 19/20 viral loads reduced to undetectable levels; the patient whose load...
Ceftaroline and ceftobiprole are new cephalosporins, which active against MRSA by inhibiting PBP2a. Recently, high rates of resistance to ceftaroline were reported from Ghana. The objective this study was assess in Africa describe potential missense mutations PBP2a.MRSA isolates derived Staphylococcus aureus colonization (n = 37) infection 23) collected Côte d'Ivoire 17), DR Congo 6), Gabon 21) Nigeria 16). MICs determined the broth microdilution method. mecA gene sequenced associated with...
ABSTRACT Staphylococcus aureus is a major bacterial pathogen causing variety of diseases ranging from wound infections to severe bacteremia or intoxications. Besides host factors, the course and severity disease also widely dependent on genotype bacterium. Whole-genome sequencing (WGS), followed by bioinformatic sequence analysis, currently most extensive genotyping method available. To identify clinically relevant staphylococcal virulence resistance genes in WGS data, we developed an silico...
Various hantaviruses have been discovered in unconventional hosts (shrews and bats) Africa. Up to now, it was unknown whether these viruses pose a threat for human health. In this study, using newly established serological assays, we demonstrated evidence of shrew-borne hantavirus infections humans from Côte d'Ivoire Gabon.
Abstract Background Africa is challenged by the emergence of antimicrobial resistance (AMR). In order to improve patient management and optimise approaches curb spread resistance, we examined knowledge perceptions AMR antibiotics prescription practices HCW (healthcare workers) in Lambaréné, Gabon. Methods We conducted a self-administered, questionnaire-based survey at regional referral hospital, medical research centre, peripheral health care facilities. The proportions correct responses...