A5031615953- Viral Infections and Vectors
- Vector-borne infectious diseases
- Fire effects on ecosystems
- Vector-Borne Animal Diseases
- Mosquito-borne diseases and control
- Viral Infections and Outbreaks Research
- Yersinia bacterium, plague, ectoparasites research
- Poxvirus research and outbreaks
- Zoonotic diseases and public health
- Herpesvirus Infections and Treatments
- Animal Virus Infections Studies
- Virus-based gene therapy research
- Bacillus and Francisella bacterial research
- Animal Disease Management and Epidemiology
- Aquaculture disease management and microbiota
- Leptospirosis research and findings
- Viral gastroenteritis research and epidemiology
- Plant Virus Research Studies
- Insect and Pesticide Research
- Animal Ecology and Behavior Studies
- Disaster Response and Management
- Hepatitis B Virus Studies
- SARS-CoV-2 and COVID-19 Research
- Rabies epidemiology and control
- Insect symbiosis and bacterial influences
German Center for Infection Research
2016-2023
Institut für Mikrobiologie der Bundeswehr
2013-2022
Universität der Bundeswehr München
2011-2022
Bundeswehr Medical Service Academy
2011-2022
Slovak Academy of Sciences
2012
Charité - Universitätsmedizin Berlin
2012
Vivantes Klinikum
2012
Baden-Wuerttemberg Cooperative State University
2012
Friedrich-Loeffler-Institut
2012
Czech Academy of Sciences, Institute of Microbiology
2006-2011
Hantavirus infections are reported from many countries in Europe and with highly variable annual case numbers. In 2010, more than 2,000 human cases were Germany, numbers above the baseline have also been registered other European countries. Depending on virus type characterised by mild to severe forms of haemorrhagic fever renal syndrome. The member laboratories Network for diagnostics Imported Viral Diseases present here an overview progression period 2005 2010. Further we provide update...
SARS-CoV-2 infection is accompanied by elevated liver enzymes, and patients with pre-existing conditions experience more severe disease. While it was known that infects human hepatocytes, our study determines the mechanism of infection, demonstrates viral replication spread, highlights direct hepatocyte damage. Viral readily detectable upon primary hepatocytes hepatoma cells ancestral SARS-CoV-2, Delta, Omicron variants. Hepatocytes express receptor ACE2 host cell protease TMPRSS2, knocking...
Rodents are important reservoirs for a large number of zoonotic pathogens. We examined the occurrence 11 viral, bacterial, and parasitic agents in rodent populations Austria, including three different hantaviruses, lymphocytic choriomeningitis virus, orthopox Leptospira spp., Borrelia Rickettsia Bartonella Coxiella burnetii, Toxoplasma gondii. In 2008, 110 rodents four species (40 Clethrionomys glareolus, 29 Apodemus flavicollis, 26 sylvaticus, 15 Microtus arvalis) were trapped at two rural...
Rodent herpesviruses such as murine cytomegalovirus (host, Mus musculus), rat Rattus norvegicus), and gammaherpesvirus 68 (hosts, Apodemus species) are important tools for the experimental study of human herpesvirus diseases. However, alphaherpesviruses, roseoloviruses, lymphocryptoviruses, well rhadinoviruses, that naturally infect musculus (house mouse) other Old World mice unknown. To identify hitherto-unknown rodent-associated herpesviruses, we captured M. musculus, R. norvegicus, 14...
To examine the host association of Tula virus (TULV), a hantavirus present in large parts Europe, we investigated total 791 rodents representing 469 Microtus arvalis and 322 agrestis animals from northeast, northwest, southeast Germany, including geographical regions with sympatric occurrence both vole species, for presence TULV infections. Based on serological investigation, reverse transcriptase PCR, subsequent sequence analysis partial small (S) medium (M) segments, herein show that is...
Tularemia re-emerged in Germany starting 2004 (with 39 human cases from to 2007) after over 40 years of only sporadic infections. The reasons for this rise case numbers are unknown as is the possible reservoir etiologic agent Francisella (F.) tularensis. No systematic study on situation F. tularensis has been published so far.We investigated three areas six ten months initial tularemia outbreaks presence among small mammals, ticks/fleas and water. investigations consisted animal...
To investigate 2,017 cases of hantavirus disease in Germany, we compared 38 new patient-derived Puumala virus RNA sequences identified 2010 with bank vole-derived small segment sequences. The epidemic process was driven by outbreaks 6 clades comprising strains human and vole origin. Each clade corresponded to a different outbreak region.
So far, data on the natural cycle of rickettsiae tick-borne spotted fever group (SFG) in Central Europe are barely available. Some studies showed occurrence different Rickettsia species their arthropod vectors, but it is unclear which animals might have any kind reservoir function. This survey was therefore set up to provide information SFG small mammals Germany. A total 124 rodents and insectivores were collected over a period 3 years Lower Bavaria, South-Eastern Screening for antibodies...
Omsk haemorrhagic fever virus (OHFV) is the agent leading to (OHF), a viral disease currently only known in Western Siberia Russia. The symptoms include fever, headache, nausea, muscle pain, cough and haemorrhages. transmission cycle of OHFV complex. Tick bites or contact with infected small mammals are main source infection. Republic Kazakhstan adjacent endemic areas Russia febrile diseases haemorrhages occur throughout country—often unclear aetiology. In this study, we examined human...
A micro-epidemic of hantavirus infections occurred in Lower Bavaria, South-East Germany, starting April 2004. While only three cases were registered from 2001 to 2003, a dramatically increased number clinically apparent human (n=38) was observed 2004, plus seven additional by June 2005. To determine the reservoir responsible for infections, total 43 rodents trapped Bavaria. Serological and genetic investigations revealed that Puumala virus (PUUV) is dominant local population bank voles....
Recent reports of novel hantaviruses in shrews and moles the detection rodent-borne different rodent species raise important questions about their host range specificity, evolution, adaptation. Tula virus (TULV), a European hantavirus, is believed to be slightly or non-pathogenic humans was initially detected common vole Microtus arvalis, East M. levis (formerly rossiaemeridionalis), subsequently other species. Here we report first multiple RT-PCR sequence analyses TULV Eurasian water...
In Europe, hantaviruses (Bunyaviridae) are small mammal-associated zoonotic and emerging pathogens that can cause hemorrhagic fever with renal syndrome (HFRS). Puumala virus, the main etiological agent carried by bank vole Myodes glareolus is responsible for a mild form of HFRS while Dobrava virus induces less frequent but more severe cases HFRS. Since 2000 in than 3000 have been recorded, average, each year, which nearly double compared to previous decade. addition this upside long-term...
Abstract Many viruses significantly impact human and animal health. Understanding the population dynamics of these their hosts can provide important insights for epidemiology virus evolution. Puumala ( PUUV ) is a European hantavirus that may cause regional outbreaks hemorrhagic fever with renal syndrome in humans. Here, we analyzed spatiotemporal circulating local populations its rodent reservoir host, bank vole Myodes glareolus during eight years. Phylogenetic genetic analyses all three...
Small mammals serve as most important reservoirs for Leptospira spp., the causative agents of Leptospirosis, which is one neglected and widespread zoonotic diseases worldwide. The knowledge about spp. occurring in small from Germany scarce. Thus, this study's objectives were to investigate occurrence inherent sequence types three different study sites: a forest southern (site B1); National Park south-eastern B2) renaturalised area, eastern S) where captured. DNA was extracted kidneys tested...
The Norway rat Rattus norvegicus is an important reservoir of various zoonotic pathogens, such as cowpox virus and Leptospira, but also for agents no or unknown potential. We describe a survey 426 rats originating from five European countries different habitats Leptospira spp., rickettsiae, orthopoxvirus (OPV), avian metapneumovirus subtypes A B (aMPV) polyomavirus (rat PyV).Leptospira DNA was detected in 60 out 420 (14.3%) rats, Rickettsia found three 369 (0.8%) investigated. PCR-based...
Various hantaviruses have been discovered in unconventional hosts (shrews and bats) Africa. Up to now, it was unknown whether these viruses pose a threat for human health. In this study, using newly established serological assays, we demonstrated evidence of shrew-borne hantavirus infections humans from Côte d'Ivoire Gabon.
Parvoviruses were isolated from Python regius and Boa constrictor snakes propagated in viper heart (VH-2) iguana (IgH-2) cells. The full-length genome of a snake parvovirus was cloned both strands sequenced. organization the 4432-nt-long found to be typical parvoviruses. This flanked by inverted terminal repeats (ITRs) 154 nt, containing 122 nt hairpins contained two large open reading frames, encoding non-structural structural proteins. Genes this new most similar those waterfowl...