A5111540076- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Immunodeficiency and Autoimmune Disorders
- Eosinophilic Esophagitis
- Drug-Induced Adverse Reactions
- Contact Dermatitis and Allergies
- Urticaria and Related Conditions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Pediatric health and respiratory diseases
- Immune Cell Function and Interaction
- Respiratory and Cough-Related Research
- Infant Health and Development
- T-cell and B-cell Immunology
- Blood disorders and treatments
- Autoimmune Bullous Skin Diseases
- IL-33, ST2, and ILC Pathways
- Neonatal Respiratory Health Research
- Hemophilia Treatment and Research
- Cystic Fibrosis Research Advances
- Respiratory viral infections research
- Adolescent and Pediatric Healthcare
- Platelet Disorders and Treatments
- Immune Response and Inflammation
- Mast cells and histamine
Montreal Children's Hospital
2012-2025
McGill University Health Centre
2016-2025
McGill University
2012-2024
Christie (Canada)
2005-2011
Hospital of the University of Pennsylvania
2010
National Institute of Allergy and Infectious Diseases
2005-2006
Université de Montréal
2005
McMaster University
1988-1991
Wellesley Institute
1991
Human recombination-activating gene (RAG) deficiency can manifest with distinct clinical and immunological phenotypes. By applying a multiomics approach to large group of RAG-mutated patients, we aimed at characterizing the immunopathology associated each phenotype. Although defective T B cell development is common all phenotypes, patients hypomorphic RAG variants generate cells signatures immune dysregulation produce autoantibodies broad range self-antigens, including type I interferons....
Primary immunodeficiency disorder (PID) refers to a heterogeneous group of over 130 disorders that result from defects in immune system development and/or function. PIDs are broadly classified as adaptive immunity (i.e., T-cell, B-cell or combined immunodeficiencies) innate (e.g., phagocyte and complement disorders). Although the clinical manifestations highly variable, most involve at least an increased susceptibility infection. Early diagnosis treatment imperative for preventing...
Gain-of-function (GOF) mutations in the signal transducer and activator of transcription 1 (STAT1) result unbalanced STAT signaling cause immune dysregulation immunodeficiency. The latter is often characterized by susceptibility to recurrent Candida infections, resulting clinical picture chronic mucocutaneous candidiasis (CMC). This study aims assess frequency GOF STAT1 a large international cohort CMC patients. was sequenced genomic DNA from 57 patients 35 healthy family members. functional...
Hereditary angioedema (HAE) is a disease which associated with random and often unpredictable attacks of painful swelling typically affecting the extremities, bowel mucosa, genitals, face upper airway. Attacks are significant functional impairment, decreased Health Related Quality Life, mortality in case laryngeal attacks. Caring for patients HAE can be challenging due to complexity this disease. The care Canada neither optimal nor uniform across country. It lags behind other countries where...
Abstract Allergic airways disease is initiated and perpetuated by an aberrant Th2 inflammatory response regulated in part the cytokines IL-4 IL-13, each of which induces activation STAT-6 transcription factor. Data from murine models indicate that clinical manifestations acute asthma are dependent, thus, a target for drug development allergic disease. We designed novel chimeric peptide (STAT-6 inhibitory (STAT-6-IP)) comprised sequence predicted to bind inhibit STAT-6, fused protein...
<b><i>Background:</i></b> While a central role for the T helper (Th) 1/Th2 axis in food allergy has been established, Th17 response food-allergic humans not addressed. <b><i>Methods:</i></b> responses 18 peanut-allergic children, who were also allergic to at least one additional allergen, assessed relative 15 age-matched healthy controls. To account atopy background 7 atopic, but food-allergic, individuals and their controls included this...
ACADEMIC EMERGENCY MEDICINE 2011; 18:102–104 © 2011 by the Society for Academic Emergency Medicine Objectives: Medication error prevention has become a priority in health care. The Joint Commission recommends that list of medications, dosages, and allergies be obtained from all patients. authors sought to determine accuracy medication history taking emergency department (ED) triage. hypothesis was there would significant discrepancies between medications listed triage those patient actually...
Anaphylaxis is an acute systemic and potentially fatal allergic reaction. We evaluated trends in yearly rates of anaphylaxis a pediatric Emergency Department (ED) Montreal, Canada.A prospective retrospective recruitment process was used to find families children who had presented with at the Montreal Children's Hospital between April 2011 2021. Using uniform form, data were collected. patterns compared clinical triggers using descriptive analysis.Among 830,382 ED visits during study period,...