A5014374700- Hippo pathway signaling and YAP/TAZ
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Macrophage Migration Inhibitory Factor
- Axon Guidance and Neuronal Signaling
- CAR-T cell therapy research
- Nuclear Receptors and Signaling
- Zebrafish Biomedical Research Applications
Technion – Israel Institute of Technology
2014-2018
Rappaport Family Institute for Research in the Medical Sciences
2018
Adoptive transfer of Ag-specific T lymphocytes is an attractive form immunotherapy for cancers. However, acquiring sufficient numbers host-derived tumor-specific by selection and expansion challenging, as these cells may be rare or anergic. Using engineered can overcome this difficulty. Such generated using a chimeric Ag receptor based on common formats composed from Ag-recognition elements such αβ-TCR genes with the desired specificity, Ab variable domain fragments fused cell-signaling...
Abstract CD74, the cell-surface form of MHC class II invariant chain, is a key inflammatory factor that involved in various immune-mediated diseases as part macrophage migration inhibitory (MIF) binding complex. However, little known about natural regulators CD74 this context. In order to study role HLA-DR molecule regulating we used HLA-DRα1 domain, which was shown bind and downregulate on CD11b+ monocytes. We found DRα1 directly inhibited MIF blocked its downstream effects spinal cord mice...
Class-3 semaphorin guidance factors bind to receptor complexes containing neuropilin and plexin receptors. A may several somewhat different constituents, resulting in diverse effects on cell migration. U87MG glioblastoma cells express both neuropilins the four class-A plexins. Here, we show that these respond Sema3A or Sema3B by cytoskeletal collapse contraction but fail contract response Sema3C, Sema3D, Sema3G Sema3E, even when plexins are overexpressed cells. In contrast, expression of...