A5046160546- Axon Guidance and Neuronal Signaling
- Angiogenesis and VEGF in Cancer
- Hippo pathway signaling and YAP/TAZ
- Pharmacogenetics and Drug Metabolism
- Microbial Metabolic Engineering and Bioproduction
- Microbial metabolism and enzyme function
- Zebrafish Biomedical Research Applications
Technion – Israel Institute of Technology
2016-2022
Rappaport Family Institute for Research in the Medical Sciences
2018
Class-3 semaphorin guidance factors bind to receptor complexes containing neuropilin and plexin receptors. A may several somewhat different constituents, resulting in diverse effects on cell migration. U87MG glioblastoma cells express both neuropilins the four class-A plexins. Here, we show that these respond Sema3A or Sema3B by cytoskeletal collapse contraction but fail contract response Sema3C, Sema3D, Sema3G Sema3E, even when plexins are overexpressed cells. In contrast, expression of...
Previous studies revealed that progression of multiple myeloma (MM) is associated with downregulation semaphorin-3A (sema3A) expression in bone marrow endothelial cells. We therefore determined if serum sema3A concentrations are correlated MM and can affect progression. find the concentration sera patients strongly reduced decrease disease A similar depletion found having acute myeloid leukemia lymphoblastic but not cancer forms do involve such as colon cancer. Expression a modified...
The five lysyl-oxidase genes share similar enzymatic activities and contribute to tumor progression. We have knocked out the in MDA-MB-231 breast cancer cells using CRISPR/Cas9 order identify that are regulated by LOX but not other lysyl-oxidases study such more mechanistic detail future. Re-expression of full-length cDNA encoding identified four whose expression was downregulated knock-out rescued following re-expression lysyl-oxidases. These were AGR2, STOX2, DNAJB11 DNAJC3 genes. AGR2...