A5084589140- HIV Research and Treatment
- Immune Cell Function and Interaction
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- T-cell and B-cell Immunology
- Tuberculosis Research and Epidemiology
- Immune Response and Inflammation
- Mycobacterium research and diagnosis
- Immunotherapy and Immune Responses
- Hepatitis B Virus Studies
- Monoclonal and Polyclonal Antibodies Research
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Outbreaks Research
- Pneumocystis jirovecii pneumonia detection and treatment
- COVID-19 epidemiological studies
- Immunodeficiency and Autoimmune Disorders
- Reproductive System and Pregnancy
- vaccines and immunoinformatics approaches
- Cervical Cancer and HPV Research
- COVID-19 Clinical Research Studies
- HIV/AIDS Impact and Responses
- Immune responses and vaccinations
- Hepatitis C virus research
- Diagnosis and treatment of tuberculosis
- Immune cells in cancer
University of Rome Tor Vergata
2016-2025
Centre International De Reference Chantal Biya
2016-2025
University of Bamenda
2024
Université de Yaoundé I
2011-2024
Legacy Good Samaritan Medical Center
2024
Université Protestante d'Afrique Centrale
2024
Health Affairs
2022-2023
University of N'Djamena
2022-2023
University of Milan
2020
University of Ngaoundéré
2019
Traditional medicine refers to health practices, approaches, knowledge and beliefs incorporating plant, animal mineral based medicines, spiritual therapies, manual techniques exercises, applied singularly or in combination treat, diagnose prevent illnesses maintain well-being. In the last decade traditional has become very popular Cameroon, partly due long unsustainable economic situation country. The high cost of drugs increase drug resistance common diseases like malaria, bacteria...
Sida acuta is a shrub indigenous to pantropical regions. The plant widely used for its various pharmacological properties. Among compounds of interest occurring in the plant, are indoloquinoline alkaloids. aim present study was investigate antimicrobial activity alkaloids S. from Burkina Faso. had good against test microorganisms. In agar-well diffusion assay, highest inhibition zone diameters were recorded with Gram-positive bacteria. broth microdilution assay gave minimal inhibitory...
Background The vast majority of the population around world has always used medicinal plants as first source health care to fight infectious and non diseases. Most these may have scientific evidence be considered in general practice. Objective aim this work was investigate antioxidant capacities anti-inflammatory activities ethanol extracts leaves Cassia alata, Eleusine indica, Carica papaya, Eremomastax speciosa stem bark Polyscias fulva, collected Cameroon. Methods Chemiluminescence...
The types and methods of use antibiotics in poultry farms Cameroon, residual levels potential microbial resistance were determined. A questionnaire-based survey identified the different used high-performance liquid chromatography (HPLC) was to determine antibiotics. Pathogens isolated, by commercial API kits minimum inhibition concentration (MIC) Oxytetracyclin, tylocip TCN (oxytetracycline, chloramphenicol neomycin) most frequently Antibiotics screened HPLC chloramphenicol, tetracycline...
BackgroundThe frequency of asymptomatic infection with Ebola virus is unclear: previous estimates vary and there no standard test. Asymptomatic could contribute to population immunity, reducing spread. If people are infectious it explain re-emergences disease (EVD) without known contact.MethodsWe validated a new oral fluid anti-glycoprotein IgG capture assay among survivors from Kerry Town Treatment Centre controls communities unaffected by EVD in Sierra Leone. We then assessed the...
Objective Preliminary findings suggest a relationship between lower serum 25-hydroxyvitamin D [25(OH)D] levels and incidence severity of COVID-19. The aim this study was to evaluate the vitamin status at admission different markers inflammation, coagulation, sepsis in hospitalized patients with
Abstract Viral, bacterial, protozoal, and cancer-associated Ags elicit strong responses in human gammadelta T lymphocytes. The majority of these cells the peripheral blood express Vgamma9Vdelta2-encoded TCR recognize nonpeptidic phosphoantigens without an apparent MHC restriction. We have shown that Vgamma9Vdelta2 inhibitory CD94/NKG2 receptor for HLA class I molecules. anti-CD94 mAb inhibits 1) cell proliferation response mycobacterial 2) HIV-induced expansion. stimulated with antigens...
Tuberculosis (TB) is still a major health problem, both as single disease entity and cofactor in AIDS. The interaction between macrophage Mycobacterium tuberculosis (MTB) critical step the establishment of an early chronic infection. This study analyses capacity MTB to induce apoptosis cells obtained by broncho-alveolar lavage (BAL) from patients with reactive pulmonary AIDS disseminated tuberculosis. Apoptosis was increased three-fold BAL even more markedly alveolar macrophages MTB-infected...
Gamma delta T cells represent a minor population of human peripheral lymphocytes, the majority them expressing V 2/V gamma 9 TCR. Their accumulation in infectious disease lesions and their reactivity toward mycobacterial Ags suggest that 9/V 2 play role during diseases. We have shown previously significant expansion 1 subset parallel to dramatic decrease PBMC from HIV-infected persons. To understand mechanisms involved deletion cells, we analyzed ability respond vitro several t cell-specific...
Tuberculosis (TB) is still the principal cause of death caused by a single infectious agent, and balance between bacillus host defense mechanisms reflects different manifestations pathology. The aim this work was to study role myeloid-derived suppressor cells (MDSCs) during active pulmonary tuberculosis at site infection. We observed an expansion MDSCs in lung blood patients with TB, which are correlated enhanced amount nitric oxide plasma. also found that these have remarkable ability...
Abstract High-throughput technologies have produced a large amount of experimental and biomedical data creating an urgent need for comprehensive automated mining approaches. To meet this need, we developed SMAC (SMart Automatic Classification method): tool to extract, prioritise, integrate analyse molecular according user-defined terms. The robust ranking step performed on Medical Subject Headings (MeSH) ensures that papers are prioritised based specific user requirements. then retrieves any...
Abstract Human microvesicles are key mediators of cell–cell communication. Exosomes function as microRNA transporters, playing a crucial role in physiological and pathological processes. Plant (MVs) display similar features to mammalian exosomes, these MVs might enhance plant delivery mammals. Considering that microRNAs have been newly identified bioactive constituents medicinal plants, their potential regulators mammals has underlined, this study, we characterized purified from Moringa...
Introduction An increased incidence of human Monkeypox (Mpox) cases was recently observed worldwide, including in Cameroon. To ensure efficient preparedness and interventions the health system, we sought to assess knowledge Mpox's transmission, prevention, response among healthcare workers (HCWs) Methods A cross-sectional online survey conducted HCWs Cameroon using 21-item questions adapted from United States Centers for Disease Control Prevention (US-CDC) standard questionnaire on Mpox. The...
Abstract In humans, the circulating pool of mycobacteria-reactive Vγ9Vδ2+ T cells is expanded with age and may contribute to Mycobacterium tuberculosis immunosurveillance. We observed that two subsets could be identified on basis CD27 expression in immunocompetent adults, showing functionally differentiated γδ have lost expression. contrast, CD27−CD45RA−Vγ9Vδ2+ cell subset effector was absent cord blood from healthy newborns lacking peripheral HIV-infected patients. Moreover, effectors were...
Vγ9Vδ2 T lymphocytes are broadly reactive against various intracellular pathogens and display both lytic proliferative responses to human immunodeficiency virus (HIV)-infected cells. HIV infection of peripheral blood mononuclear cell cultures led absolute increases in cells accompanied by decreased p24 levels. Strong γδ activation with nonpeptidic mycobacterial phosphoantigens (TUBAg1 extract or synthetic isopentenyl pyrophosphate) resulted potent inhibition replication through soluble...
African ethnomedicine is essentially based on the traditional use of vegetal extracts. Since these natural drugs have shown health giving properties, in present study we increased further scientific basis supporting data. We investigated effects, murine B16F10 melanoma cells, plant extracts that were directly obtained by a Cameroon 'traditional healer'. After preliminary antioxidant functions compounds, already abundant literature, Moringa oleifera Lam., Eremomastax speciosa (Hochst.) Cufod...
Abstract Background After the launching of « Test & Treat » strategy and wider accessibility to viral load (VL), evaluating virological success (VS) would help in meeting UNAIDS targets by 2020 Cameroon. Setting methods Cross-sectional study conducted Chantal BIYA International Reference Centre for research on HIV/AIDS prevention management (CIRCB), Yaoundé, Cameroon; data generated between October 2016 August 2017 amongst adults, adolescents children at 12, 24, 36 ≥ 48 months ART. VS...
Moringa oleifera is a widespread plant with substantial nutritional and medicinal value. We postulated that microRNAs (miRNAs), which are endogenous, noncoding small RNAs regulating gene expression at the post-transcriptional level, might contribute to properties of plants this species after ingestion into human body, expression. However, knowledge scarce about miRNA in Moringa. Furthermore, order test hypothesis on pharmacological potential miRNA, we conducted high-throughput sequencing...
This study aimed to compare viral suppression (VS) between children, adolescents, and adults in the frame of transition dolutegravir (DTG)-based antiretroviral therapy (ART) Cameroonian context. A comparative cross-sectional was conducted from January 2021 through May 2022 amongst ART-experienced patients received at Chantal BIYA International Reference Centre Yaounde-Cameroon, for load (VL) monitoring. VS defined as VL < 1000 copies/mL undetectability 50 copies/mL. Chi-square multivariate...