A5057795207- Pain Mechanisms and Treatments
- Nerve injury and regeneration
- Aldose Reductase and Taurine
- Neuropeptides and Animal Physiology
- Cardiac Arrhythmias and Treatments
- Biochemical effects in animals
- Atrial Fibrillation Management and Outcomes
- Botulinum Toxin and Related Neurological Disorders
- Cardiac pacing and defibrillation studies
- Neurological Disorders and Treatments
- Cardiac electrophysiology and arrhythmias
- Axon Guidance and Neuronal Signaling
- Nitric Oxide and Endothelin Effects
- Calpain Protease Function and Regulation
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Adipose Tissue and Metabolism
- Viral-associated cancers and disorders
- Adenosine and Purinergic Signaling
- Sex work and related issues
- HIV/AIDS Research and Interventions
- Neurogenesis and neuroplasticity mechanisms
- Biochemical Acid Research Studies
- Lymphoma Diagnosis and Treatment
- Signaling Pathways in Disease
Derriford Hospital
2010-2024
University Hospitals Plymouth NHS Trust
2012-2024
Diversified Technical Systems (United States)
2024
Plymouth Hospital
2012-2021
Bradford Teaching Hospitals NHS Foundation Trust
2021
Cambridge University Hospitals NHS Foundation Trust
2021
University of Plymouth
2018
Royal Bournemouth and Christchurch Hospitals NHS Foundation Trust
2017
Oxford University Hospitals NHS Trust
2013
John Radcliffe Hospital
2007-2013
The onset of diabetic neuropathy, a complication diabetes mellitus, has been linked to poor glycemic control. We tested the hypothesis that mitogen-activated protein kinases (MAPK) form transducers for damaging effects high glucose. In cultures adult rat sensory neurons, glucose activated JNK and p38 MAPK but did not result in cell damage. However, oxidative stress ERK MAPKs resulted cellular dorsal root ganglia streptozotocin-induced rats (a model type I diabetes), were at 8 wk duration,...
This study used streptozotocin (STZ; 50 mg/kg i.p.) diabetic rats and monitored weekly thermal mechanical nociceptive thresholds for 8 weeks diabetes. Rats developed hyperalgesia as soon 2 after STZ injection. Thermal threshold was not altered up to Four week-diabetic rat showed reduced sensitivity the antinociceptive effect of morphine (5-20 i.p.). Furthermore, a GABA(B) agonist, (+/-)baclofen, observed. A dose high 16 i.p. (+/-)baclofen necessary reverse 4 hyperalgesia, whereas in control...
OBJECTIVE The goal of this study was to characterize glycation adducts formed in both vivo extracellular matrix (ECM) proteins endoneurium from streptozotocin (STZ)-induced diabetic rats and vitro by laminin fibronectin with methylglyoxal glucose. We also investigated the impact advanced end product (AGE) residue content ECM on neurite outgrowth sensory neurons. RESEARCH DESIGN AND METHODS Glycation, oxidation, nitration extracted control STZ-induced rat sciatic nerve (3–24 weeks post-STZ)...
TeleCheck-AF is a multicentre international project initiated to maintain care delivery for patients with atrial fibrillation (AF) during COVID-19 through teleconsultations supported by an on-demand photoplethysmography-based heart rate and rhythm monitoring app (FibriCheck®). We describe the characteristics, inclusion rates, experiences from participating centres according infrastructure as well characteristics recruited patients.Three surveys exploring centre (n = 25), 23), patient 826)...
Mitochondrial dysfunction has been proposed as a mediator of neurodegeneration in diabetes complications. The aim this study was to determine whether deficits insulin-dependent neurotrophic support contributed depolarization the mitochondrial membrane sensory neurons streptozocin (STZ)-induced diabetic rats. Whole cell fluorescent video imaging using rhodamine 123 (R123) used monitor inner potential (Δψm). Treatment cultured dorsal root ganglia (DRG) from normal adult rats for up 1 day with...
Aberrant neurofilament phosphorylation occurs in many neurodegenerative diseases, and this study, two animal models of type 1 diabetes--the spontaneously diabetic BB rat the streptozocin-induced rat--have been used to determine whether such a phenomenon is involved etiology symmetrical sensory polyneuropathy commonly associated with diabetes. There was two- threefold (P < 0.05) elevation lumbar dorsal root ganglia (DRG) rats that localized perikarya medium large neurons using...
PURPOSE A phase II study was performed of single-agent liposomally entrapped doxorubicin ([LED] Doxil; Liposome Technology Inc, Menlo Park, CA) against locally advanced cutaneous/systemic AIDS-related Kaposi's sarcoma (KS). PATIENTS AND METHODS Thirty-four patients with KS were treated 20 mg/m2 LED every 3 weeks on an outpatient basis. The median age 39 years and the Karnofsky score 70. All had poor prognostic disease as judged by AIDS Clinical Trials Group (ACTG) criteria. Nineteen 34...
This investigation was designed to determine whether the aldose reductase inhibitor Sorbinil prevented development of or reversed defects nerve conduction and axonal transport in streptozotocin-diabetic rats. Untreated diabetes either 3 6 wk duration caused a fall sciatic motor velocity (MNCV) 6–9 m/s (P < 0.001) significantly reduced accumulation axonally transported choline acetyltransferase activity against 24-h crush. These functional were associated with sorbitol depletion...
This study examined the role of p38 mitogen-activated protein (MAP) kinase in transducing high glucose into deficits nerve conduction velocity (NCV) that are characteristic diabetic neuropathy. activation and NCV were measured streptozocin-induced rats treated with a inhibitor, an aldose reductase insulin. Dorsal root ganglia (DRG) from animals showed marked at 12 weeks diabetes. Insulin treatment for last 4 diabetes normalized activation. Furthermore, was completely prevented by weeks’...
1. Methods are presented for studying axonal transport mechanisms in preparations of constricted hypogastric nerve/inferior mesenteric ganglia maintained vitro periods up to 48 hr. Under these conditions the ultrastructure tissue is excellently preserved.2. The proximo-distal movement noradrenaline and storage vesicles non-myelinated axons inhibited by both colchicine (10 mug/ml.) vinblastine sulphate (1 whilst mitochondria appears be unaffected.3. Neither nor depletes accumulated...
BackgroundThe ganglionated plexuses (GPs) of the intrinsic cardiac autonomic system may play a role in atrial fibrillation (AF).ObjectiveWe hypothesized that ablating ectopy-triggering GPs (ET-GPs) prevents AF.MethodsGANGLIA-AF (ClinicalTrials.gov identifier NCT02487654) was prospective, randomized, controlled, 3-center trial. ET-GPs were mapped using high frequency stimulation, delivered within refractory period and ablated until nonfunctional. If triggered AF became incessant,...
<b>Trisha Greenhalgh and colleagues</b> explore why inaccurate narratives about the mode of transmission SARS-CoV-2 emerged early in pandemic shaped a flawed policy response, with tragic consequences
Objectives Xylazine is commonly mixed with illicit opioids in Philadelphia, and potential associations wound issues, infectious diseases, overdoses are of public health concern. We used data from the National HIV Behavioral Surveillance Survey among persons who inject drugs (PWIDs) Philadelphia to better identify individuals at risk inform patients clinicians about xylazine factors. Methods compared characteristics participants reported using those not past 12 months. Among use, we between...