A5024308447- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Drug-Induced Adverse Reactions
- Urticaria and Related Conditions
- Autoimmune Bullous Skin Diseases
- Asthma and respiratory diseases
- Contact Dermatitis and Allergies
- Mast cells and histamine
- Hemophilia Treatment and Research
- Allergic Rhinitis and Sensitization
- Vitamin K Research Studies
- Food Allergy and Anaphylaxis Research
- Pharmaceutical studies and practices
- Peptidase Inhibition and Analysis
- Inflammatory mediators and NSAID effects
- Eosinophilic Disorders and Syndromes
- Biomedical Text Mining and Ontologies
- Immunodeficiency and Autoimmune Disorders
- Drug-Induced Hepatotoxicity and Protection
- Pharmacovigilance and Adverse Drug Reactions
- Heparin-Induced Thrombocytopenia and Thrombosis
- Public health and occupational medicine
- Monoclonal and Polyclonal Antibodies Research
- Occupational exposure and asthma
- Advanced Text Analysis Techniques
- Indoor Air Quality and Microbial Exposure
Jagiellonian University
2015-2024
Wroclaw Medical University
2024
Oxfam
2022
John Wiley & Sons (United States)
2022
John Wiley & Sons (United Kingdom)
2022
Krakow Cardiovascular Research Institute
2020
Szpital Uniwersytecki w Krakowie
2020
Collegium Medicum in Bydgoszcz
2018
Nicolaus Copernicus University
2018
University Hospital of Bern
2013
Hereditary angioedema (HAE) is a rare and disabling disease for which early diagnosis effective therapy are critical. This revision update of the global WAO/EAACI guideline on management HAE provides up-to-date guidance HAE. For this guideline, an international panel experts reviewed existing evidence, developed 28 recommendations, established consensus by online DELPHI process. The goal these recommendations to help physicians their patients in making rational decisions with deficient C1...
Anaphylaxis, which is rare, has been reported after COVID-19 vaccination, but its management not standardized.Members of the European Network for Drug Allergy and Academy Clinical Immunology interested in drug allergy participated an online questionnaire on pre-vaccination screening allergic reactions to vaccines, literature was analysed.No death due anaphylaxis vaccines confirmed scientific literature. Potential allergens, polyethylene glycol (PEG), polysorbate tromethamine are excipients....
The human ortholog MRGPRX2 and the mice ortholog, Mrgprb2 are activated by basic secretagogues neurokinins. A number of commonly used small-molecule drugs (e.g., neuromuscular blocking agents, fluoroquinolones, vancomycin) have been recently shown to activate these receptors under in vitro experimental conditions, what results mast cell degranulation. above also known cause IgE-mediated anaphylactic reactions allergic patients. new findings on mechanisms drug-induced degranulation may modify...
Patients with Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) are often exposed simultaneously to a few potentially culprit drugs. However, both the standard lymphocyte transformation tests (LTT) proliferation as assay end-point well skin tests, if done, negative.As provocation considered too dangerous, there is an urgent need identify relevant drug in SJS/TEN and improve sensitivity of able causative drug.Fifteen patients ALDEN score ≥ 6 18 drug-exposed controls were...
Abstract Background In patients who require venom immunotherapy (VIT), there is a need to identify underlying mast cell (MC) disorders since these may affect the risk and severity of future sting reactions long‐term effectiveness VIT. Methods 1319 individuals with Hymenoptera allergy (HVA) needed VIT from referral centers in Slovenia, Austria, Croatia, Poland underwent examination for KIT p.D816V peripheral blood leukocytes (PBL) using highly sensitive PCR test tryptase genotyping by digital...
BACKGROUND: Patients with hereditary C1‐inhibitor deficiency have recurrent attacks of angioedema, preferably treated concentrate. A recombinant human (rHuC1INH) was developed, derived from milk transgenic rabbits. This study undertaken to investigate the effects rHuC1INH in treatment acute angioedema patients a deficiency. STUDY DESIGN AND METHODS: were (at dose 100 U/kg) within 8 hours after onset an attack. Time initiation relief and time minimal symptoms reported by both patient treating...
Severe cutaneous adverse drug reactions (SCARs) represent life-threatening medical conditions and an appropriate causative diagnosis of these is the highest importance. Existing in vivo diagnostic methods are risky or just contraindicated patients. Therefore, vitro tests take on greater significance. In this survey, studies assays SCARs were identified with a defined searching strategy strict eligibility criteria. Different particular clinical manifestations groups drugs compared respect to...
1. Asher MI, Montefort S, Bjorksten B, Lai CK, Strachan DP, Weiland SK, et al. Worldwide time trends in the prevalence of symptoms asthma, allergic rhinoconjunctivitis, and eczema childhood: ISAAC Phases One Three repeat multicountry cross-sectional surveys. Lancet 2006; 368: 733–743. CrossRef Google Scholar
Hereditary angioedema (HAE) caused by a deficiency in functional C1 esterase inhibitor (C1INH) is characterized recurrent episodes of cutaneous and/or mucosal/submucosal tissue swelling affecting multiple anatomic locations. Previous studies demonstrated efficacy recombinant human C1INH (rhC1INH) for acute HAE attacks.This study evaluated the and safety rhC1INH (50 IU/kg) treatment attacks an open-label extension study.Time to onset symptom relief time minimal symptoms were assessed using...
The genetic alteration underlying the great majority of primary angioedema with normal C1 inhibitor (nl-C1-INH-HAE) cases remains unknown. To search for variants associated nl-C1-INH-HAE, we genotyped 133 unrelated nl-C1-INH-HAE patients using a custom next-generation sequencing platform targeting 55 genes possibly involved in pathogenesis. Patients already diagnosed F12 alterations as well those histaminergic acquired were excluded. A variant pathogenicity curation strategy was followed,...
In about 5% of patients with hereditary angioedema due to C1-inhibitor deficiency (C1-INH-HAE) no mutation in the SERPING1 gene is detected. C1-INH-HAE cases coding region after conventional genotyping were examined for defects intronic or untranslated regions gene. Using a next-generation sequencing (NGS) platform targeting entire SERPING1, 14 unrelated detectable mutations sequenced. Detected variants global minor allele frequency lower than (0.002%), submitted silico analysis using ten...
Hereditary angioedema (HAE) is a rare genetic disease. It characterized by recurrent attacks of angioedema. Evidence to what extent it affects patient functioning limited in the pediatric population. We aimed determine clinical characteristics and management Polish children with HAE measure health-related quality life (HRQoL) these patients. This cross-sectional study was conducted among 21 patients their caregivers, as well respective controls randomly selected from general During routine...
Mast cells (MCs) are immune that reside in tissues; particularly the skin, and gastrointestinal respiratory tracts. In recent years, there has been considerable interest Mas-Related G Protein-Coupled Receptor X2 (MRGPRX2), which is present on surface of MCs can be targeted by multiple exogenous endogenous ligands. It potentially implicated non-IgE-mediated pseudoallergic reactions inflammatory conditions such as asthma or atopic dermatitis. this paper, we review natural products herbal...
INTROduCTION Drug hypersensitivity reactions (DHRs) represent a significant public health problem, 1 as they affect about 7% of the general population. 2 They have extremely heterogeneous manifestations with exanthemas being most common. 3DHRs usually require withdrawal culprit drug along changes in subsequent therapy.Drug causality assessment based on history DHR alone is not satisfactory.It may result unnecessary avoidance widely used drugs and limit therapeutic options to less effective...
Paracetamol is a popular and easily available drug which used world-wide as analgesic, antipyretic agent. Hypersensitivity reactions to this involve wide range of symptoms various importance for patient management. The EudraVigilance (EV) database serves system monitoring adverse events (AE) due intake. We retrospectively recorded AE reports "paracetamol" reported from 1 January 2007 October 2018 fulfilled the category "serious" in EV. For further analysis retrieved were selected according...
: Over-the-counter availability and a good safety profile make paracetamol one of the most common analgesics in developed countries but also leading cause liver failure due to overdose. The objectives study were identify modifiable risk factors for severe hepatotoxicity following overdose adults.