A5051157407- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Tuberculosis Research and Epidemiology
- Respiratory and Cough-Related Research
- Inhalation and Respiratory Drug Delivery
- Respiratory Support and Mechanisms
- Allergic Rhinitis and Sensitization
- Heat shock proteins research
- Pulmonary Hypertension Research and Treatments
- Inflammatory Biomarkers in Disease Prognosis
- Airway Management and Intubation Techniques
- Childhood Cancer Survivors' Quality of Life
- Genomics, phytochemicals, and oxidative stress
- Glutathione Transferases and Polymorphisms
- Immune Response and Inflammation
- Mycobacterium research and diagnosis
- Pediatric health and respiratory diseases
- Neonatal Respiratory Health Research
- Tracheal and airway disorders
- Pharmacological Effects and Assays
- Liver Disease Diagnosis and Treatment
- Air Quality and Health Impacts
- Inflammasome and immune disorders
- Human Health and Disease
- Food Allergy and Anaphylaxis Research
University Hospital Centre Zagreb
2016-2025
University of Zagreb
2013-2024
Opća bolnica Karlovac
1992-2022
Institute of Pharmacology and Toxicology of the National Academy of Medical Sciences of Ukraine
2020
University of Dubrovnik
1991
Abstract Background In patients who require venom immunotherapy (VIT), there is a need to identify underlying mast cell (MC) disorders since these may affect the risk and severity of future sting reactions long‐term effectiveness VIT. Methods 1319 individuals with Hymenoptera allergy (HVA) needed VIT from referral centers in Slovenia, Austria, Croatia, Poland underwent examination for KIT p.D816V peripheral blood leukocytes (PBL) using highly sensitive PCR test tryptase genotyping by digital...
Chronic obstructive pulmonary disease (COPD), an increasing global health problem, may be complicated by acute atherothrombotic events. Although systemic inflammation plays the leading role in processes, platelet activation and increased coagulation together with oxidative stress can significantly exacerbate atherosclerosis COPD patients. In this study we determined count, mean volume (MPV) classical markers of – serum C-reactive protein (CRP), white blood cell (WBC) count relative...
Chronic obstructive pulmonary disease (COPD) is a complex inflammatory condition that can affect haemostasis. This study aimed to determine differences in platelet-related parameters between controls and COPD subjects. The hypothesis was platelet indices are disturbed patients, this would be accompanied by increased C-reactive protein (CRP), fibrinogen (Fbg) white blood cells (WBC). Therefore, count (Plt), – mean volume (MPV), distribution width (PDW), plateletcrit (Pct), their ratios...
Nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation plays an important role in chronic obstructive pulmonary disease (COPD) pathogenesis and might be involved ongoing inflammation. This study aimed to determine interleukin-1beta (IL-1β) plasma concentration as well IL1B, NLRP3 caspase-1 (CASP1) gene expression the Croatian COPD patients. 109 patients with stable age- sex-matched 95 controls were included study. Plasma IL-1β...
Aim- To compare the effectiveness of different biologic medications for treatment severe asthma. We retrospectively collected data on 74 patients treated with one four biologics (omalizumab, mepolizumab, reslizumab, or benralizumab) at Jordanovac Clinic Pulmonary Diseases, Zagreb, Croatia least two years. The were compared in terms number exacerbations, dose oral corticosteroids (OCS), asthma control test (ACT), forced expiratory volume 1 second (FEV1), vital capacity, fraction exhaled...
Heat-shock protein 70 (Hsp70) acts as a damage-associated molecular pattern (DAMP) in extracellular compartment and might induce secretion of pro-inflammatory cytokines trigger innate immunity. The aim the study was to assess whether its concentration is increased plasma patients with stable chronic obstructive pulmonary disease (COPD) explore association smoking status, severity airflow obstruction, symptoms exacerbations history. Blood samples were collected from 137 COPD 95 healthy...
Chronic obstructive pulmonary disease (COPD) is a complex and heterogeneous disease, with oxidative stress inflammation implicated in its development. Uric acid (UA) could exert anti-oxidative, pro-oxidative or pro-inflammatory effects, depending on the specific context. It was recently shown that soluble UA, not just crystals, activate nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome, leading to interleukin (IL)-1β secretion. We...
Introduction Treatment with biologics for severe asthma is informed by international and national guidelines defined regulating bodies, but how these drugs are used in real-life unknown. Materials methods The European Respiratory Society (ERS) SHARP Clinical Research Collaboration conducted a three-step survey collecting information on use Europe. Five geographically distant countries the questions, focusing seven end-points: availability financial issues, prescription administration...
An objective of the Severe Heterogeneous Asthma Registry, Patient-centered (SHARP) is to produce real-world evidence on a pan-European scale by linking nonstandardised, patient-level registry data. Mepolizumab has shown clinical efficacy in randomised controlled trials and prospective studies could therefore serve as proof principle for this novel approach. The aim present study was harmonise data from 10 national severe asthma registries characterise patients receiving mepolizumab, assess...
Chronic obstructive pulmonary disease (COPD) is a chronic characterized by progressive decline in lung function due to airflow limitation, mainly related IL-1β-induced inflammation. We have hypothesized that single nucleotide polymorphisms (SNPs) NLRP genes, coding for key regulators of IL-1β, are associated with pathogenesis and clinical phenotypes COPD. recruited 704 COPD individuals 1238 healthy controls this study. Twenty non-synonymous SNPs 10 different genes were genotyped. Genetic...
Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation and oxidant/antioxidant imbalance. Glutathione the most abundant cellular low-molecular weight thiol glutathione redox cycle fundamental component of antioxidant defence system. Concentration total catalytic activities peroxidase reductase were determined in peripheral blood patients (n = 109) healthy subjects 51). was not changed comparison to controls. However, we found statistically significant...
The use of anti-interleukin-5 (IL5) for severe asthma is based on criteria from randomised controlled trials (RCTs), but in real-life patients might not fulfil the eligibility may benefit biologics. We aimed to characterise starting anti-IL5(R) Europe and evaluate discrepancies between initiation real life RCTs.We performed a cross-sectional analysis with data at start Severe Heterogeneous Asthma Research collaboration Patient-centred (SHARP Central) registry. compared baseline...
Abstract Extracellular adenosine triphosphate (eATP)-driven inflammation was observed in chronic obstructive pulmonary disease (COPD) but not investigated patients’ blood. Therefore, this study aimed to investigate eATP concentration plasma of COPD patients and its association with severity smoking. Study included 137 stable 95 control subjects. determined EDTA by luminometric method, mRNA expression receptors P2X7R P2Y2R analysed quantitative polymerase chain reaction (qPCR). increased...
Background/Aims: Species-level identification of nontuberculous mycobacteria (NTM) is important in making decisions about the necessity and choice antimicrobial treatment. The reason predictable clinical significance susceptibility profile specific NTM species. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) recognized as a diagnostic tool for routine bacteria yeasts laboratory based on protein fingerprint analysis. aim study was to evaluate...
The complex role of the serotonin system in respiratory function and inflammatory diseases such as asthma is unclear. Our study investigated platelet (5-HT) levels monoamine oxidase B (MAO-B) activity, well associations with HTR2A (rs6314; rs6313), HTR2C (rs3813929; rs518147), MAOB (rs1799836; rs6651806) gene polymorphisms 120 healthy individuals patients different severity phenotypes. Platelet 5-HT concentration was significantly lower, while MAO-B activity considerably higher patients;...