A5020144605- Antibiotic Resistance in Bacteria
- Bacterial biofilms and quorum sensing
- Pharmaceutical and Antibiotic Environmental Impacts
- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Use and Resistance
- Pneumonia and Respiratory Infections
- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- Vibrio bacteria research studies
- Enterobacteriaceae and Cronobacter Research
- Mycobacterium research and diagnosis
- Urinary Tract Infections Management
- Tuberculosis Research and Epidemiology
- Infections and bacterial resistance
- Nosocomial Infections in ICU
- Brucella: diagnosis, epidemiology, treatment
- Medical and Biological Ozone Research
- Respiratory viral infections research
- Microbial infections and disease research
- Molecular Biology Techniques and Applications
- Streptococcal Infections and Treatments
- Infective Endocarditis Diagnosis and Management
- Infection Control in Healthcare
- Oral microbiology and periodontitis research
- Frailty in Older Adults
University Hospital Centre Zagreb
2013-2024
University of Zagreb
2012-2024
Klinički Bolnički Centar Rijeka
1964-2024
Abstract Introduction Although most patients recover within several weeks after acute COVID‐19, some of them develop long‐lasting clinical symptoms. Renal transplant recipients have an increased mortality risk from COVID‐19. We aimed to describe complications occurring COVID‐19 in this group patients. Methods A prospective single‐center cohort study was conducted at University Hospital Centre Zagreb. Patients with two negative reverse transcriptase‐polymerase chain reaction (RT‐PCR) tests...
One hundred sixty-nine nonreplicate imipenem-resistant Pseudomonas aeruginosa strains isolated in a large hospital on the coastal region of Croatia were studied. The most active antibiotics colistin and amikacin. Most isolates multiresistant. prevalent serotype was O12, followed by O11. Six carried bla(VIM-2) gene located novel class 1 integron composed its variable part bla(VIM-2)-bla(oxa-10)-ΔqacF-aacA4 genes. Metallo-β-lactamase-producing belonged to sequence types ST235 ST111.
The third most common healthcare-associated infection is surgical site (SSI), accounting for 14%-16% of infections. These SSIs are associated with high morbidity, numerous deaths, and greater cost.A prospective study was conducted to assess the incidence SSI in a single university hospital Croatia. We used Hospital Europe Link Infection Control through Surveillance (HELICS) protocol surveillance. were classified using standard definition National Nosocomial Infections (NNIS) system.The...
In February 2011, a 78-year-old male patient was admitted to Clinical Hospital Center Zagreb with subdural haematoma. Klebsiella pneumoniae reduced susceptibility carbapenems isolated. PCR revealed the presence of bla(KPC), bla(TEM), and bla(SHV) genes. Sequencing bla(KPC) gene identified K. carbapenemase (KPC)-2 beta-lactamase. The strain belonged ST37 clone by multilocus sequence typing. Infection control efforts limited spread KPC-producing in our hospital so far. To knowledge, this is...
This study was conducted to detect and analyse the presence of extended-spectrum β -lactamase (ESBL)-producing Klebsiella pneumoniae associated with a nosocomial outbreak at Croatian hospital. During 2007, 162 K. isolates reduced susceptibility third-generation cephalosporins were collected from various hospital units patient specimens. Most strains isolated urine (61 %), followed by blood cultures (13 wound swabs tracheal aspirates (5 intra-abdominal abscess (4 intravascular catheters (3 %)...
Zrinka Bošnjaka, Branka Bedenić*ab, Annarita Mazzariolc, Neda Jarža-Davilad, Sandra Šutod & Smilja Kalenićaba Department of Clinical and Molecular Microbiology, Hospital Centre Zagreb, Croatiab School Medicine, University Croatiac Faculty Medicine Surgery, Verona, Italyd Zagreb Institute Public Health "A. Štampar", Croatia
Background/Aims: Species-level identification of nontuberculous mycobacteria (NTM) is important in making decisions about the necessity and choice antimicrobial treatment. The reason predictable clinical significance susceptibility profile specific NTM species. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) recognized as a diagnostic tool for routine bacteria yeasts laboratory based on protein fingerprint analysis. aim study was to evaluate...
While smoking is recognized as one of the factors for development and progression periodontal diseases, a relation between composition subgingival microbiota yet to be elucidated. The aim this study was investigate prevalence bacteria in young smokers non-smokers without clinical signs disease. In cross-sectional study, performed at Department Pharmacology, School Dental Medicine, University Zagreb, we enrolled 32 periodontally healthy non-smokers, aged 25-35 years old. number oral...
Acinetobacter spp. is an opportunistic pathogen that has demonstrated increasing relevance in nosocomial infections. Carbapenem-resistant strains have been reported worldwide.Since 2014, screening for metallo-β-lactamases (MBLs) all isolates using phenotypic methods and PCR implemented at the University Hospital Center Zagreb.The bacterial strain was isolated from drain of a child hospitalized paediatric intensive care unit identified as guillouiae MALDI TOF automated system. The resistant...
Two Enterobacter hormaechei isolates harbouring three carbapenemase genes each, were isolated from two patients different ICUs at University Hospital Centre Zagreb, Croatia, which is to our knowledge, the first report of triple (blaVIM-2, blaNDM-1, and blaOXA-48) co-existence in E. hormachei strains also among Enterobacterales members Croatia. Antimicrobial susceptibility testing showed only colistin amikacin. The production carbapenemases was phenotypically tested by immunochromatographic...
<b><i>Background:</i></b> Methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) is a major global health care-associated pathogen. This study sought to examine the prevalence of MRSA in patients who were admitted vascular surgery ward during 3-month period. <b><i>Methods:</i></b> screening was accomplished through acquisition nasal, throat and perineal swabs. These swabs placed tryptic soy broth that had been supplemented with...
In order to further accelerate pathogen identification from positive blood cultures (BC), various sample preparation protocols identify bacteria with MALDI-TOF MS directly BCs have been developed. We evaluated an in-house method in comparison the Sepsityper® Kit (Bruker Daltonics, Bremen, Germany) as well benefit of on-plate formic acid extraction step following signal by BACTECTM FX system. Confirmation was achieved using subcultured growing biomass used for analysis. A total 113...
Kidney transplant recipient killer cell immunoglobulin‐like receptors (KIR) genotype and HLA‐C status of their donors have been separately associated with BK virus‐associated nephropathy (BKVAN) virus infection. Our aim was to determine whether different combinations recipients KIR genes donor ligands influence the risk BKVAN. Retrospective case‐control study included 23 BKVAN 46 persistently negative virus. Donor HLA‐C*07 positivity lower odds for BKVAN, bearing haplotype AA or lacking any...