A5057449227- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Inhalation and Respiratory Drug Delivery
- Scientific Computing and Data Management
- Allergic Rhinitis and Sensitization
- Pharmaceutical studies and practices
- Receptor Mechanisms and Signaling
- Cancer Genomics and Diagnostics
- IL-33, ST2, and ILC Pathways
- Immune Response and Inflammation
- Diet, Metabolism, and Disease
- Biomedical and Engineering Education
- Artificial Intelligence in Healthcare and Education
- Eicosanoids and Hypertension Pharmacology
- Genetics, Bioinformatics, and Biomedical Research
- Peroxisome Proliferator-Activated Receptors
- Genetics and Neurodevelopmental Disorders
- Fatty Acid Research and Health
- Delphi Technique in Research
- Advanced Chemical Sensor Technologies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiovascular Health and Risk Factors
- Bioinformatics and Genomic Networks
LifeTec Group (Netherlands)
2024-2025
University of Amsterdam
2018-2023
Amsterdam University Medical Centers
2019-2023
Amsterdam UMC Location University of Amsterdam
2018-2021
Utrecht University
2016-2020
Little is known about the characteristics and treatments of patients with severe asthma across Europe, but both are likely to vary. This first study in European Respiratory Society Severe Heterogeneous Asthma Research collaboration, Patient-centred (SHARP) Clinical Collaboration it designed explore these variations. Therefore, we aimed compare registries before starting biologicals. was a cross-sectional retrospective analysis aggregated data from 11 national that joined SHARP established...
Barrier dysfunction of airway epithelium contributes to the development allergies, hyper-responsiveness and immunological respiratory diseases. Short-chain fatty acids (SCFA) enhance restore barrier function intestinal epithelium. This study investigated whether acetate, propionate butyrate integrity bronchial epithelial cells. Differentiating human cells (16HBE) grown on transwells were exposed butyrate, acetate while trans-epithelial electrical resistance was monitored over time....
Precision, or personalised medicine has advanced requirements for medical data management systems (MedDMSs). MedDMS precision should be able to process hundreds of parameters from multiple sites, adaptable while remaining in sync at locations, real-time syncing analytics and compliant with international privacy legislation. This paper describes the LogiqSuite software solution, aimed support a solution patient care (LogiqCare), research (LogiqScience) science (LogiqAnalytics) level. is...
The use of anti-interleukin-5 (IL5) for severe asthma is based on criteria from randomised controlled trials (RCTs), but in real-life patients might not fulfil the eligibility may benefit biologics. We aimed to characterise starting anti-IL5(R) Europe and evaluate discrepancies between initiation real life RCTs.We performed a cross-sectional analysis with data at start Severe Heterogeneous Asthma Research collaboration Patient-centred (SHARP Central) registry. compared baseline...
<b>Introduction:</b> Little is known about the characteristics and treatments of severe asthmatics across Europe but both are likely to vary. The ERS Severe Heterogeneous Asthma Research collaboration, Patient-centred (SHARP) set up improve lives European asthma patients. <b>Aim:</b> To compare patients in registries before starting biologicals inform further registry development. <b>Methods:</b> Cross-sectional retrospective analysis aggregated data from 10 national that joined SHARP with...
Abstract Introduction Precision, or personalised medicine has advanced requirements for medical data management systems (MedDMSs). MedDMS precision should be able to process hundreds of parameters from multiple sites, adaptable while remaining in sync at locations, real-time syncing analytics and compliant with international privacy legislation. This paper describes the LogiqSuite software solution, aimed support a solution patient care (LogiqCare), research (LogiqScience) science...
<b>Background:</b> Clinical trials investigating mepolizumab for eosinophilic severe asthma patients employed strict eligibility criteria. Nonetheless, not meeting these criteria are treated with in clinical practice. <b>Aim:</b> To investigate the extent and reasons trial ineligibility of real-life, mepolizumab-treated patients. compare characteristics populations. <b>Methods:</b> Trial patient SIRIUS, DREAM MENSA were extracted. Baseline from mepolizumab-treated, oral...
<b>Rationale:</b> Analysis of exhaled volatile organic compounds (VOCs) by sensor-driven electronic nose (eNose) technology is a widely suggested measure for non-invasive monitoring chronic airway diseases. While this allows probabilistic (clinical) advise, it incapable providing details regarding involved metabolites. Modelling sensor deflections matching Gas Chromatography-Mass Spectrometry (GC-MS) samples could help to ascertain which VOCs induce response. <b>Objective:</b> To determine...