A5047068088- Blood groups and transfusion
- Erythrocyte Function and Pathophysiology
- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Multiple Myeloma Research and Treatments
- Platelet Disorders and Treatments
- Blood disorders and treatments
- Ion Channels and Receptors
- Neuroscience of respiration and sleep
- Neonatal Respiratory Health Research
- Smoking Behavior and Cessation
- Mast cells and histamine
- Hepatitis C virus research
- Blood donation and transfusion practices
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Nerve injury and regeneration
- Prenatal Substance Exposure Effects
- Epigenetics and DNA Methylation
- Hepatitis B Virus Studies
- Blood transfusion and management
Croatian Institute of Transfusion Medicine
2017-2024
Aim- To compare the effectiveness of different biologic medications for treatment severe asthma. We retrospectively collected data on 74 patients treated with one four biologics (omalizumab, mepolizumab, reslizumab, or benralizumab) at Jordanovac Clinic Pulmonary Diseases, Zagreb, Croatia least two years. The were compared in terms number exacerbations, dose oral corticosteroids (OCS), asthma control test (ACT), forced expiratory volume 1 second (FEV1), vital capacity, fraction exhaled...
Croatia implemented individual donation (ID)-NAT testing of blood donors in 2013 for three viruses HBV, HCV, and HIV-1 as a mandatory test all donors. This study assessed the impact NAT screening 3 years after its implementation.A total 545,463 donations were collected screened using Procleix Ultrio Plus Assay. All initially reactive (IR) samples retested triplicate and, if repeatedly (RR), discriminatory assay (dNAT) was performed. ID-NAT positive confirmed by RT-PCR on COBAS...
The complex role of the serotonin system in respiratory function and inflammatory diseases such as asthma is unclear. Our study investigated platelet (5-HT) levels monoamine oxidase B (MAO-B) activity, well associations with HTR2A (rs6314; rs6313), HTR2C (rs3813929; rs518147), MAOB (rs1799836; rs6651806) gene polymorphisms 120 healthy individuals patients different severity phenotypes. Platelet 5-HT concentration was significantly lower, while MAO-B activity considerably higher patients;...
Brain-derived neurotrophic factor (BDNF) and its tropomyosin-related kinase B (TrkB) receptor might contribute to normal lung functioning immune responses; however, their role in asthma remains unclear. Plasma BDNF concentrations, as well NTRK2 (TrkB gene) polymorphisms, were investigated 120 patients healthy individuals using enzyme-linked immunosorbent assay polymerase chain reaction, respectively. The genotype allele frequencies of Val66Met (rs6265) rs1439050 polymorphisms did not differ...
The aim of this study was to determine RHESUS D GENE (RHD) allelic variants among Croatian D-negative blood donors and compare our results with respective data from other European countries.Altered or reduced antigen expression can result in variants, which be mistyped lead the alloimmunisation recipient. RHD genotyping distinguish variants: weak D, partial DEL, thus preventing alloimmunisation.A total 6523 samples obtained were screened for presence using real-time polymerase chain reaction...
Abstract Introduction Exposure to normal or variably expressed RhD antigens in an antigen‐negative individual can elicit immune response and lead the formation of clinically significant anti‐D alloantibodies. We present case alloimmunization by DEL variant missed routine blood donor screening. Material Methods Blood donors were typed for D antigen using direct serologic micromethod. Nonreactive samples confirmed indirect antiglobulin method with IgM/IgG monoclonal reagent. Genomic DNA was...
Existence of hundreds RHD gene variants contributes to variable D antigen expression and inconsistencies in reporting the results. The aim study was determine serological molecular characteristics most prevalent alleles encoding serologically weak variants.Blood donors (n = 145 924) were typed for using direct serologic micromethod. Nonreactive samples analysed IAT method with IgM/IgG anti-D monoclonal blend, 0,2% 263) confirmed expression. After genomic DNA extraction (Qiaqen, Germany),...
<p><strong>Aim <br /></strong>ABO blood group genotypes are established as a genetic factor in pathophysiology of various diseases, such cardiovascular disorders, cancers, infectious diseases and there is rising evidence their involvement other conditions. The aim this study was to determine if ventilatory changes lung function asthma, measured by biomarkers/parameters, connected certain ABO Croatia....