A5014264319- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Respiratory and Cough-Related Research
- Inhalation and Respiratory Drug Delivery
- Pediatric health and respiratory diseases
- Urticaria and Related Conditions
- Food Allergy and Anaphylaxis Research
- Dermatology and Skin Diseases
- Olfactory and Sensory Function Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Eosinophilic Esophagitis
- Cancer Research and Treatments
- Human Health and Disease
- IL-33, ST2, and ILC Pathways
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Healthcare Systems and Public Health
- Advanced Materials Characterization Techniques
- Advancements in Photolithography Techniques
- Electron and X-Ray Spectroscopy Techniques
- SARS-CoV-2 and COVID-19 Research
- Synthesis and Characterization of Heterocyclic Compounds
- Nasal Surgery and Airway Studies
- Mast cells and histamine
- Genomics and Phylogenetic Studies
- Medical and Biological Sciences
Russian Medical Academy of Continuous Professional Education
2016-2025
Ministry of Health of the Russian Federation
2016-2024
Universität Greifswald
2023-2024
Institute of Mathematics and Computer Science
2023
Ministry of Health
2019-2021
European Respiratory Society
2015
Russian Respiratory Society
2015
The Earth Biogenome Project has rapidly increased the number of available eukaryotic genomes, but most released genomes continue to lack annotation protein-coding genes. In addition, no transcriptome data is for some genomes.
The article provides a review on prevalence, phenotypes, endotypes, and the control of severe bronchial asthma. Severe asthma is widespread, heterogeneous disease that affects 5 – 20% patients with Prevalence in Russia significantly exceeds official statistics data, therefore it necessary to maintain national register conventional therapy for not always effective due uncontrolled course eosinophilic airway inflammation. identification phenotype/endotype reasonable develop personalized...
Bronchial asthma is a heterogeneous disease that requires identification of its phenotype and personalized approach to therapy. At the same time, despite wide range therapeutic options, many patients with cannot achieve control over disease. Methodology . The target audience these clinical recommendations are general practitioners, therapists, pediatricians, allergologists-immunologists, pulmonologists, functional diagnostics doctors. Each thesis-recommendation about diagnostic procedures...
BackgroundThe 2021 Global Initiative for Asthma (GINA) report recommends 2 treatment tracks depending on choice of reliever therapy: either inhaled corticosteroid (ICS)/formoterol, or short-acting β2-agonist (SABA) with ICS to be used whenever a SABA is taken.ObjectiveThe Patients' and Physicians' Perspectives the Burden Management (APPaRENT) study aimed understand current real-world approaches their alignment GINA recommendations.MethodsPatients physicians were recruited online survey from...
The Expert Council was devoted to the development of algorithm diagnostics and treatment anxiety disturbances in patients with somatic diseases general clinical practice. level clinicians from various medical fields took part creation algorithm, which allowed take into account different approaches opinions. is aimed at identifying a profile their timely treatment. Temgicoluril discussed as one recommended drugs for conditions outpatient
Immunoglobulin E is the last of discovered immunoglobulins, which main mediator allergic reactions. Its role in allergy pathogenesis led to creation biological drug for treatment diseases - omalizumab. Omalizumab binds free immunoglobulin E, preventing its binding high-affinity receptors, thereby blocking cascade inflammation. This review discusses results studies omalizumab severe bronchial asthma, chronic spontaneous urticaria and other diseases. Despite more than twenty years use drug,...
Bronchial asthma (AA) remains one of the most significant respiratory diseases in world and Russia. The number patients with AA is steadily increasing, disease control not achieved all patients, even adequate pharmacotherapy. only currently available method for treatment allergy that can influence natural course allergen-specific immunotherapy (AIT). Scientific communities are focused on promoting disease-modifying solutions based compelling clinical evidence order to rethink approaches...
Allergic rhinitis (AR) is a common chronic respiratory disease that affects millions of people worldwide and has significant impact on their quality life, productivity, performance. Achieving control symptoms moderate/severe AR, which often requires the use several drugs from different pharmacological groups, particularly challenging intranasal fixed combination (InFC) fluticasone propionate (FP) azelastine hydrochloride (AZE) (MP-AzeFlu) for treatment seasonal AR (SAR). The FP AZE...
Every third patient at a dermatologist’s appointment suffers from allergic dermatosis. Traditionally, in Russia this term includes diseases such as atopic dermatitis, contact eczema and urticaria. All are based on immune-mediated inflammation, accompanied by itching of varying degrees intensity. Itching can affect work productivity, sleep quality mood, aggravate skin lead to complications. The occurrence maintenance is caused mechanical irritation, direct with allergens, exposure chemical...
Аллергический ринит – широко распространенное заболевание, которое значительно ухудшает качество жизни пациентов. Авторы провели исследование эффективности терапии фиксированной комбинацией монтелукаста и левоцетиризина у взрослых пациентов с сезонным аллергическим ринитом в период цветения злаковых трав. В включены пациенты клинически значимой сенсибилизацией к тимофеевке и/или пыльце трав, испытывающие симптомы аллергического ринита средней тяжелой степени тяжести. Результаты показали, что...
Зуд – неприятное ощущение, при котором у человека возникает желание почесать определенный участок кожи. Он может быть вызван дерматологическими, системными (например, почечными, гепатобилиарными, эндокринными), паранеопластическими, невропатическими и психогенными причинами. Ввиду разнообразной этиологии кожный зуд представляет собой сложную задачу для клиницистов. Распространенность зуда в популяции высока, однако некоторые группы населения подвержены повышенному риску его возникновения,...
Introduction Treatment with biologics for severe asthma is informed by international and national guidelines defined regulating bodies, but how these drugs are used in real-life unknown. Materials methods The European Respiratory Society (ERS) SHARP Clinical Research Collaboration conducted a three-step survey collecting information on use Europe. Five geographically distant countries the questions, focusing seven end-points: availability financial issues, prescription administration...
Bronchial asthma is a heterogeneous disease with variable course. Identification of pathobiological mechanisms phenotype, also called as endotypes, an urgent task to optimize treatment asthma, especially severe asthma. Although the author recognizes that T2-low serious problem, this article devoted T2-high endotype. Currently, biological agents are available for only, so focus on T2 high important. Current characteristics uncontrolled, difficult-to-treat and eosinophilic inflammation in main...
Atopic dermatitis is one of the most common diseases (20‒40% among skin diseases) that occur in both genders worldwide and different age groups. The problem urgency caused by an increase morbidity, a chronic relapsing course often leads to decrease quality life disability, low efficiency traditional treatment methods, limited access contemporary effective targeted therapy. clinical guidelines, which aimed optimize care for patients with atopic dermatitis, contain up-to-date information on...
Biological therapy of bronchial asthma (BA) is a modern method treating severe forms the disease, that are uncontrolled by traditional pharmacotherapeutic approaches. Currently, 5 monoclonal antibody (AT) preparations registered in world for treatment (SBA) T2 endotype (T2-SBA) – antibodies, binding to immunoglobulin (Ig) E (anti-IgE omalizumab), interleukin antagonists (IL)-5 (anti-IL-5 mepolizumab, resizumab) and its receptor (anti-IL-5Rα benralizumab), as well selectively bind IL-4 -13...
<b><i>Introduction:</i></b> Allergic rhinitis (AR) is a disease that affects ≤24% of people in Russia, significantly impairing quality life (QoL). Intranasal corticosteroids, such as triamcinolone acetonide (TAA), are considered effective drugs for treatment. A post hoc analysis data (phase III NASANIF trial) examined weekly QoL changes patients receiving TAA the treatment perennial AR (PAR). <b><i>Methods:</i></b> (NCT03317015) was...
Background The coronavirus disease 2019 (COVID-19) pandemic has put pressure on healthcare services, forcing the reorganisation of traditional care pathways. We investigated how physicians taking severe asthma patients in Europe reorganised care, and these changes affected patient satisfaction, control future care. Methods In this European-wide cross-sectional study, surveys were sent to with a physician-diagnosis asthma, physician specialists between November 2020 May 2021. Results 1101 268...
Asthma and chronic obstructive pulmonary disease remain major problems of medicine, still there is need to improve the level quality diagnosis these diseases. Primary care physicians (general practitioners, therapists) should be involved widely actively in this process. To simplify diagnosis, special questionnaires have been developed, they can used a real clinical practice. Only approach will bring statistical data closer true prevalence diseases their treatment.
Aim. Creation of the "Russian register patients with severe asthma" and obtaining data on population characteristics asthma (SA), prevalence SA phenotypes, treatment outcomes degree disease control. Materials methods. Observational non-interventional study, which consists in analysis obtained basis registration cards Russian Register Patients Severe Bronchial Asthma, collection was carried out Oracle XE platform. Statistical processing using Power BI, PSPP Microsoft Excel spreadsheets....
Aim. Effectiveness and safety of levosalbutamol metered dose inhaler (MDI) in comparison with placebo salbutamol. Materials methods. In this multicenter, randomized, placebo-controlled, 3-period crossover study, all asthma patients (n=91) received (90 mcg), salbutamol (180 using standard MDI. Pulmonary function testing – forced expiratory volume the first second (FEV1) vital capacity (FVC) was performed 45 15 minutes before 5, 10, 15, 30, 60, 90, 120, 180, 240, 300 360 after dosing. The...