Musa Khaitov
A5062099708- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
- Respiratory viral infections research
- RNA Interference and Gene Delivery
- IL-33, ST2, and ILC Pathways
- Dermatology and Skin Diseases
- Pediatric health and respiratory diseases
- SARS-CoV-2 and COVID-19 Research
- Advanced biosensing and bioanalysis techniques
- Fullerene Chemistry and Applications
- COVID-19 Clinical Research Studies
- Respiratory and Cough-Related Research
- Contact Dermatitis and Allergies
- Antimicrobial Peptides and Activities
- Immune Cell Function and Interaction
- Sinusitis and nasal conditions
- Immunodeficiency and Autoimmune Disorders
- Monoclonal and Polyclonal Antibodies Research
- Neonatal Respiratory Health Research
- Eosinophilic Esophagitis
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Immunotherapy and Immune Responses
- Virus-based gene therapy research
Federal Medical-Biological Agency
2016-2025
Pirogov Russian National Research Medical University
2021-2025
Institute of Immunology and Physiology
2015-2024
Ministry of Health of the Russian Federation
2023-2024
Institute of Immunology
2007-2024
Peoples' Friendship University of Russia
2023-2024
State Research Institute of Highly Pure Biopreparations
2024
Research Institute of Vaccines and Sera. Mechnikov of the Russian Academy of Medical Sciences
2023
Kharkiv Medical Academy of Postgraduate Education
2023
Charité - Universitätsmedizin Berlin
2021
Rhinoviruses are the major cause of asthma exacerbations; however, its underlying mechanisms poorly understood. We hypothesized that epithelial cell-derived cytokine IL-33 plays a central role in exacerbation pathogenesis through augmentation type 2 inflammation.To assess whether rhinovirus induces inflammatory response vivo and to define for this pathway.We used human experimental model infection novel airway sampling techniques measure IL-4, IL-5, IL-13, levels asthmatic healthy airways...
Respiratory viruses, predominantly rhinoviruses are the major cause of asthma exacerbations. Impaired production interferon-beta in rhinovirus infected bronchial epithelial cells (BECs) and newly discovered interferon-lambdas both BECs bronchoalveolar lavage cells, is implicated exacerbation pathogenesis. Thus replacement deficient interferon a candidate new therapy for Rhinoviruses other respiratory viruses infect macrophages, but their relative capacities alpha-, beta- lambda-interferon...
First vaccines for prevention of Coronavirus disease 2019 (COVID-19) are becoming available but there is a huge and unmet need specific forms treatment. In this study we aimed to evaluate the anti-SARS-CoV-2 effect siRNA both in vitro vivo.To identify most effective molecule out panel 15 silico designed siRNAs, an screening system based on vectors expressing SARS-CoV-2 genes fused with firefly luciferase reporter gene SARS-CoV-2-infected cells was used. The potent siRNA, siR-7, modified by...
To the Editor, A novel strain of human coronaviruses, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), named by International Committee on Taxonomy Viruses (ICTV),1 has recently emerged and caused an infectious disease. This disease is referred to as "coronavirus 2019" (COVID-19) World Health Organization (WHO).2 The US Centers for Disease Control Prevention (CDC) have proposed that "People with moderate asthma may be at higher risk getting very sick from COVID-19. COVID-19 can...
Although there are many asymptomatic patients, one of the problems COVID-19 is early recognition disease. symptoms polymorphic and may include upper respiratory symptoms. However, be mistaken with common cold or allergic rhinitis. An ARIA-EAACI study group attempted to differentiate between three diseases.A modified Delphi process was used. The ARIA members who were seeing patients asked fill in a questionnaire on airway COVID-19, rhinitis.Among 192 invited respond questionnaire, 89...
Water-soluble form of fullerene C60 is a promising tool for the control ROS-dependent inflammation including allergic diseases. Anti-inflammatory effects (nC60) aqueous dispersion were evaluated in mouse models atopic dermatitis using subcutaneous (SC) and epicutaneous (EC) applications during 50 days period. A highly stable nC60 was prepared by exhaustive dialysis water-organic solution against water, where size ζ-potential nanoparticles are about 100 nm −30 mV, respectively. To induce skin...
During the ongoing coronavirus disease 2019 (COVID-19) pandemic, many individuals were infected with and have cleared virus, developing virus-specific antibodies effector/memory T cells. An important unanswered question is what levels of T-cell antibody responses are sufficient to protect from infection.
Severe acute respiratory syndrome corona virus (SARS-CoV-2) infection frequently causes severe and prolonged disease but only few specific treatments are available. We aimed to investigate safety efficacy of a SARS-CoV-2-specific siRNA-peptide dendrimer formulation MIR 19® (siR-7-EM/KK-46) targeting conserved sequence in known SARS-CoV-2 variants for treatment COVID-19.We conducted an open-label, randomized, controlled multicenter phase II trial (NCT05184127) evaluating inhaled...