A5087038818- Immune Response and Inflammation
- Immune cells in cancer
- Immune Cell Function and Interaction
- COVID-19 Clinical Research Studies
- Neonatal Respiratory Health Research
- Immune responses and vaccinations
- COVID-19 epidemiological studies
- SARS-CoV-2 and COVID-19 Research
- Immunotherapy and Immune Responses
- Herpesvirus Infections and Treatments
- Cancer Cells and Metastasis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Multiple Sclerosis Research Studies
- Mathematical Biology Tumor Growth
- RNA modifications and cancer
- Cytomegalovirus and herpesvirus research
- Genomics and Chromatin Dynamics
- NF-κB Signaling Pathways
- Receptor Mechanisms and Signaling
- Cancer, Stress, Anesthesia, and Immune Response
- Sepsis Diagnosis and Treatment
- RNA Research and Splicing
- Veterinary medicine and infectious diseases
- Animal Disease Management and Epidemiology
- Chemokine receptors and signaling
Federal Medical-Biological Agency
2011-2022
Institute of Immunology and Physiology
2022
Institute of Immunology
2022
State Research Institute of Highly Pure Biopreparations
2022
During the ongoing coronavirus disease 2019 (COVID-19) pandemic, many individuals were infected with and have cleared virus, developing virus-specific antibodies effector/memory T cells. An important unanswered question is what levels of T-cell antibody responses are sufficient to protect from infection.
Upon activation with pathogen-associated molecular patterns, metabolism of macrophages and dendritic cells is shifted from oxidative phosphorylation to aerobic glycolysis, which considered important for proinflammatory cytokine production. Fragments bacterial peptidoglycan (muramyl peptides) activate innate immune through nucleotide-binding oligomerization domain (NOD) 1 and/or NOD2 receptors. Here, we show that NOD1 agonists induce early glycolytic reprogramming human monocyte-derived...
Glatiramer acetate (GA) is approved for the treatment of multiple sclerosis (MS). However, mechanism action GA in MS still unclear. In particular, it not known whether can modulate pro-inflammatory Th17-type immune response MS. We investigated effects original (Copaxone®, Teva, Israel) and generic (Timexone®, Biocad, Russia) on Th17- Th1-type cytokine production vitro 25 patients with relapsing-remitting healthy subjects. Both at concentrations 50–200 μg/ml dose-dependently inhibited...
Interactions between pattern-recognition receptors shape innate immune responses to pathogens. NOD1 and TLR4 are synergistically interacting playing a pivotal role in the recognition of Gram-negative bacteria. However, mechanisms their cooperation poorly understood. It is unclear whether synergy produced at level signaling pathways downstream or more distal levels such as gene transcription. We analyzed sequential stages human macrophage activation by combination agonists...
ABSTRACT NK cells lyse virus-infected by degranulation; however, alterations in cell degranulation persistent viral infections have not been directly studied. Earlier reports documented a decrease activity patients with frequently recurring herpes (FRH). We corroborate these findings showing that the responses of blood from FRH, both during relapse and remission, are significantly lower than those healthy donors. The impaired was probably caused defective target recognition, since it...
Summary Rapid spread of COVID-19 pandemic made a substantial share the world population immunised by SARS-CoV-2 antigens. Infection induces development virus-specific antibodies and T cells. Ample evidence on antibody-mediated protection is contrasted elusive role cells in preventing infection. To explore impact to quantify protective levels immune responses we conducted large prospective study: 5,340 Moscow residents were evaluated for antibody cellular monitored up 300 days. The tightly...
Сравнительная характеристика транскриптомов макрофагов человека, активированных агонистами рецепторов NOD1
Муругина Н.Е
Аэробный гликолиз не играет незаменимой роли в продукции провоспалительных цитокинов дендритными клетками 1 Федеральное государственное бюджетное учреждение «Государственный научный центр «Институт иммунологии» Федерального медико-биологического агентства, 115522, г.Москва, Российская Федерация 2 образовательное высшего образования «Московский государственный университет имени М.В.Ломоносова», 119991, 3 автономное Российский исследовательский медицинский им.Н.И.Пирогова Министерства...
Врожденный иммунитет
3D-модели злокачественных опухолей -современный подход к оценке противоопухолевых свойств макрофагов 1 Федеральное государственное бюджетное учреждение «Государственный научный центр «Институт иммунологии» Федерального медико-биологического агентства
We provide the fi rst characterization of glucose and energy metabolism rearrangements in human macrophages upon their activation with a NOD1 receptor agonist (N-acetyl-D-muramyl-L-alanylD-isoglutamyl-meso-diaminopimelic acid, or M-triDAP) comparison eff ects TLR4 agonist, lipopolysaccharide (LPS). demonstrate possibilities modulation cytokine production by using glycolysis inhibitors.
We performed a simultaneous analysis of cytokine expression and metabolic reprogramming macrophages upon combined stimulation NOD1 TLR4 receptors innate immunity. agonists boosted main parameters glycolysis (extracellular acidification rate, glucose consumption, lactate release). However, changes these were not greater than those induced by each individual receptor. At the same time, synergistically pro-inflammatory production mRNA at relatively late time points (4–9 hours) after addition...
Масютина А.М