A5083182385- Cancer, Hypoxia, and Metabolism
- Immune Response and Inflammation
- ATP Synthase and ATPases Research
- Mitochondrial Function and Pathology
- Immune cells in cancer
- Cancer-related Molecular Pathways
- Autophagy in Disease and Therapy
- Radiopharmaceutical Chemistry and Applications
- Laser Applications in Dentistry and Medicine
- Silicon Nanostructures and Photoluminescence
- NF-κB Signaling Pathways
- Nanoparticles: synthesis and applications
- Plant biochemistry and biosynthesis
- Advanced Nanomaterials in Catalysis
- Immune Cell Function and Interaction
- Neonatal Respiratory Health Research
- Neuroblastoma Research and Treatments
- Immune responses and vaccinations
- Natural product bioactivities and synthesis
- Sirtuins and Resveratrol in Medicine
- Cell death mechanisms and regulation
- Endoplasmic Reticulum Stress and Disease
- Immunotherapy and Immune Responses
- Pancreatic function and diabetes
Lomonosov Moscow State University
2016-2023
Moscow State University
2017-2020
A series of new betulinic and ursolic acid conjugates with a lipophilic triphenylphosphonium cation, meant to enhance the bioavailability mitochondriotropic action natural triterpenes, have been synthesized. The
Upon activation with pathogen-associated molecular patterns, metabolism of macrophages and dendritic cells is shifted from oxidative phosphorylation to aerobic glycolysis, which considered important for proinflammatory cytokine production. Fragments bacterial peptidoglycan (muramyl peptides) activate innate immune through nucleotide-binding oligomerization domain (NOD) 1 and/or NOD2 receptors. Here, we show that NOD1 agonists induce early glycolytic reprogramming human monocyte-derived...
The dependence of tumors on glycolysis for ATP generation offers a rationale therapeutic strategies aimed at selective inhibition the glycolytic pathway. Analysis tumor cell responses to anticancer drugs revealed that by 2‐deoxy‐D‐glucose (2‐ DG ) generally augmented apoptotic response; however, in HCT 116 human colon carcinoma cells, apoptosis was suppressed. A comparison neuroblastoma SK ‐N‐ BE (2) and cells revealed, contrast 116, 2‐ alone able induce death. In decrease levels upon...
Interactions between pattern-recognition receptors shape innate immune responses to pathogens. NOD1 and TLR4 are synergistically interacting playing a pivotal role in the recognition of Gram-negative bacteria. However, mechanisms their cooperation poorly understood. It is unclear whether synergy produced at level signaling pathways downstream or more distal levels such as gene transcription. We analyzed sequential stages human macrophage activation by combination agonists...
Nanocontainers based on solid materials have great potential for drug delivery applications. However, since nanocontainer-mediated can alter the internalization pathways and metabolism, it is important to find out what are mechanisms of cancer cell death induced by nanocontainers and, moreover, possible regulate them. Here, we report detailed investigation kinetics intracellular spatial distribution porous silicon nanoparticles (PSi NPs) loaded with doxorubicin (DOX) response cells treatment...
Macrophages activated through a pattern-recognition receptor (PRR) enter transient state of tolerance characterized by diminished responsiveness to restimulation the same receptor. Signaling-based and epigenetic mechanisms are invoked explain this innate tolerance. However, these two groups should result in different outcomes. The scenario (silencing effector genes) predicts that activation PRR broadly cross-tolerize agonists unrelated PRRs, whereas signaling-based (inhibition signaling...
A hypoxic environment of rapidly growing tumor cells makes them resistant to antitumor drugs. Mimicking hypoxia with iron chelator deferoxamine, suppressed cell death induced by widely used anticancer drugs doxorubicin or cisplatin. Deferoxamine decreased the number dead (detached) cells, size SubG1 population, release cytochrome c, and processing caspase-3 in HCT116 colon carcinoma treated cisplatin doxorubicin. Deferoxamine-mediated suppression apoptosis correlated level pro-apoptotic...
The majority of anticancer drugs are DNA-damaging agents, and whether or not they may directly target mitochondria remains unclear. In addition, tumors such as neuroblastoma exhibit addiction to glutamine in spite it being a nonessential amino acid. Our aim was evaluate the direct effect widely used on mitochondrial activity combination with withdrawal, possible apoptotic effects interaction. results revealed that etoposide inhibits respiratory chain Complex I causing leakage electrons...
Photobiomodulation (PBM) using nonionizing light sources, including lasers, light-emitting diodes, and/or broadband light, in the visible (400 to 700 nm) and near-infrared (700 1100 electromagnetic spectrum, has been successfully exploited for multiple therapeutic purposes. We analyzed effects of red infrared irradiation on neuroblastoma cells an vitro rotenone model Parkinson's disease. Cell viability was assessed by colorimetric assay metabolic activity (MTT test), oxygen consumption rate...
Аэробный гликолиз не играет незаменимой роли в продукции провоспалительных цитокинов дендритными клетками 1 Федеральное государственное бюджетное учреждение «Государственный научный центр «Институт иммунологии» Федерального медико-биологического агентства, 115522, г.Москва, Российская Федерация 2 образовательное высшего образования «Московский государственный университет имени М.В.Ломоносова», 119991, 3 автономное Российский исследовательский медицинский им.Н.И.Пирогова Министерства...