И. В. Демко
A5003735551- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory and Cough-Related Research
- Human Health and Disease
- Pediatric health and respiratory diseases
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Healthcare Systems and Public Health
- Inhalation and Respiratory Drug Delivery
- Pneumonia and Respiratory Infections
- Respiratory Support and Mechanisms
- Urticaria and Related Conditions
- IL-33, ST2, and ILC Pathways
- COVID-19 and healthcare impacts
- Respiratory viral infections research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Calcium signaling and nucleotide metabolism
- Cardiovascular Disease and Adiposity
- COVID-19 and Mental Health
- Vitamin D Research Studies
- Allergic Rhinitis and Sensitization
- Adipokines, Inflammation, and Metabolic Diseases
- Sarcoidosis and Beryllium Toxicity Research
- Cardiovascular Health and Disease Prevention
- Amyloidosis: Diagnosis, Treatment, Outcomes
Krasnoyarsk Regional Clinical Hospital
2015-2025
Krasnoyarsk State Medical University
2016-2025
Ministry of Health of the Russian Federation
2016-2025
Krasnoyarsk Scientific Center
2021
Background: Estimation suggests that at least 4 million people die, annually, as a result of chronic respiratory disease (CRD). The Global Alliance against Chronic Respiratory Diseases (GARD) was formed following mandate from the World Health Assembly to address this serious and growing health problem. Objectives: To investigate prevalence CRD in Russian symptomatic patients evaluate frequency major risk factors for Russia. Methods: A cross-sectional, population-based epidemiological study...
Hypersensitivity pneumonitis (HP) is an inflammatory and/or fibrotic lung disease that occurs in response to repeated inhalation of broad-spectrum aerosol antigens. The prevalence HP ranges from 0.3 0.9 cases per 100,000 population. basis treatment therapy includes glucocorticoids, immunosuppressants, and antifibrotic drugs. target audience these clinical recommendations are general practitioners, pulmonologists, pathologists, radiologists, medical rehabilitation specialists. Methods. Each...
Aim. To study the clinical course specifics of coronavirus disease 2019 (COVID-19) and comorbid conditions in COVID-19 survivors 3, 6, 12 months after recovery Eurasian region according to AKTIV register. Material methods. The register was created at initiative Association Therapists. is divided into 2 parts: 1 2. currently includes 6300 patients, while — 2770. Patients diagnosed with receiving in- outpatient treatment have been anonymously included on registry. following 7 countries...
The international AKTIV register presents a detailed description of out- and inpatients with COVID-19 in the Eurasian region. It was found that hospitalized patients had more comorbidities. In addition, these were older there men than among outpatients. Among traditional risk factors, obesity hypertension significant negative effect on prognosis, which for 60 years age older. comorbidities, CVDs maximum this other type 2 1 diabetes, chronic kidney disease, obstructive pulmonary cancer anemia...
Bronchial asthma is a heterogeneous disease that requires identification of its phenotype and personalized approach to therapy. At the same time, despite wide range therapeutic options, many patients with cannot achieve control over disease. Methodology . The target audience these clinical recommendations are general practitioners, therapists, pediatricians, allergologists-immunologists, pulmonologists, functional diagnostics doctors. Each thesis-recommendation about diagnostic procedures...
The Federal Guidelines on preventive vaccination against pneumococcal infections in adults were developed by experts of Russian Respiratory Society and National Non-profit Association Specialists for Control Healthcare-Associated Infections. Studies published during the previous 5 years selected from EMBASE, MEDLINE , PubMed databases Cochrane library reviewed independent with consideration practical physicians' opinions. results this analysis underlay guidelines. Quality evidence strength...
The COVID-19 pandemic, which began in December 2019, was caused by the new coronavirus SARS-CoV-2. SARS-CoV-2 is a shell virus containing single positive chain genome and using angiotensin converting enzyme 2 (ACE2) as cell entry receptor. targeting of on several tissues expressing ACE2 explains multifactorial pattern symptoms: fever, dry cough, myalgia, fatigue shortness breath. These symptoms do not always stop after COVID-19, may reappear within 12 weeks, indicates development post-COVID...
Pneumococcal infection remains a serious problem in practical health care, being one of the most common causes death from infectious diseases. Vaccination is only way to significantly affect morbidity and mortality pneumococcal reduce level resistance antibacterial drugs. The article analyzes experience vaccination against adults risk groups.
Introduction. One of the most common complications novel coronavirus infection (COVID-19) involves respiratory system disorders, particularly bronchial obstruction. Aim. To highlight importance vigilance regarding onset diseases, including asthma, in post-COVID period. Results. This article describes a clinical case newly diagnosed severe asthma 35-year-old patient following COVID-19. A notable feature patient’s condition was prolonged eosinophilia. Sensitization to inhalant allergens ruled...
An analysis and systematization of scientific literature on the combination asthma COVID-19 was conducted using databases PubMed/MEDLINE eLIBRARY.RU. The data relationship between are shown to be contradictory. mechanism inflammation development its characteristics in new coronavirus infection discussed. significant role natural killer (NK) cells T-natural (T-NK) pathogenesis disease is emphasized. importance type risk SARS-CoV-2 concluded. Information dual nature regarding use inhaled...
The modern concept of a personalized approach to studying the relationship between diseases contributes an in-depth multimorbidity study. Asthma is one most common pathologies among chronic respiratory diseases, characterized by wide heterogeneity and high comorbidity, especially with cardiovascular in older age group. Due difficulties differential diagnosis these their mutually aggravated course, measures for prevention heart failure (HF) asthma patients should be structured.The aim review...
Although there is a generally accepted consensus on the therapeutic objectives for bronchial asthma (BA) management and availability of numerous effective treatment modalities, disease control remains suboptimal in substantial proportion patients globally. This review evaluates data from clinical studies assessing efficacy, safety, rationale use combination drug budesonide/salbutamol routine practice. Publications indexed Google Scholar Web Science databases 2000 to 2023 were analyzed as...
The organizer of the registers “Dynamics analysis comorbidities in SARSCoV-2 survivors” (AKTIV) and “Analysis hospitalizations comorbid patients infected during second wave SARS-CoV-2 outbreak” (AKTIV 2) is Eurasian Association Therapists (EAT). Currently, there are no clinical registries region designed to collect analyze information on long-term outcomes COVID-19 survivors with conditions. aim register assess impact a novel coronavirus infection course chronic non-communicable diseases 3,...
Aim. To assess the effectiveness of vaccination against Omicron and Delta variants according to international registry "Dynamics Analysis Comorbidities in SARS-CoV-2 Survivors" (AKTIV-4). Material methods. The AKTIV-4 included men women over 18 years age with a diagnosis coronavirus disease 2019 (COVID-19) (oropharyngeal nasopharyngeal swabs, antibody titers, typical computed tomography performance), undergoing hospital treatment. A total 3543 patients from 25 medical centers 7 countries...
Aim. Study the impact of various combinations comorbid original diseases in patients infected with COVID-19 later on disease progression and outcomes new coronavirus infection. Materials methods. The ACTIV registry was created Eurasian Association Therapists initiative. 5,808 have been included registry: men women treated at hospital or home. ClinicalTrials.gov ID NCT04492384. Results. Most (oCDs). Polymorbidity assessed by way simple counting oCDs is an independent factor negative COVID-19....
Background: Krasnoyarsk region is a territory with the widespread risk factors for chronic obstructive pulmonary disease (COPD) such as tobacco smoke, air pollution, and occupational exposure. An assessment of COPD prevalence based on medical diagnosis statistics underestimates true prevalence. This study aims to evaluate how examinations may increase accuracy estimates Methods: True was estimated number patients established supplemented by additional cases detected during per 1,000...
Aim To study the effect of regular drug therapy for cardiovascular and other diseases preceding COVID-19 infection on severity outcome based data ACTIVE (Analysis dynamics Comorbidities in paTIents who surVived SARS-CoV-2 infEction) registry.Material methods The registry was created at initiative Eurasian Association Therapists. includes 5 808 male female patients diagnosed with treated a hospital or home due protection patients' privacy (data nasal throat smears; antibody titer; typical CT...
Aim . The study of clinical and functional characteristics, features pharmacotherapy the level adherence in severe difficult-to-treat bronchial asthma real practice to optimize pathogenetic therapy measures. Materials methods 143 patients diagnosed with were examined. Patients divided into 2 groups: asthma. Examination included: anamnestic method, physical examination, filling out ACQ-5 questionnaire, AST, Morisky-Green instrumental (spirography bronchodilator), laboratory methods. Results...
Biological therapy of bronchial asthma (BA) is a modern method treating severe forms the disease, that are uncontrolled by traditional pharmacotherapeutic approaches. Currently, 5 monoclonal antibody (AT) preparations registered in world for treatment (SBA) T2 endotype (T2-SBA) – antibodies, binding to immunoglobulin (Ig) E (anti-IgE omalizumab), interleukin antagonists (IL)-5 (anti-IL-5 mepolizumab, resizumab) and its receptor (anti-IL-5Rα benralizumab), as well selectively bind IL-4 -13...
Aim . To analyze newly diagnosed diseases and features of the post-COVID course in patients after a coronavirus disease 2019 (COVID-19) within 12-month follow-up. Material methods A total 9364 consecutively hospitalized were included ACTIV registry. Enrollment began on June 29, 2020, was completed March 30, 2021, corresponding to first second waves pandemic. Demographic, clinical, laboratory data, computed tomography (CT) results, information about inhospital clinical complications COVID-19...
Introduction . The natural course of some interstitial lung diseases (ILD) is characterized by progressive fibrosing phenotype resembling idiopathic pulmonary fibrosis (IPF). Until recently, the antifibrotic drug nintedanib was approved for treatment only ILD which IPF. A new indication this has been registered in Russian Federation 2021 includes other ILDs with (PF-ILDs) and associated systemic scleroderma (SS-ILD). aim publication to describe general considerations decision...
Asthma and chronic obstructive pulmonary disease remain major problems of medicine, still there is need to improve the level quality diagnosis these diseases. Primary care physicians (general practitioners, therapists) should be involved widely actively in this process. To simplify diagnosis, special questionnaires have been developed, they can used a real clinical practice. Only approach will bring statistical data closer true prevalence diseases their treatment.