Akpay Sarybaev
A5013941680- High Altitude and Hypoxia
- Pulmonary Hypertension Research and Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Long-Term Effects of COVID-19
- Neuroscience of respiration and sleep
- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- Travel-related health issues
- Cardiac Imaging and Diagnostics
- Cardiovascular and Diving-Related Complications
- Healthcare Systems and Public Health
- Cardiovascular Disease and Adiposity
- Heme Oxygenase-1 and Carbon Monoxide
- Cardiac Health and Mental Health
- Cardiac Ischemia and Reperfusion
- Cardiovascular Function and Risk Factors
- Spaceflight effects on biology
- Climate Change and Health Impacts
- Blood Pressure and Hypertension Studies
- Cardiovascular Issues in Pregnancy
- Cardiovascular Health and Risk Factors
- Heart Rate Variability and Autonomic Control
- Cardiac Arrest and Resuscitation
- Human Health and Disease
- Congenital Heart Disease Studies
National Center of Cardiology and Internal Medicine
2015-2024
Ministry of Health
2022-2024
Cardio-Pulmonary Institute
2022
Justus-Liebig-Universität Gießen
2022
German Center for Lung Research
2022
Global Health Research Center of Central Asia
2018-2021
Kyrgyz State Medical Academy
2016-2017
University of Cambridge
2002
Hammersmith Hospital
1999-2002
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Aim. To study the clinical course specifics of coronavirus disease 2019 (COVID-19) and comorbid conditions in COVID-19 survivors 3, 6, 12 months after recovery Eurasian region according to AKTIV register. Material methods. The register was created at initiative Association Therapists. is divided into 2 parts: 1 2. currently includes 6300 patients, while — 2770. Patients diagnosed with receiving in- outpatient treatment have been anonymously included on registry. following 7 countries...
The international AKTIV register presents a detailed description of out- and inpatients with COVID-19 in the Eurasian region. It was found that hospitalized patients had more comorbidities. In addition, these were older there men than among outpatients. Among traditional risk factors, obesity hypertension significant negative effect on prognosis, which for 60 years age older. comorbidities, CVDs maximum this other type 2 1 diabetes, chronic kidney disease, obstructive pulmonary cancer anemia...
Pulmonary hypertension (PH) is a life-threatening disease, characterized by excessive pulmonary vascular remodeling, leading to elevated arterial pressure and right heart hypertrophy. PH can be caused chronic hypoxia, hyper-proliferation of smooth muscle cells (PASMCs) apoptosis-resistant microvascular endothelial (PMVECs). On reexposure normoxia, hypoxia-induced in mice reversible. In this study, the authors aim identify novel candidate genes involved remodeling specifically...
In response to various stressors, cardiac chambers undergo structural remodeling. Long-term exposure of the right ventricle (RV) pressure or volume overload leads its maladaptive remodeling, associated with RV failure and increased mortality. While left ventricular adverse remodeling is well understood therapeutic options are available emerging, remains underexplored, no specific therapies currently available. Accumulating evidence implicates role mast cells in Mast produce release numerous...
Previous studies have suggested a genetic component in susceptibility to hypoxia-induced pulmonary hypertension. We therefore estimated the prevalence of high-altitude hypertension (HAPH) Kyrgyz population and whether insertion/deletion (I/D) polymorphism angiotensin-converting enzyme (ACE) gene associates with HAPH. An electrocardiographic survey 741 highlanders demonstrated electrocardiogram signs cor pulmonale 14% subjects. Pulmonary artery hemodynamics measured an independent group 136...
ABSTRACT Tuberculous sputum contains multiple Mycobacterium tuberculosis populations with different requirements for isolation in vitro . These include cells that form colonies on solid media (plateable M. ), requiring standard liquid medium growth (nonplateable and supplementation of culture supernatant (SN) (SN-dependent ). Here, we describe protocols the cryopreservation direct assessment antimicrobial tolerance these within sputum. Our results show first-line drugs achieved only modest...
Disclaimer. The EAC Guidelines represent the views of EAC, and were produced after careful consideration scientific medical knowledge, evidence available at time their publication. is not responsible in event any contradiction, discrepancy, and/or ambiguity between other official recommendations or guidelines issued by relevant public health authorities, particular relation to good use healthcare therapeutic strategies. Health professionals are encouraged take fully into account when...
The medical risks of travel and stay at high altitude are well known. Many more people for recreation to lower but still significant altitudes. To investigate the quality sleep sleep-related breathing disorders (SRBD) that we performed full polysomnography in nine young volunteers lowland (760 m above sea level) on first sixth night after ascent 3,200 m. There have been few studies such populations. subjects were nonsmoking healthy males aged 20.3 +/- 3.5 years with normal spirometry...
Disclaimer The EAC Guidelines represent the views of EAC, and were produced after careful consideration scientific medical knowledge, evidence available at time their publication. is not responsible in event any contradiction, discrepancy, and/or ambiguity between other official recommendations or guidelines issued by relevant public health authorities, particular relation to good use healthcare therapeutic strategies. Health professionals are encouraged take fully into account when...
Chronic high altitude hypoxia leads to an increase in red cell numbers and hemoglobin concentration. However, the effects of long-term intermittent on concentration have not been studied. The aim this study was evaluate levels workers commuting between elevation 3,800 m (2-week working shift) lowland below 1,700 (2 weeks holiday). A total 266 healthy males, aged from 20 69 years (mean age 45.9 ± 9.3 years), were included into study. duration exposure ranged 0 21 years. Any cardiac or...
The organizer of the registers “Dynamics analysis comorbidities in SARSCoV-2 survivors” (AKTIV) and “Analysis hospitalizations comorbid patients infected during second wave SARS-CoV-2 outbreak” (AKTIV 2) is Eurasian Association Therapists (EAT). Currently, there are no clinical registries region designed to collect analyze information on long-term outcomes COVID-19 survivors with conditions. aim register assess impact a novel coronavirus infection course chronic non-communicable diseases 3,...
Recent work suggests that treatment with inhaled β 2 -agonists reduces the incidence of high-altitude pulmonary edema in susceptible subjects by increasing respiratory epithelial sodium transport. We estimated ion transport transepithelial nasal potential difference (NPD) measurements 20 normal male before, during, and after a stay at 3,800 m. NPD hyperpolarized on ascent to m ( P < 0.05), but change superperfusion amiloride or isoprenaline was unaffected. Vital capacity (VC) fell as did...
Aim. Study the impact of various combinations comorbid original diseases in patients infected with COVID-19 later on disease progression and outcomes new coronavirus infection. Materials methods. The ACTIV registry was created Eurasian Association Therapists initiative. 5,808 have been included registry: men women treated at hospital or home. ClinicalTrials.gov ID NCT04492384. Results. Most (oCDs). Polymorbidity assessed by way simple counting oCDs is an independent factor negative COVID-19....
The analysis of experimental data demonstrates that platelets and neutrophils are involved in the no-reflow phenomenon, also known as microvascular obstruction (MVO). However, studies performed isolated perfused hearts subjected to ischemia/reperfusion (I/R) do not suggest involvement microembolization microthrombi this phenomenon. intracoronary administration alteplase has been found have no effect on occurrence MVO patients with acute myocardial infarction. Consequently, major events...
Aim To study the effect of regular drug therapy for cardiovascular and other diseases preceding COVID-19 infection on severity outcome based data ACTIVE (Analysis dynamics Comorbidities in paTIents who surVived SARS-CoV-2 infEction) registry.Material methods The registry was created at initiative Eurasian Association Therapists. includes 5 808 male female patients diagnosed with treated a hospital or home due protection patients' privacy (data nasal throat smears; antibody titer; typical CT...
By the middle of 2021, official global number coronavirus disease 2019 (COVID-19) patients was close to 230 million, but accounting for asymptomatic much higher. Consequences and rehabilitation after COVID-19 are particular interest raise many controversial unresolved issues. On May 18, Eurasian Association Therapists organized an international panel experts analyze challenges associated with post-COVID-19 period. This aimed develop approaches identify gaps in discussed interdisciplinary...
The protective effects of nitric oxide (NO), a physiological activator soluble guanylyl cyclase (sGC), have been reported in ischemia-reperfusion (I/R) syndrome the lung. Therefore, we studied BAY 41-2272, novel sGC stimulator, on I/R injury lung an isolated intact organ model. Lung was assessed by measuring weight gain and microvascular permeability (capillary filtration coefficient, K(fc)). Release reactive oxygen species (ROS) into perfusate measured during early reperfusion electron spin...
The EAC Guidelines represent the views of EAC, and were produced after careful consideration scientific medical knowledge, evidence available at time their publication. is not responsible in event any contradiction, discrepancy, and/or ambiguity between other official recommendations or guidelines issued by relevant public health authorities, particular relation to good use healthcare therapeutic strategies. Health professionals are encouraged take fully into account when exercising clinical...