A5078192209- Asthma and respiratory diseases
- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pediatric health and respiratory diseases
- Respiratory Support and Mechanisms
- Health, psychology, and well-being
- Allergic Rhinitis and Sensitization
- Tracheal and airway disorders
- Neonatal Respiratory Health Research
- Eosinophilic Disorders and Syndromes
- Respiratory and Cough-Related Research
- Inhalation and Respiratory Drug Delivery
- Healthcare Decision-Making and Restraints
- Neurogenetic and Muscular Disorders Research
- Biomarkers in Disease Mechanisms
- Urticaria and Related Conditions
- Parasitic infections in humans and animals
- Child Welfare and Adoption
- Spinal Cord Injury Research
- COVID-19 and Mental Health
- Amyotrophic Lateral Sclerosis Research
- Aortic aneurysm repair treatments
- Cardiovascular Syncope and Autonomic Disorders
- Vascular Anomalies and Treatments
Lithuanian University of Health Sciences
2020-2025
Hospital of Lithuanian University of Health Sciences Kaunas Clinics
2015-2022
In distinguishing the allergic asthma (AA) phenotype, it has been identified that specific biomarkers could assist; however, none of them are considered ideal. This study aimed to analyze three groups biologically active substances in serum. Twenty steroid-free AA patients, sensitized Dermatophagoides pteronyssinus, and sixteen healthy subjects (HSs) were enrolled this study. Blood samples collected from all patients. Additionally, patients underwent a bronchial allergen challenge (BAC) with...
The impaired production of extracellular matrix (ECM) proteins by airway smooth muscle cells (ASMC) and pulmonary fibroblasts (PF) is a part remodeling in asthma. This process might be influenced eosinophils that migrate to the abundantly secrete various cytokines, including TGF-β. We aimed investigate effect asthmatic on gene expression ECM ASMC PF. A total 34 study subjects were recruited: 14 with allergic asthma (AA), 9 severe non-allergic eosinophilic (SNEA), 11 healthy (HS). All AA...
Mepolizumab, which causes a decrease in the number of blood eosinophils, is used to treat patients with severe eosinophilic asthma (SEA). However, there relative lack data on dynamic changes eosinophil subtype distribution and their granule protein expression following anti-interleukin (IL)-5 treatment. Our objective was evaluate inflammatory-like (iEOS-like) resident-like (rEOS-like) CLC, EDN, EPX, ECP, MBP gene up 24 weeks treatment mepolizumab SEA patients. Ten free oral steroids 9...
Airway remodeling is a hallmark feature of asthma, and one its key structural changes increased airway smooth muscle (ASM) mass disturbed extracellular matrix (ECM) homeostasis. Eosinophil functions in asthma are broadly defined; however, we lack knowledge about eosinophil subtypes' interaction with lung cells their effect on the airway's local microenvironment. Therefore, investigated blood inflammatory-like eosinophils (iEOS-like) resident-like (rEOS-like) ASM via impact migration...
Enhanced contractility and migration of airway smooth muscle cells (ASMC) pulmonary fibroblasts (PF) are part remodeling in asthma. Eosinophils the central inflammatory that participate inflammation. However, role asthmatic eosinophils ASMC PF contractility, migration, differentiation to contractile phenotype has not yet been precisely described. A total 38 individuals were included this study: 13 steroid-free non-severe allergic asthma (AA) patients, 11 severe non-allergic eosinophilic...
Background The coronavirus disease 2019 (COVID-19) pandemic has put pressure on healthcare services, forcing the reorganisation of traditional care pathways. We investigated how physicians taking severe asthma patients in Europe reorganised care, and these changes affected patient satisfaction, control future care. Methods In this European-wide cross-sectional study, surveys were sent to with a physician-diagnosis asthma, physician specialists between November 2020 May 2021. Results 1101 268...
Anti-interleukin (IL) 5 is an effective treatment modality for inhibiting eosinophilic inflammation in patients with T2-high severe asthma. The aim of this study was to determine the clinical efficacy and serum levels type 2 inflammatory mediators during 24 weeks mepolizumab Eighteen asthma were enrolled study. All received 100 mg subcutaneously every 4 retested at 4, 12, weeks. A examination, control test (ACT), spirometry performed; fractional exhaled nitric oxide (FeNO) evaluated; blood...
Blood eosinophils can be described as inflammatory-like (iEOS-like) and lung-resident-like (rEOS-like) eosinophils. This study is based on the hypothesis that eosinophilopoetins such interleukin (IL)-3 IL-5 granulocyte-macrophage colony-stimulating factor (GM-CSF) alter proliferative properties of eosinophil subtypes may associated with expression their receptors We investigated 8 individuals severe nonallergic eosinophilic asthma (SNEA), 17 nonsevere allergic (AA), 11 healthy subjects (HS)....
Vaccination is vital for achieving population immunity to severe acute respiratory syndrome coronavirus 2, but vaccination hesitancy presents a threat widespread immunity. Vaccine acceptance in chronic potentially immunosuppressed patients largely unclear, especially with asthma. The aim of this study was investigate the experience people asthma.Questionnaires about beliefs (including Attitudes Examination (VAX) scale, measure hesitancy-related beliefs), side-effects, asthma control and...
Eosinophilic inflammation is one of the main pathophysiological features in asthma. Two subtypes eosinophils exist lung and systemic circulation: lung-resident (rEOS) inflammatory (iEOS). We evaluated expression α4β1 αMβ2 integrins eosinophil their influence on airway smooth muscle (ASM) cell proliferation viability included 16 severe non-allergic eosinophilic asthma (SNEA) patients, 13 steroid-free, non-severe allergic (AA) 12 healthy control subjects (HS). For AA a bronchial allergen...
<b>Introduction</b> MicroRNAs (miRNAs) are non-coding RNAs that regulate gene expression at the post-transcriptional level. In context of allergic asthma (AA), several miRNAs have been found to exhibit differential in eosinophils; however no data about eosinophil subtypes-specific and their mediated regulation target genes known so far <b>Aim</b> To investigate changes selected miRNA-target genes (PRG2,CYSTLR1,RANTES,IL-1β) lung-resident-like eosinophils (rEOS)-like...
Background: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder, and although the diagnosis primarily based on clinical criteria, ENMG, as “gold standard”, does not always show detectable changes. Therefore, our study suggests that alterations in echogenicity heterogeneity of phrenic nerve (PN) may serve potential additional diagnostic tools for ALS. Methods: Our included 32 patients ALS group 64 individuals control group. Each participant underwent an interview...
Eosinophils are central inflammatory cells in asthma; however, a portion of patients with chronic obstructive pulmonary disease (COPD) have blood or sputum eosinophilia, condition termed eosinophilic COPD (eCOPD), which may contribute to the progression disease. We hypothesize that inflammation eCOPD is related Type 2 (T2)-high seen asthma and serum mediators might help us identify T2-high choose an appropriate personalized treatment strategy. Thus, we aimed investigate ten levels compare...