A5063676995- Asthma and respiratory diseases
- Eosinophilic Esophagitis
- Pediatric health and respiratory diseases
- IL-33, ST2, and ILC Pathways
- Chronic Obstructive Pulmonary Disease (COPD) Research
Lithuanian University of Health Sciences
2022-2025
Vilnius University
2024
Mepolizumab, which causes a decrease in the number of blood eosinophils, is used to treat patients with severe eosinophilic asthma (SEA). However, there relative lack data on dynamic changes eosinophil subtype distribution and their granule protein expression following anti-interleukin (IL)-5 treatment. Our objective was evaluate inflammatory-like (iEOS-like) resident-like (rEOS-like) CLC, EDN, EPX, ECP, MBP gene up 24 weeks treatment mepolizumab SEA patients. Ten free oral steroids 9...
Eosinophils are central inflammatory cells in asthma; however, a portion of patients with chronic obstructive pulmonary disease (COPD) have blood or sputum eosinophilia, condition termed eosinophilic COPD (eCOPD), which may contribute to the progression disease. We hypothesize that inflammation eCOPD is related Type 2 (T2)-high seen asthma and serum mediators might help us identify T2-high choose an appropriate personalized treatment strategy. Thus, we aimed investigate ten levels compare...
<b>Introduction:</b> Acute episode of allergic asthma (AA) is associated with increased blood and airway eosinophilia. miRNAs act as regulators gene expression we hypothesized that distinct lung-resident-like eosinophils (rEOS-like) inflammatory-like (iEOS-like) biological properties are related subtype-specific in acute AA <b>Aim:</b> To investigate the effect bronchial allergen challenge (BAC) <i>D.pteronyssinus</i> on miR-185-5p, miR-1290, miR-146b-5p, miR-320b, miR-21-5p rEOS-like...
<b>Introduction:</b> Blood inflammatory-like (iEOS-like) and lung resident-like (rEOS-like) eosinophils are distinct in biological properties. Therefore, activation by eosinophilopoetins (interleukin (IL) 3, IL-5 granulocyte-macrophage colony-stimulating factor (GM-CSF)) might have different effect on blood eosinophil subtypes promoted airway smooth muscle (ASM) cells proliferation severe non-allergic asthma (SNEA). <b>The aim:</b> To investigate the of rEOS-like iEOS-like proliferative...
<b>Introduction:</b> Blood eosinophil subtypes are different in biological properties. Supposedly various eosinophilopoetins can differentially affect functions asthma. <b>The aim:</b> To investigate interleukin (IL) 3, IL-5 and granulocyte-macrophage colony-stimulating factor (GM-CSF) effect on lung-resident-like (rEOS-like) inflammatory-like (iEOS-like) promoted airway smooth muscle (ASM) cells proliferation allergic asthma (AA). <b>Research methods:</b> We included 8 steroid-naive,...