A5012564817- HIV/AIDS Research and Interventions
- HIV, Drug Use, Sexual Risk
- HIV-related health complications and treatments
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Adolescent Sexual and Reproductive Health
- Hepatitis C virus research
- Health Systems, Economic Evaluations, Quality of Life
- Liver Disease Diagnosis and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Sex work and related issues
- Liver Disease and Transplantation
- Adolescent and Pediatric Healthcare
- Child and Adolescent Psychosocial and Emotional Development
- Thermal Regulation in Medicine
- Delphi Technique in Research
- Attachment and Relationship Dynamics
- Maternal Mental Health During Pregnancy and Postpartum
- Cleft Lip and Palate Research
- Climate Change and Health Impacts
- Cardiovascular Health and Disease Prevention
- Craniofacial Disorders and Treatments
- Pregnancy and Medication Impact
- Economic Theory and Policy
- Tracheal and airway disorders
University of Mississippi Medical Center
2024-2025
Brighton and Sussex Medical School
2010-2025
University Hospitals Sussex NHS Foundation Trust
2015-2025
University of Sussex
2012-2023
University College London
2017
Royal Sussex County Hospital
2010-2014
South Thames College
2010
Imperial College London
2010
University of Brighton
2008-2010
Recreational drug use in men who have sex with (MSM) is of concern because it might be linked to the transmission HIV and other sexually transmitted infections. Evidence about HIV-diagnosed MSM UK limited by representativeness study populations. We describe patterns associations sexual behaviours UK.We used data from cross-sectional ASTRA study, which recruited participants aged 18 years or older eight outpatient clinics between Feb 1, 2011, Dec 31, 2012. examined for MSM, assessing...
Abstract Although initiatives are under way in the UK to diagnose HIV infection early, late presentation is still a major issue and often results serious health complications for individual has implications society, including high costs increased rates of transmission. Intervention strategies have aimed at increasing testing opportunities but significant proportion those with either decline or continue test late. The main objective this study identify ideas themes as why was not carried out...
Background: Two nucleoside reverse transcriptase inhibitors (NRTIs) and efavirenz (EFV) is a recommended initial regimen for HIV-1. Most EFV-related central nervous system (CNS) toxicity resolves early though symptoms may persist; we studied switching to etravirine (ETR) in these individuals. Methods: A randomized, double-blind trial patients with viral suppression but ongoing CNS adverse events after more than 12 weeks EFV. Patients received 2NRTI/EFV/ETR-placebo (delayed switch) or...
Disclosure of HIV status to family, friends, and a stable partner may be linked improved health outcomes for people living with HIV. This study assessed whether non-disclosure is associated psychological symptoms, non-adherence antiretroviral therapy (ART), viral load (VL) non-suppression. A total 3258 HIV-diagnosed individuals in the UK completed confidential ASTRA questionnaire (2011–2012). Participants reported they told anyone had HIV; which confidant(s) (friends, work colleagues,...
BackgroundThe length of time that people with HIV on antiretroviral therapy (ART) viral load suppression will be able to continue before developing rebound is unknown. We aimed investigate the rate first in have achieved initial ART, determine factors associated rebound, and use these estimates predict long-term durability suppression.MethodsThe UK Collaborative Cohort (UK CHIC) Study an ongoing multicentre cohort study brings together a standardised format data attending clinics around UK....
Germline genetic testing affords multiple opportunities for women with breast cancer, however, current UK NHS models delivery of germline are clinician-intensive and only a minority cancer cases access testing.
<h3>Objective</h3> HIV transmission is ongoing among men who have sex with (MSM) in the UK. Sex without a condom (condomless sex, CLS) main risk factor. We investigated prevalence of and factors associated types CLS. <h3>Methods</h3> Cross-sectional questionnaire study UK clinics 2011/2012 (ASTRA). MSM diagnosed for ≥3 months reported on anal vaginal CLS HIV-serodifferent partners (CLS-D) HIV-seroconcordant (CLS-C) previous 3 months. Mutually exclusive sexual behaviours were as follows: (1)...
To determine uptake of home sampling kit (HSK) for STI/HIV compared to clinic-based testing, whether the availability HSK would increase STI testing rates amongst HIV infected MSM, and those attending a community-based clinic historical control. Prospective observational study in three facilities providing services Brighton, UK was conducted. Adult MSM attending/contacting GUM requesting an screen (group 1), routine outpatient 2), rapid service 3) were eligible. Participants required have no...
Objectives: To evaluate the prevalence, impact, and risk factors for pain among a cohort of human immunodeficiency virus (HIV)-infected adults treated with combination antiretroviral therapy if indicated according to current guidelines. Methods: This was cross-sectional epidemiological observational study. All patients attending 1 HIV-outpatient center in United Kingdom 10-month period were eligible. Patients completed validated questionnaire enquiring about demographics, HIV factors,...
Abstract Background There are limited data on how historical nucleoside reverse transcriptase inhibitor (NRTI) resistance-associated mutations (RAMs) other than M184V/I, affect the activity of B/F/TAF. We evaluated outcomes switching virologically suppressed (HIV-1 RNA < 50 copies/mL) individuals harbouring major RAMs from boosted protease (bPI)-based therapy to Methods Participants had various genotypic patterns including ≤2 thymidine analogue (TAMs), and NRTI (NAMs), no integrase...
<title>Abstract</title> <bold>Background</bold> Ascites remains the most common complication of cirrhosis and a frequent reason for hospitalisation in advanced chronic liver disease (ACLD). is associated with significant symptom burden, caregiver workload poor health-related quality life (HRQoL). Once refractory to treatment, median survival poor. Many ascites (RA) will neither receive transjugular intrahepatic portosystemic shunt (TIPS) nor transplant. Palliative care underutilised...
Objective Accurate current PROCEDURAL TERMINOLOGY (CPT) coding is essential to healthcare costs and fair reimbursement. In craniofacial (CF) surgery, specific codes for procedures like mandibular distraction cranial remodeling are lacking, leading unclear standards that may undervalue complex techniques. This study hypothesizes variability in billing exists aims characterize these trends. Design & Setting A 21-question survey was distributed via email. Participants Members of the...
The main objectives of this study are to investigate the psychosocial issues for young people who decline chlamydia testing as part national screening programme in UK and consider implications future opportunistic screening. Transcripts qualitative semi-structured interviews were analysed using interpretative phenomenological analysis identify themes. involved 14 aged 16–24 years declined tests non-health-care settings programme. was conducted educational where is available. Four interlinked...
The aim of the study was to assess, among people living with HIV, knowledge their latest HIV viral load (VL) and CD4 count.
Life expectancy for people diagnosed with HIV has improved dramatically however the number of new infections in UK remains high. Understanding patterns sexual behaviour among living HIV, and factors associated having condom-less sex, is important informing prevention strategies clinical care. In addition, view current interest a policy early antiretroviral treatment (ART) all UK, it particular importance to assess whether ART use increased levels sex. this context ASTRA study was designed...
The number of HIV-positive people aged ≥50 years is rising each year. We measured the prevalence non-infectious illnesses and their risk factors described healthcare use in this UK population. A cross-sectional, observational study was conducted at an outpatient HIV specialist clinic south east England. Patients age were invited to complete questionnaires measuring demographics, illnesses, medication use, lifestyle utilisation. response rate 67%. Of 299 participants, 84% reported ≥1 comorbid...
<h3>Objectives</h3> To understand which aspects of general practitioner (GP) and HIV clinic appointments people living with (PLWHIV) most value when seeking advice for new health problems. <h3>Methods</h3> A discrete choice experiment using a convenience sample diagnosed HIV. Participants were recruited from 14 clinics in the South East England between December 2014 April 2015. ORs calculated conditional logit (CLOGIT) latent class models (LCMs). <h3>Results</h3> total 1106 questionnaires...
Transmission of Hepatitis C virus (HCV) among HIV-positive men who have sex with (MSM) in the United Kingdom is ongoing. We explore associations between self-reported sexual behaviours and drug use cumulative HCV prevalence, as well new diagnosis.ASTRA a cross-sectional questionnaire study including 2,248 HIV-diagnosed MSM under care during 2011-2012. Socio-demographic, lifestyle, HIV-related behaviour data were collected study. One thousand seven hundred fifty two (≥70%) consented to...
Failures of post-exposure prophylaxis following sexual exposure (PEPSE) to prevent seroconversion have been reported and are often associated with ongoing risk exposure. Understanding why men who sex (MSM) access PEPSE on some occasions not others may lead more effective health promotion disease prevention strategiesA qualitative study design using semi-structured interviews 15 MSM within 6 months them initiating treatment at an HIV outpatient service in Brighton, UK.PEPSE seeking was...
Objectives Maraviroc may reduce hepatic inflammation in people with HIV and non-alcoholic fatty liver disease (HIV-NAFLD) through CCR5-receptor antagonism, which warrants further exploration. Methods We performed an open-label 96-week randomised-controlled feasibility trial of maraviroc plus optimised background therapy (OBT) versus OBT alone, a 1:1 ratio, for virologically-suppressed HIV-1 NAFLD without cirrhosis. Dosing followed recommendations the Summary Product Characteristics...
<h3>Background</h3> Since the introduction of highly active antiretroviral therapy (HAART) in late 1990s, individuals with HIV are living longer and beginning to experience chronic diseases ageing. Alongside side effects HAART therapy, these may be better managed community by generalists rather than specialists. <h3>Aim</h3> To explore GPs9 current perceptions barriers their involvement managing patients HIV. <h3>Design study</h3> Postal questionnaire. <h3>Setting</h3> Practices within a...