A5089079211- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Contact Dermatitis and Allergies
- Drug-Induced Adverse Reactions
- Dermatology and Skin Diseases
- Asthma and respiratory diseases
- Urticaria and Related Conditions
- Autoimmune Bullous Skin Diseases
- Virus-based gene therapy research
- RNA Interference and Gene Delivery
- Cutaneous Melanoma Detection and Management
- Monoclonal and Polyclonal Antibodies Research
- Pharmaceutical studies and practices
- Nail Diseases and Treatments
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Nonmelanoma Skin Cancer Studies
- Mast cells and histamine
- Healthcare and Venom Research
- Health and Medical Studies
- Transgenic Plants and Applications
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Immunotherapy and Immune Responses
- Occupational exposure and asthma
- Insect and Pesticide Research
Philipps University of Marburg
2016-2025
Universitätsklinikum Gießen und Marburg
2016-2025
University of Toronto
2023
Hospital for Sick Children
2023
SickKids Foundation
2023
Justus-Liebig-Universität Gießen
2008-2010
Ludwig-Maximilians-Universität München
1996-2009
Institut für Urheber- und Medienrecht
2008
Universitätsmedizin Greifswald
2007
LMU Klinikum
2002-2006
Not available.
No approved treatment for peanut allergy exists children younger than 4 years of age, and the efficacy safety epicutaneous immunotherapy with a patch in toddlers are unknown. We conducted this phase 3, multicenter, double-blind, randomized, placebo-controlled trial involving 1 to 3 age confirmed by food challenge. Patients who had an eliciting dose (the necessary elicit allergic reaction) 300 mg or less protein were assigned 2:1 ratio receive delivered means (intervention group) placebo...
Abstract Correction of an imbalance between allergen-specific T cell subsets is considered a critical event in establishing allergen tolerance by specific immunotherapy (SIT). In comprehensive, longitudinal study, distinct populations and Ig subtypes were analyzed subjects allergic to birch pollen during decisive time points SIT (i.e., induction maintenance phase), as well out season. An increase Bet v 1-specific, IL-10–secreting cells, fulfilling the criteria inducible type 1 regulatory...
Anti-IgE therapeutics interfere with the ability of IgE to bind its receptors on effector cells. Here we report crystal structure an anti-IgE single-domain antibody in complex Fc fragment, revealing how inhibits interactions between and two FcεRI CD23. The epitope overlaps only slightly FcεRI-binding site but significantly CD23-binding site. Solution scattering studies reveal that binding induces a half-bent conformation well-known bent extended conformations. acts as functional homolog CD23...
BackgroundComponent resolution recently identified distinct sensitization profiles in honey bee venom (HBV) allergy, some of which were dominated by specific IgE to Api m 3 and/or 10, have been reported be underrepresented therapeutic HBV preparations.ObjectiveWe performed a retrospective analysis component-resolved HBV-allergic patients and association with treatment outcome.MethodsHBV-allergic who had undergone controlled sting challenge after at least 6 months immunotherapy (n = 115)...
BM32 is a grass pollen allergy vaccine based on recombinant fusion proteins consisting of nonallergenic peptides from the IgE-binding sites 4 major allergens and hepatitis B preS protein.We sought to study safety clinical efficacy immunotherapy (allergen immunotherapy) with in patients pollen-induced rhinitis controlled asthma.A double-blind, placebo-controlled, multicenter allergen field was conducted for 2 seasons. After baseline season, subjects (n = 181) were randomized received 3...
Not available.
Hymenoptera venom (HV) is injected into the skin during a sting by such as bees or wasps. Some components of HV are potential allergens and can cause large local and/or systemic allergic reactions (SAR) in sensitized individuals. During their lifetime, ~ 3% general population will develop SAR following sting. This guideline presents diagnostic therapeutic approach to stings. Symptomatic therapy usually required after severe reaction, but specific diagnosis allergen immunotherapy (AIT) with...
Abstract Background Chronic urticaria ( CU ) is a frequent skin disease characterized by relapsing appearance of pruritic hives. While clinical symptoms are due to the release histamine cutaneous mast cells, underlying pathophysiology still unknown. However, previous studies indicate that basophils might be relevance. Besides, occurrence autoantibodies against IgE or its receptor, Fcε RI , and therapeutic efficacy anti‐IgE antibodies imply IgE‐mediated mechanisms also play an important role...
This guideline on diagnostic procedures for suspected beta-lactam antibiotic (BLA) hypersensitivity was written by the German and Austrian professional associations allergology, Paul-Ehrlich Society Chemotherapy in a consensus procedure according to criteria of Association Scientific Medical Societies. BLA such as penicillins cephalosporins represent drug group that most frequently triggers allergies. However, frequency reports allergy patient histories clearly exceeds number confirmed...
BackgroundWe recently reported that 16 weeks of sublingual immunotherapy (SLIT) with recombinant (r) Mal d 1, but not rBet v significantly improved birch pollen–related apple allergy. Allergen-specific IgE-blocking IgG antibodies have been associated clinical efficacy.ObjectiveWe compared the quantity, quality, and bioactivity SLIT-induced 1-specific in both treatment groups.MethodsPre- post-SLIT sera were assessed for rMal 1–specific ELISA their ability to inhibit allergen–induced...
GA2LEN, the Global Allergy and Asthma European Network, HAE international (HAEi), global umbrella organization for world's hereditary angioedema (HAE) patient groups, have launched their joint ACARE (Angioedema Center of Reference Excellence) program, within GA2LEN's center reference excellence (CORE) initiative. Angioedema is a common, heterogeneous, often debilitating chronic condition frequently challenge physicians affected patients, especially patients suffering from recurrent attacks....
Background IgE antibodies specific for the major birch pollen allergen frequently cross-react with Bet v 1 homologous food proteins, example Cor a in hazelnut and Mal d apple. Specific immunotherapy (BP-SIT) induces IgG4 that inhibit binding to 1. However, information on cross-reactivity of BP-SIT-induced 1-specific allergens is limited. In this study, we investigated kinetics production, cross-reactivity, IgE-blocking activity emerging during conventional BP-SIT whether IgG4-epitopes...
This guideline on diagnostic procedures for suspected beta-lactam antibiotic (BLA) hypersensitivity was written by the German and Austrian professional associations allergology, Paul-Ehrlich Society Chemotherapy in a consensus procedure according to criteria of Association Scientific Medical Societies. BLA such as penicillins cephalosporins represent drug group that most frequently triggers allergies. However, frequency reports allergy patient histories clearly exceeds number confirmed...
For the preventive treatment of 2019 coronavirus disease (COVID-19) an unprecedented global research effort studied safety and efficacy new vaccine platforms that have not been previously used in humans. Less than one year after discovery severe acute respiratory syndrome 2 (SARS-CoV-2) viral sequence, these vaccines were approved for use European Union (EU) as well numerous other countries mass vaccination efforts began. The so far EU mRNA BNT162b2 mRNA-1273 are based on similar lipid-based...
Background Pruritic dermatoses of the elderly often pose a diagnostic and therapeutic challenge. Specifically, prodromal phase bullous pemphigoid (BP) has to be considered in patients with pruritic lesions polymorphic appearance. These conditions frequently do not fulfil all clinical, histological immunopathological criteria for establishing diagnosis BP. Objectives To investigate IgG reactivity against autoantigens BP, BP180 BP230, by enzyme-linked immunosorbent assay, affected various...