A5048191367- Autoimmune Bullous Skin Diseases
- Cutaneous lymphoproliferative disorders research
- Dermatology and Skin Diseases
- Food Allergy and Anaphylaxis Research
- Inflammasome and immune disorders
- Urticaria and Related Conditions
- Allergic Rhinitis and Sensitization
- Contact Dermatitis and Allergies
- Lymphoma Diagnosis and Treatment
- Cutaneous Melanoma Detection and Management
- Drug-Induced Adverse Reactions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Psoriasis: Treatment and Pathogenesis
- Melanoma and MAPK Pathways
- IL-33, ST2, and ILC Pathways
- Immunotherapy and Immune Responses
- Heme Oxygenase-1 and Carbon Monoxide
- Cancer Immunotherapy and Biomarkers
- Nail Diseases and Treatments
- Asthma and respiratory diseases
- Mast cells and histamine
- Immune Cell Function and Interaction
- Fungal Infections and Studies
- Gout, Hyperuricemia, Uric Acid
- Chronic Lymphocytic Leukemia Research
Universitätsklinikum Aachen
2019-2025
RWTH Aachen University
2019-2025
Baylor College of Medicine
2025
University of Tübingen
2014-2023
Centrum für Integrierte Onkologie
2023
University Children's Hospital Tübingen
2011-2021
Hautklinik Heidelberg
2011-2020
University Medical Center
2020
University Hospital and Clinics
2020
University Hospital Heidelberg
2019
Nanoparticles are increasingly used in various fields, including biomedicine and electronics. One application utilizes the opacifying effect of nano-TiO 2 , which is frequently as pigment cosmetics. Although TiO believed to be biologically inert, an emerging literature reports increased incidence respiratory diseases people exposed . Here, we show that nano-SiO but not nano-ZnO, activate NLR pyrin domain containing 3 (Nlrp3) inflammasome, leading IL-1β release addition, induce regulated...
Although the importance of NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome in health and disease is well appreciated, a precise characterization NLRP3 expression yet undetermined. To this purpose, we generated knock-in mouse which Nlrp3 coding sequence was substituted for GFP (enhanced [egfp]) gene. In way, eGFP driven by endogenous regulatory elements study, show that indeed mirrors NLRP3. Interestingly, splenic neutrophils, macrophages, and, particular, monocytes...
Background Hypoxia inducible factor (HIF)-1 is the key transcriptional involved in adaptation process of cells and organisms to hypoxia. Recent findings suggest that HIF-1 plays also a crucial role inflammatory infectious diseases. Methodology/Principal Findings Using patient skin biopsies, cell culture murine infection models, activation was determined by immunohistochemistry, immunoblotting reporter gene assays linked cellular oxygen consumption. The course S. aureus peritonitis upon...
A chronic inflammatory microenvironment favors tumor progression through molecular mechanisms that are still incompletely defined. In inflammation-induced skin cancers, IL-1 receptor- or caspase-1–deficient mice, mice specifically deficient for the inflammasome adaptor protein ASC (apoptosis-associated speck-like containing a CARD) in myeloid cells, had reduced incidence, pointing to role signaling and activation development. However, fully were not protected, keratinocytes developed more...
Abstract Background The production of IgE molecules specific to the carbohydrate galactose‐α‐1,3‐galactose (alpha‐gal) is known induce delayed anaphylaxis against mammalian meat. Tick bites constitute primary sensitization source, as ticks transfer alpha‐gal in their saliva a host during bite. reported prevalence alpha‐gal‐specific (alpha‐gal‐ sIgE ) positivity varies between different populations from diverse geographic regions. Objective To investigate alpha‐gal‐ population forest service...
Most data on chronic spontaneous urticaria (CSU) originate from highly selected patient populations treated at specialized centres. Little is known about CSU characteristics and the burden of in routine clinical practice. AWARE (A World-wide Antihistamine-Refractory Evaluation) an ongoing global study designed to assess real-life setting.To describe baseline first 1539 German patients with H1-antihistamine-refractory CSU.This prospective non-interventional included (18-75 years) a diagnosis...
The detection of drug-specific activation T cells in the lymphocyte transformation test (LTT) is mainly based on cell proliferation or cytokine secretion. However, LTT presents with a varying sensitivity and specificity. aim our study was to analyse genome wide gene expression PBMC identify drug allergy-specific regulation patterns. Additionally, differences related allergy-inducing type allergy (immediate/delayed) were investigated. Blood samples from 40 patients different drugs...
Background— Bartonella species are the only known bacterial pathogens causing vasculoproliferative disorders in humans (bacillary angiomatosis [BA]). Cellular and pathogenetic mechanisms underlying induction of BA largely unknown. Methods Results— Activation hypoxia-inducible factor-1 (HIF-1), key transcription factor involved angiogenesis, was detected henselae –infected host cells vitro by immunofluorescence, Western blotting, electrophoretic mobility shift, reporter gene assays...
Abstract Pemphigus vulgaris is a life-threatening blistering skin disease caused by autoantibodies destabilizing desmosomal adhesion. Current therapies focus on suppression of autoantibody formation and thus treatments directly stabilizing keratinocyte adhesion would fulfill an unmet medical need. We here demonstrate that apremilast, phosphodiesterase 4 inhibitor used in psoriasis, prevents pemphigus vulgaris. Apremilast abrogates autoantibody-induced loss cohesion ex-vivo human epidermis,...
Immune checkpoint blockade has revolutionized cancer treatment. Patients developing immune mediated adverse events, such as colitis, appear to particularly benefit from inhibition. Yet, the contributing mechanisms are largely unknown. We identified a systemic LPS signature in melanoma patients with colitis following anti-cytotoxic T lymphocyte-associated antigen 4 (anti-CTLA-4) inhibitor treatment and hypothesized that intestinal microbiota-derived contributes therapeutic efficacy. Because...