Aim of the study was to compare short-term effects oxygen therapy via a high-flow nasal cannula (HFNC) on functional and subjective respiratory parameters in patients with acute hypoxic failure comparison non-invasive ventilation (NIV) standard treatment Venturi mask.Fourteen were treated HFNC (FiO2 0.6, gas flow 55 l/min), NIV PEEP 5 cm H2O Hg, tidal volume 6-8 ml/kg ideal body weight,) mask 15 l/min,) randomized order for 30 min each. Data collection included objective circulatory as well...

Abstract Background The production of IgE molecules specific to the carbohydrate galactose‐α‐1,3‐galactose (alpha‐gal) is known induce delayed anaphylaxis against mammalian meat. Tick bites constitute primary sensitization source, as ticks transfer alpha‐gal in their saliva a host during bite. reported prevalence alpha‐gal‐specific (alpha‐gal‐ sIgE ) positivity varies between different populations from diverse geographic regions. Objective To investigate alpha‐gal‐ population forest service...

Aim Motor deterioration is a key feature in metachromatic leukodystrophy (MLD). The lack of data about its natural course impedes evaluation therapeutic interventions. This study aimed to provide motor decline MLD. Method Fifty‐nine patients (27 males, 32 females) with MLD (21 late‐infantile and 38 juvenile MLD) were recruited within nationwide survey (the German LEUKONET). Median (range) age at onset was 17 months (9–27) for the group 6 years 2 (2y 11mo–14y) Gross function assessed using...

To analyze the outcome of hepatoblastoma (HB) patients presenting with post treatment extent disease (POST-TEXT) stages III and IV after neoadjuvant chemotherapy.Primary liver transplantation has been advocated as surgical for children HB involving 3 or 4 sectors at diagnosis. However, in some cases, tumors seem resectable chemotherapy through aggressive use nontransplant procedures.Data 27 were reviewed, undergoing extended resection POST-TEXT between 1992 2015. Median follow-up was 58...

Point-of-care testing (POCT) of coagulation has been proven to be great value in accelerating emergency treatment. Specific POCT for direct oral anticoagulants (DOAC) is not available, but the effects DOAC on established have described. We aimed determine diagnostic accuracy Hemochron® Signature qualitatively rule out relevant concentrations apixaban, rivaroxaban, and dabigatran real-life patients. enrolled 68 patients receiving or obtained blood samples at six pre-specified time points....

Specific coagulation assays for non-vitamin K antagonist oral anticoagulants (NOAC) are relatively slow and often lack availability. Although specific point-of-care tests (POCT) currently not available, NOAC known to affect established POCT. This study aimed at determining the diagnostic accuracy of CoaguChek POCT rule out relevant concentrations rivaroxaban, apixaban, dabigatran in real-life patients.We consecutively enrolled 60 ischemic stroke patients newly started on treatment obtained...

Aim Motor deterioration is a key feature of late infantile and juvenile metachromatic leucodystrophy (MLD). Assessment the disease course implies need for standardized description motor decline. The aim this study was to establish classification system gross function in MLD assess its interrater reliability. Method Gross Function Classification (GMFC-MLD) modelled analogous System cerebral palsy. data from 59 individuals (27 male; 32 female) with (21 infantile; 38 juvenile) born between 1970...

Severe congenital GH deficiency (GHD) of the newborn is a rare disease, which can cause life-threatening hypoglycemias beginning in first week life. Reviews and consensus papers on diagnosis GHD repeatedly state lack practical evidence-based approach to newborn.Here we provide for time sound reference values diagnostic cutoff levels newborns at age between d 3 5.GH was measured eluate from 314 filter screening test performed our university hospital by using highly sensitive human GH-ELISA....

Thoracoscopic approach for repair of esophageal atresia (EA) and tracheo-esophageal fistula (TEF) has become a standard procedure in many pediatric surgical centers. surgery newborn is demanding from both the surgeon patient. The potential benefits are still discussed by neonatologists, intensive care physicians, also parents. aim our investigation was to clearly define perioperative outcome complication rates children undergoing thoracoscopic versus open EA TEF repair.We reviewed records 68...

The distinction between constitutional delay of growth and puberty (CDGP) isolated hypogonadotropic hypogonadism (IHH) in males with delayed is difficult but important for timely treatment. We assessed the accuracy GnRH agonist test (triptorelin 0·1 mg) comparison inhibin B alone or combination basal LH diagnosis IHH.Ninety-seven prepubertal aged 13·7-17·5 year, testicular volumes ≤4 ml, were examined every 6 months. CDGP was defined by a volume ≥8 ml after 18 months, IHH <5 24 months...

Abstract Aims To assess the incidence and trend in of Type 1 diabetes (T1DM) children adolescents &lt; 15 years age Baden‐Württemberg (BW), Germany. Methods BW is Germany's third largest federal state. All 31 paediatric departments one centre participated study. Case registration was done according to EURODIAB criteria. The degree ascertainment 97.2%. Results From 1987 2003, age‐ sex‐standardized rate 14.1/100 000 per year [95% confidence interval (CI) 13.7, 14.6, n = 4017]. estimated annual...

Minimally invasive procedures are increasingly important in pediatric urology. However, experience is still limited with minimally operations on the upper urinary tract infants. We analyzed 3 (pyeloplasty, heminephroureterectomy and nephrectomy) children younger than 1 year.We 67 (mean +/- SD age 5.1 2.9 months) undergoing pyeloplasty 26 patients (group 1), 18 2) or nephrectomy 23 3) regard to technical aspects, surgical outcome complications. Preoperative postoperative ultrasound...

Objective: To analyze the outcome of Wilms' tumor patients with primary lung metastases. Summary background data: Radiotherapy and/or surgery are used for local control pulmonary A widely accepted treatment standardization is still lacking. Methods: Data 210 and metastases from collaborative multicenter trials SIOP 93-01/GPOH 2001/GPOH German Society Pediatric Oncology Hematology were reviewed. Analyses included patient data, characteristics, treatment, possible prognostic factors. Results:...

Objective Laparoscopic cholecystectomy (LC) remains one of the most frequent surgical therapies for symptomatic gallstone disorders. Prolonged operative time is frequently associated with increased complication rates. The aim this study was to identify risk factors prolonged times minimize perioperative morbidity and optimize clinical management. Methods A total 677 consecutive patients underwent LC. exclusion criteria were conversion an open procedure, intraoperative cholangiography, liver...

Purpose: The aim of this study was to evaluate outcome patients with congenital diaphragmatic hernia (CDH) undergoing open versus minimally invasive surgery. Subjects and Methods: Patient records 33 children surgery for CDH between March 2002 September 2008 were reviewed. data compared regarding operating time, intraoperative maximum CO2 partial pressure (pCO2max) values, postoperative ventilation complications, recurrences. Results: Median age at time operation 4 days (range, 0–1017 days),...

To study the lengths and diameters of aortic segments in healthy diseased aortas to assess role elongation Type A dissection (TAD) prediction.Ectasia aneurysm were defined by ascending aorta 45-54 mm ≥55 mm, respectively. Computed tomography angiography studies 256 healthy, 102 ectasia, 38 aneurysm, 17 pre-TAD 166 TAD analysed using curved multiplanar reformats.The groups structurally equal. The diameter was 35 control group larger (P < 0.001) (43 mm) (56 groups. length from annulus...

We measured aortic dimensions, particularly length parameters, using 3D imaging with the aim of refining risk-morphology for Stanford type A dissection (TAD).Computer tomography angiography studies were analysed curved multiplanar reformats. At defined landmarks, diameters and lengths segments recorded. Three groups compared retrospectively: patients actually suffering from a TAD (TAD-group; n = 150), before (preTAD-group 15) healthy control group ( 215). Receiver operating characteristic...

Background and Purpose— In patients receiving direct oral anticoagulants (DOACs), emergency treatment like thrombolysis for acute ischemic stroke is complicated by insufficient availability of DOAC-specific coagulation tests. Conflicting recommendations have been published concerning the use global assays ruling out relevant DOAC-induced anticoagulation. Methods— Four hundred eighty-one samples from 96 DOAC-treated were tested using prothrombin time (PT), activated partial thromboplastin...

Introduction Aim of this study was to reduce blood loss caused by diagnostic sampling and minimize the development anemia in a high-risk group mechanically ventilated medical intensive care patients. We therefore implemented "blood-saving bundle" (BSB) combining closed-loop arterial system, smaller tubes, reduced frequency drawings, sample numbers. Methods The included all patients from our ICU who were for more than 72 hours. Exclusion criteria were: acute or chronic on admission, bleeding...

BackgroundIndications for endoscopic retrograde cholangiopancreatography (ERCP) in children differ from adults. Paucity of data and concerns about potential lower effectiveness more side effects limit its use even high volume centers. We retrospectively analyzed indications, success rates, limitations, ERCPs <18 years. MethodsFrom January 2012 to March 2015, 54 were performed 31 (median age 11 (0–17) years; median weight 22 (3.3–142.7) kg) with suspected choledocholithiasis (n = 13...