A5043235523- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Cardiac Imaging and Diagnostics
- Helicobacter pylori-related gastroenterology studies
- Anesthesia and Sedative Agents
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Cell Adhesion Molecules Research
- Gastrointestinal disorders and treatments
- Cerebrovascular and Carotid Artery Diseases
- Cardiac electrophysiology and arrhythmias
- Immune Response and Inflammation
- Cardiovascular Function and Risk Factors
- Immune Cell Function and Interaction
- Cardiac Arrhythmias and Treatments
- Anesthesia and Neurotoxicity Research
- RNA Interference and Gene Delivery
- Liver Disease Diagnosis and Treatment
- T-cell and B-cell Immunology
- Respiratory Support and Mechanisms
- Metabolism and Genetic Disorders
- Coronary Interventions and Diagnostics
- Immunotherapy and Immune Responses
- Nitric Oxide and Endothelin Effects
Kyoto University
2009-2024
Tokyo Teishin Hospital
2006-2023
Nagoya Ekisaikai Hospital
2021
Kyowa Kirin (Japan)
2001-2019
Tokyo Rinkai Hospital
2019
Nippon Medical School Hospital
2013-2016
Nippon Medical School
1995-2016
Sakai Municipal Hospital
2014
Nihon University
2014
Kagoshima University
1994-2009
A combination of genetic and environmental factors can cause autoimmune disease in animals. SKG mice, which are genetically prone to develop arthritis, fail the under a microbially clean condition, despite active thymic production arthritogenic T cells their persistence periphery. However, environment, single intraperitoneal injection zymosan, crude fungal beta-glucan, or purified beta-glucans such as curdlan laminarin trigger severe chronic arthritis but only transient normal mice. Blockade...
Background and Study Aims: One of the major complications endoscopic mucosal resection (EMR) for gastrointestinal tumors is perforation, most effective way preventing perforation to elevate lesion sufficiently by injection fluid into submucosa. Materials Methods: In order compare lesion-lifting properties several different solutions, 1 ml each following solutions was injected submucosa resected porcine stomach: normal saline, 3.75 % NaCl, 20 dextrose water, 10 glycerin with 0.9 NaCl plus 5...
Background: Although the strip biopsy method and aspiration are popular endoscopic mucosal resection techniques for its convenience reliability, they have limitations in resectable tumor size location. Endoscopic submucosal dissection using diathermic needle knife or insulated‐tip been introduced to overcome this disadvantage, but high risks bleeding perforation. Therefore, we developed a new technique tip of an electrosurgical snare (thin type) assessed efficacy. Methods: Fifty‐nine lesions...
C-reactive protein (CRP), a predictor of cardiovascular events, localizes in atherosclerotic arteries and exerts proinflammatory effects on vascular cells. Reactive oxygen species (ROS) have been implicated atherogenesis plaque instability.Expressional pattern CRP directional coronary atherectomy specimens from 39 patients was examined. Characteristics histological instability higher levels serum fibrinogen were associated with the immunoreactivity. In situ hybridization revealed presence...
Background and study aims: Endoscopic submucosal dissection (ESD) is a novel technique used for the treatment of gastrointestinal neoplasia. One its major limitations, however, complication perforation. Patients methods: We included in our all cases perforation that occurred during ESD procedures epithelial neoplasia between February 2000 2005. Clinical outcomes after were investigated. Results: Perforation was experienced at 27 lesions patients (four esophagus, fourteen stomach, seven...
We previously demonstrated that cinnamon extract (CE) ameliorates type 1 diabetes induced by streptozotocin in rats through the up-regulation of glucose transporter 4 (GLUT4) translocation both muscle and adipose tissues. This present study was aimed at clarifying detailed mechanism(s) with which CE increases uptake vivo cell culture systems using 3T3-L1 adipocytes C2C12 myotubes vitro. Specific inhibitors key enzymes insulin signaling AMP-activated protein kinase (AMPK) pathways, as well...
Objective— NADH/NADPH oxidase is an important source of reactive oxygen species (ROS) in the vasculature. Recently, we demonstrated that p22 phox , essential component this oxidase, was expressed human coronary arteries and its expression enhanced with progression atherosclerosis. The present study undertaken to investigate functional importance pathogenesis artery disease. For aim, distribution oxidized low density lipoprotein (LDL), generation ROS directional atherectomy (DCA) specimens...
The technique of endoscopic submucosal dissection (ESD) has recently been developed for en-bloc resection gastric tumors. For oncological reasons and in order to improve the patients' quality life, it may be desirable use same rectal neoplasia.Thirty-five consecutive patients with neoplasia who had a preoperative diagnosis large intraepithelial neoplasias fibrosis or located on folds were enrolled. ESD was carried out previously described stomach, some modifications. efficacy, complications,...
Sodium hyaluronate (SH) is a promising submucosal injection solution during endoscopic mucosal resection, but its high cost an obstacle to more widespread use. The aim of this study was identify appropriate low-cost SH by varying the molecular weight and mixing various solutions with it.The viscoelasticity first measured. concentrations two 1 % preparations different weights (800 kDa 1900 kDa) were adjusted 0.5 %, 0.25 0.125 using 0.9 %/3.75 normal saline (NS), 5 %/20 dextrose water (DW),...
Background: Due to the remarkable progress of endoscopic resection techniques, submucosal dissection (ESD) has been widely performed for larger mucosal tumors that would result in large artificial ulcers. The healing process peptic ulcers previously studied detail; however, no precise investigation after ESD reported. To confirm validity treatment from aspect wound healing, we aimed clarify gastric ESD. Methods: Seventy patients with treated by were enrolled. size, location and time scar...
Background and Study Aim: We have previously reported that gastric ulcers artificially created by endoscopic submucosal dissection (ESD) would heal within 8 weeks regardless of size location. The details the healing process remain unclear, we aimed to clarify mechanism histopathological investigation. Patients Methods: 21 post-ESD were examined histopathologically, using surgically resected specimens from patients who had subsequently undergone gastrectomy due invasion and/or lymphovascular...
Delayed post-hypoxic leukoencephalopathy (DPHL) is a poorly recognized syndrome characterized by neuropsychiatric symptoms following recovery from an acute hypoxic episode. Although most cases are related to carbon monoxide poisoning, some have been linked excessive opioid use. Opioid intoxication has recently become known for manifesting the characteristic imaging findings involving cerebellar, hippocampal, and basal nuclei transient edema with restricted diffusion (CHANTER) syndrome....
Adult-onset type II citrullinemia is characterized by which deficiency of argininosuccinate synthetase (ASS) protein found specifically in the liver patients. Our recent study using differential messenger RNA (mRNA) display showed that expression human pancreatic secretory trypsin inhibitor (hPSTI) mRNA increases significantly all patients tested. In present work, we concentration hPSTI was higher than controls. Because it well known PSTI a and because serum has been proposed as marker...
ABSTRACT Capsule-forming Klebsiella pneumoniae K1 caused primary liver abscess in two household members of a family. The causative isolates had identical pulsed-field gel electrophoresis patterns and were determined to be sequence type 23. An additional member the family was found carry same strain without clinical manifestation.
To investigate the clinical significance of carbohydrate antigen 125 (CA125), an related to ovarian cancer, in patients with pericardial effusion, we examined relationship between serum levels CA125 and presence or severity effusion. Fifty-seven (25 heart failure. 22 metastasis, 4 hypothyroidism, renal failure, 2 other diseases) whom effusion was confirmed by echocardiography autopsy, were used as subjects. Thirty-seven these (65%) tested positive for serum. Of these, no significant...
SUMMARY Most of the leucocytes infiltrating rheumatoid synovial fluid (SF) are neutrophils capable producing a variety inflammatory mediators known to contribute significantly disease process during active RA. In present study, we investigated contribution made by SF elevated levels vascular endothelial growth factor (VEGF) seen in SF. Rheumatoid were found contain larger amounts both VEGF protein and its mRNA than peripheral blood from either RA patients or healthy controls. Levels...
Abstract Recently, we have identified human cord blood (CB)-derived CD34-negative (CD34−) severe combined immunodeficiency (SCID)-repopulating cells (SRCs) using the intra-bone marrow injection (IBMI) method (Blood 2003;101:2924). In contrast to murine CD34− Kit+Sca-1+Lineage− (KSL) cells, CB-derived Lin−CD34− did not express detectable levels of c-kit by flow cytometry. this study, investigated function flt3 in our SRCs. Both CD34+flt3+/− showed SRC activity. cell fraction, only CD34−flt3−...
Neutrophils are the predominant leukocyte population in acute inflammation. Granulomatous inflammation such as tuberculosis is a specific type of chronic characterized by accumulation macrophages. To clarify mechanism cellular recruitment inflammation, expression chemokines, interleukin-8 and monocyte chemotactic activating factor (MCAF)/monocyte chemoattractant protein 1 (MCP-1), was examined human blood monocytes response to lipopolysaccharide Escherichia coli, which could induce or...
Small interfering of RNA (siRNA) technology has the potential to be a next-generation therapy. However, naked siRNA does not have high transfection efficiency and is rapidly degraded after systemic injection, so an appropriate drug delivery system (DDS) required for clinical use. Several systems been assessed, clinically focusing on hepatocyte or cancer tissue using siRNA. targeting immune cells still challenging, new DDS required. In this study, we prepared lipid nanoparticles (LNP)...