A5031325837- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Immune Cell Function and Interaction
- Physics of Superconductivity and Magnetism
- Mesenchymal stem cell research
- Acute Lymphoblastic Leukemia research
- Magnetic properties of thin films
- Polyomavirus and related diseases
- Platelet Disorders and Treatments
- Blood transfusion and management
- Blood groups and transfusion
- T-cell and B-cell Immunology
- Cytomegalovirus and herpesvirus research
- Erythrocyte Function and Pathophysiology
- Magnetic and transport properties of perovskites and related materials
- Epilepsy research and treatment
- Blood disorders and treatments
- Advanced Condensed Matter Physics
- Chronic Myeloid Leukemia Treatments
- Electronic and Structural Properties of Oxides
- Immunodeficiency and Autoimmune Disorders
- Immunotherapy and Immune Responses
- Superconducting Materials and Applications
- Mast cells and histamine
- RNA Interference and Gene Delivery
Japanese Red Cross Society, Japan
2016-2025
Central Research Institute of Electric Power Industry
2024
University of Hyogo
2024
Kyoto University
2016
RIKEN
2005-2015
Boehringer Ingelheim (Japan)
2013
Toyohashi University of Technology
2013
Niigata University
1997-2012
Tohoku University
2008-2012
Osaka Red Cross Hospital
2007-2011
Allografts of retinal pigment epithelial (RPE) cells have been considered for the treatment ocular diseases. We recently started transplantation induced pluripotent stem cell (iPSC)-derived RPE patients with age-related macular degeneration (autogenic grafts). However, there are at least two problems this approach: (1) high cost, and (2) uselessness acute patients. To resolve these issues, we established from iPSCs in HLA homozygote donors. In vitro, human T directly recognized allogeneic...
Background and Purpose- Bone marrow mononuclear cells (BM-MNCs) are a rich source of hematopoietic stem have been widely used in experimental therapies for patients with ischemic diseases. Activation angiogenesis is believed to be one major BM-MNC mode actions, but the essential mechanism by which BM-MNCs activate hitherto elusive. The objective this study reveal how angiogenesis. Methods- We evaluated effect direct cell-cell interaction between endothelial cell on uptake VEGF (vascular...
Summary. The Wilms' tumour gene, WT1, is expressed at high levels in leukaemia cells and plays an important role leukaemogenesis. WT1 also human normal CD34 + bone marrow (BM) about 100 times lower than cells. To identify characterize WT1‐expressing BM cells, they were sorted into single analysed for expression using two kinds of single‐cell reverse transcriptase polymerase chain reaction (RT–PCR) methods. Using the semiquantitative polyA‐PCR sequence‐specific (SS)‐PCR method, was detected...
An Si on double heterostructure material for integrated circuits has been developed. The epitaxial layer was grown by using an open‐tube vapor phase transport technique. electron Hall mobility and the defect density of active epitaxially were , respectively, when thickness 8 μm doping concentration . growth conditions layers characteristics are presented.
Allogeneic hematopoietic cell transplantation (HCT) is a potentially curative post-remission therapy for adult patients with acute myeloid leukemia (AML) in complete remission (CR). The availability of alternative human leukocyte antigen (HLA)-mismatched donors, such as cord blood and haploidentical related could allow to receive allogeneic HCT who are without an HLA-matched sibling or unrelated donor. use these donors preferable advanced disease due the rapid availability. However,...
Abstract We have shown previously that transplanted bone marrow mononuclear cells (BM-MNC), which are a cell fraction rich in hematopoietic stem cells, can activate cerebral endothelial via gap junction-mediated cell-cell interaction. In the present study, we investigated such interaction between mesenchymal (MSC) and cells. contrast to BM-MNC, for MSC observed suppression of vascular growth factor uptake into transfer glucose from vitro. The small molecule endothelium was subsequently...
Abstract Unrelated cord blood transplantation (CBT) is an alternative curative option for adult patients with acute myeloid leukemia (AML) who need allogeneic hematopoietic cell (HCT) but lack HLA-matched related or unrelated donor. However, large-scale data are lacking on CBT outcomes unselected AML. To investigate the trends of survival and engraftment after over past 22 years, we retrospectively evaluated AML in Japan according to time period (1998–2007 vs 2008–2013 2014–2019). A total...
Abstract Purpose: The anti-leukemic activity of allogeneic hematopoietic cell transplantation (HCT) depends on both the intensity conditioning regimen and strength graft-versus-leukemia (GVL) effect. However, it is unclear whether sensitivity GVL effects differs between donor type graft source. Experimental Design: We retrospectively evaluated effect acute chronic graft-versus-host disease (GVHD) transplant outcomes for adults with leukemia (n = 6,548) 2007 2017 using a Japanese database. In...
Allogeneic haematopoietic stem cell transplantation (HSCT) is a potentially curative treatment for some patients with acute myeloid leukaemia (AML) who are refractory to chemotherapy. Cord blood (CBT) reasonable option in such cases because of its rapid availability. Recently, growing number human leucocyte antigen (HLA)-haploidentical related donor HSCTs (haplo-HSCTs) have been performed, although effectiveness remains undetermined. Using the Japanese nationwide registry data, we identified...
Novel Sr source materials for metalorganic chemical vapor deposition (MOCVD) of SrTiO 3 have been developed. They were synthesized by adding amine, triethylenetetramine (trien) or tetraethylenepentamine (tetraen), to bis-dipivaloylmethanato strontium ( Sr(DPM) 2 , strontium-bis-2,2,6,6-tetramethyl-3,5-heptanedionate). The new sources, -trien and -tetraen a low melting point (43–75° C), are liquid in phase when they vaporized at 120–130° C. thin films prepared on Pt/Ta/ SiO /Si substrates...
Abstract Recently, we have identified human cord blood (CB)-derived CD34-negative (CD34−) severe combined immunodeficiency (SCID)-repopulating cells (SRCs) using the intra-bone marrow injection (IBMI) method (Blood 2003;101:2924). In contrast to murine CD34− Kit+Sca-1+Lineage− (KSL) cells, CB-derived Lin−CD34− did not express detectable levels of c-kit by flow cytometry. this study, investigated function flt3 in our SRCs. Both CD34+flt3+/− showed SRC activity. cell fraction, only CD34−flt3−...
The possibility that HLA mismatches could reduce relapse after alternative HLA-mismatched allogeneic hematopoietic cell transplantation (HCT) is an attractive concept for treating acute myeloid leukemia (AML). However, it remains unclear whether the prognostic effect of graft-versus-host disease (GVHD) on survival differs between recipients single-unit cord blood (CBT) and haploidentical HCT using post-transplantation cyclophosphamide (PTCy-haplo-HCT) AML. objective this retrospective study...
The efficacy of hematopoietic stem cell (HSC) therapy for cerebral infarction has been previously demonstrated. However, the lack response in some patients hindered its widespread use. To establish HSC as a standard treatment, it is important to examine causes non-responsiveness. In this study, we aimed identify specifications transplanted cells based on their therapeutic mechanisms predict treatment success. We found that activates injured endothelial via gap junctions because adhesion...
Introduction: Among pathogen inactivation methods for blood products, an ultraviolet C (UVC) irradiation has been attracting attention. We previously reported that 265 nm UV-LED (UVC-LED) effectively prevents bacterial infection. However, the effect of UVC-LED on plasma was not considered. This study aimed to explore effects high-dose irradiation, required viral inactivation, hemostatic potential. Methods: After with 60 min, activities coagulation factors and inhibitors von Willebrand factor...