A5065367171- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- Renal and related cancers
- T-cell and B-cell Immunology
- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Polyomavirus and related diseases
- Cytomegalovirus and herpesvirus research
- Renal Transplantation Outcomes and Treatments
- Childhood Cancer Survivors' Quality of Life
- Chronic Myeloid Leukemia Treatments
- Glycosylation and Glycoproteins Research
- RNA Interference and Gene Delivery
- Mesenchymal stem cell research
- Inflammasome and immune disorders
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Mechanical Failure Analysis and Simulation
- Autophagy in Disease and Therapy
- T-cell and Retrovirus Studies
- Prenatal Screening and Diagnostics
- Transplantation: Methods and Outcomes
Hyogo University
2022-2024
Hyogo Medical University
2014-2023
University of Michigan
2012-2013
Michigan Center for Translational Pathology
2012-2013
Osaka Minami Medical Center
2003-2007
Osaka University
1996-2006
Nippon Life Hospital
2002
Sakai Municipal Hospital
2002
Nippon Medical School
2002
Kyoto Prefectural University of Medicine
1997
To determine the role of Wilms' tumor gene WT1 in tumorigenesis solid tumors, expression was examined 34 cell lines (four gastric cancer lines, five colon 15 lung four breast one germ line, two ovarian uterine thyroid and hepatocellular carcinoma line) by means quantitative reverse transcriptase-polymerase chain reaction. detected three all 12 line. Therefore, examined, 28 (82%) expressed WT1. Three expressing (gastric line AZ-521, OS3, TYK-nu) were further analyzed for mutations and/or...
Abstract Expression of the Wilms' tumor gene WT1 in de novo lung cancer was examined using quantitative real‐time RT‐PCR and immunohistochemistry. Overexpression detected by 54/56 (96%) non‐small cell cancers confirmed detection protein with an anti‐WT1 antibody. also demonstrated 5/6 (83%) small Furthermore, when for mutations direct sequencing genomic DNA 7 cancers, no were found. These results suggest that nonmutated, wild‐type plays important role tumorigenesis may provide us rationale...
Summary. The Wilms' tumour gene, WT1, is expressed at high levels in leukaemia cells and plays an important role leukaemogenesis. WT1 also human normal CD34 + bone marrow (BM) about 100 times lower than cells. To identify characterize WT1‐expressing BM cells, they were sorted into single analysed for expression using two kinds of single‐cell reverse transcriptase polymerase chain reaction (RT–PCR) methods. Using the semiquantitative polyA‐PCR sequence‐specific (SS)‐PCR method, was detected...
This prospective, multicenter phase I/II study of unmanipulated HLA-haploidentical reduced-intensity stem cell transplantation using a low dose anti-T lymphocyte globulin (ATG) and steroid was conducted in 5 institutions Japan. Thirty-four patients with hematologic malignancies who were an advanced stage or at high risk relapse the time enrolled. Among them, 7 underwent as second because after previous allogeneic transplantation. The conditioning regimen consisted fludarabine, busulfan, ATG...
MicroRNAs (miRs) have emerged as critical modulators of immune responses, but little is known about their transcriptional regulation and tissue specificity. miR-142 specifically expressed in hematopoietic tissues plays an important role regulating immunity. In this study we identified the key elements for its impact on TLR4-mediated expression IL-6. The PU.1, C/EBPβ, Runx1 transcription factor binding sites are conserved constitutively occupied by respective factors gene promoter only cells....
The role of negative regulators or suppressors the damage-associated molecular pattern-mediated (DAMP-mediated) stimulation innate immune responses is being increasingly appreciated. However, presence and function DAMP-mediated effects on T cells, whether they can be targeted to mitigate cell-dependent immunopathology remain unknown. Sialic acid-binding immunoglobulin-like lectin G (Siglec-G) a regulator in but its cell-autonomous Utilizing loss-of-function-based (genetic knockout)...
Summary Monoclonal antibody (mAb) drugs are desirable for the improvement of multiple myeloma (MM) treatment. In this study, we found first time that CD48 was highly expressed on MM plasma cells. 22 out 24 patients, more than 90% cells at significantly higher levels it normal lymphocytes and monocytes. only weakly some CD34 + haematopoietic stem/progenitor cells, not erythrocytes or platelets. We next examined whether could serve as a target antigen mAb therapy against MM. A newly generated...