A5047539527- Cleft Lip and Palate Research
- Synthesis and Properties of Aromatic Compounds
- Luminescence and Fluorescent Materials
- Craniofacial Disorders and Treatments
- Renal and related cancers
- Photoreceptor and optogenetics research
- Supramolecular Chemistry and Complexes
- Supramolecular Self-Assembly in Materials
- Heat shock proteins research
- Tracheal and airway disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Immune Cell Function and Interaction
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Molecular spectroscopy and chirality
- Nitric Oxide and Endothelin Effects
- Malaria Research and Control
- Crystallography and molecular interactions
- Tumors and Oncological Cases
- Oral and Maxillofacial Pathology
- Vector-borne infectious diseases
- Thyroid Cancer Diagnosis and Treatment
- dental development and anomalies
- Research on Leishmaniasis Studies
- Toxoplasma gondii Research Studies
- Cancer-related molecular mechanisms research
University of Iowa
2008-2023
Okinawa Institute of Science and Technology Graduate University
2015-2021
Tokyo Dental College
2005-2020
Daiichi Sankyo (United States)
2019
Toho University Omori Medical Center
2018
Toho University
2018
Eureka Therapeutics (United States)
2016
Eindhoven University of Technology
2011-2015
Nihon University
2010-2015
Nara Institute of Science and Technology
2008-2013
Abstract Minimally invasive intervention strategies after myocardial infarction use state‐of‐the‐art catheter systems that are able to combine mapping of the infarcted area with precise, local injection drugs. To this end, delivery drugs not immediately pumped out heart is still challenging, and requires a carrier matrix in solution state can be injected through long catheter, instantaneously gelates at site injection. address unmet need, pH‐switchable supramolecular hydrogel developed. The...
Abstract Purpose: The majority of tumor-specific antigens are intracellular and/or secreted and therefore inaccessible by conventional chimeric antigen receptor (CAR) T-cell therapy. Given that all intracellular/secreted proteins processed into peptides presented class I MHC on the surface tumor cells, we used alpha-fetoprotein (AFP), a specific liver cancer marker, as an example to determine whether peptide–MHC complexes can be targets for CAR therapy against solid tumors. Experimental...
The only approved pharmacological approach for the symptomatic treatment of Alzheimer's disease in Japan is use a cholinesterase inhibitor, donepezil hydrochloride. Recent vivo and vitro studies raise possibility that inhibitors can slow progression disease. purpose present study was to determine whether has neuroprotective effect by using rate hippocampal atrophy as surrogate marker progression.In prospective cohort study, 54 patients with who received 93 control never anti-Alzheimer drugs...
Abstract Expression of the Wilms' tumor gene WT1 in de novo lung cancer was examined using quantitative real‐time RT‐PCR and immunohistochemistry. Overexpression detected by 54/56 (96%) non‐small cell cancers confirmed detection protein with an anti‐WT1 antibody. also demonstrated 5/6 (83%) small Furthermore, when for mutations direct sequencing genomic DNA 7 cancers, no were found. These results suggest that nonmutated, wild‐type plays important role tumorigenesis may provide us rationale...
Solvent chirality transfer using (S)- and (R)-limonenes, which are candidates for renewable volatile bioresources (bp 176 °C/760 Torr or bp 94 °C/68 Torr), allowed the successful production of optically active poly[(9,9-di-n-octylfluorenyl-2,7-diyl)-alt-bithiophene] (F8T2) particles with circular dichroism (CD) circularly polarised luminescence (CPL) properties. The were rapidly produced by CD-silent F8T2 aid solvent at 25 °C. present paper demonstrates following: (i) through weak...
Designers are skilled at sketching and prototyping the look of interfaces, but to explore various behaviors (what interface does in response input) typically requires programming using Javascript, ActionScript for Flash, or other languages. In our survey 259 designers, 86% reported that behavior is more difficult prototype than appearance. Often (78% time), designing collaborating with developers, 76% designers communicatin1g developers was Other results include annotations such as arrows...
Mutations in the gene encoding Cu-Zn superoxide dismutase (SOD1) are one of causes familial amyotrophic lateral sclerosis (FALS). Fibrillar inclusions containing SOD1 and that bind amyloid-specific dye thioflavin S have been found neurons transgenic mice expressing mutant SOD1. Therefore, formation amyloid fibrils from human was investigated. When agitated at acidic pH presence low concentrations guanidine or acetonitrile, metalated formed fibrillar material which bound both T Congo red had...
Expression of the Wilms' tumor gene WT1 in primary astrocytic tumors was examined using a quantitative real‐time reverse transcriptase‐polymerase chain reaction (RT‐PCR) or immunohistochemistry. Real‐time RT‐PCR showed that mRNA expressed at various levels all 25 examined. Immunohistochemical analysis protein 5 6 low‐grade (grade l‐ll) and 18 high‐grade ones III‐IV), expression were significantly higher than those ones. not detected normal glial cells contained specimens. Furthermore,...
Circularly polarized luminescence (CPL) of Eu(III) complexes with point- and axis-chiral ligands, [Eu((R/S)-BINAPO)(D-facam)(3)] ((R/S)-BINAPO, (R/S)-2,2'-bis(diphenylphosphoryl)-1,1'-binaphthyl; D-facam, 3-trifluoroacetyl-d-camphor), [Eu(BIPHEPO)(D-facam)(3)] (BIPHEPO, 2,2'-bis(diphenylphosphoryl)-biphenyl), [Eu(TPPO)(2)(D-facam)(3)] (TPPO, triphenylphosphine oxide), [Eu((R)-BINAPO)(hfa)(3)] (hfa, 1,1,1,5,5,5-hexafluoropentane-2,4-dione) are reported. The photophysical properties chiral...
Hereditary hearing loss is one of the most common birth defects, yet majority genes required for audition thought to remain unidentified. Ethylnitrosourea (ENU)-mutagenesis has been a valuable approach generating new animal models deafness and discovering previously unrecognized gene functions. Here we report on characterization ENU-induced mouse mutant (nmf329) that exhibits recessively inherited deafness. We found widespread sensory hair cells in organs nmf329 mice after second week life....
In humans, hereditary inactivation of either p22phox or gp91phox leads to chronic granulomatous disease (CGD), a severe immune disorder characterized by the inability phagocytes produce bacteria-destroying ROS. Heterodimers and proteins constitute superoxide-producing cytochrome core phagocyte NADPH oxidase. this study, we identified nmf333 mouse strain as what believe be first animal model deficiency. Characterization mice revealed that deletion inactivated not only oxidase, but also second...
Circularly polarized (CP) light may play key roles in the migration and delocalization of photoexcited energy optically active macroscopic aggregates chiral chlorophylls surrounded by an aqueous fluid chloroplasts under incoherent unpolarized sunlight. Learning from biosystem, we designed artificial polymer three highly luminescent helical polysilanes, 1-S, 2-S, 2-R (Chart 1). Under specific conditions (molecular weights good-and-poor solvent ratio), 1-S with ∼5 μm organic generated...
Solvent chirality transfer using enantiomeric pairs of limonene and<italic>α</italic>-pinene allowed for the successful production ambidextrous CD-/CPL-active polyfluorene aggregates from achiral polyfluorenes at 25 °C in a few minutes.
N,N′,N′′-Trialkylbenzene-1,3,5-tricarboxamides (BTAs) cooperatively self-assemble into one-dimensional, helical supramolecular polymers in apolar alkane solutions. Previous studies revealed that the position and configuration of methyl group on aliphatic side-chain gives rise to an 'odd–even effect' both shape sign CD-effect. In this study, we elucidate molecular origin odd–even effect by a combination TD-DFT calculations spectroscopic experiments. addition, observed pronounced structure...
In natural systems, highly synergistic non-covalent interactions among biomolecular components exert mesoscopic control over hierarchical assemblies. We herein present a multicomponent self-assembly strategy to tune supramolecular polymer architectures in water using affine and directional ureidopyrimidinone-poly(ethylene glycol)s (UPy-PEG). Using scattering methods oscillatory rheology, we observe the structural mechanical regulation of entangled monofunctional UPy-PEG fibrils by...
We observed the emergence and inversion of chiroptical handedness in three chiroptically silent dialkylpolysilanes during aggregation limonene–methanol–THF tersolvents.
The goal of this project is to evaluate a new auditory cue, which the authors call spearcons, in comparison other cues with aim improving menu navigation.With shrinking displays mobile devices and increasing technology use by visually impaired users, it becomes important improve usability non-graphical user interface (GUI) interfaces such as menus. Using nonspeech sounds called icons (i.e., representative real objects or events) earcons brief musical melody patterns) has been proposed...
Sensory hair cells are essential for hearing and balance. Their development from epithelial precursors has been extensively characterized with respect to transcriptional regulation, but not in terms of posttranscriptional influences. Here we report on the identification functional characterization an alternative-splicing regulator whose inactivation is responsible defective hair-cell development, deafness, impaired balance spontaneous mutant Bronx waltzer (bv) mouse. We used positional...
The roles of gamma delta T, NK and NKT cells in an early stage protective immunity against infection with Leishmania major were investigated. Further, the contribution these innate to expression 65 kDa heat shock protein (HSP65) host macrophages was examined, since we found previously that this prevents apoptotic death infected is a crucial step acquisition various obligate intracellular protozoa including L. major. C57BL/6 DBA/2 mice be resistant on basis parasite burden their regional...
Expression of the Wilms' tumor gene WT1 was examined in 59 cases colorectal adenocarcinoma to examine involvement tumorigenesis. Quantitative real‐time reverse transcription‐polymerase chain reaction (RT‐PCR) showed that mRNA expressed range from 7.2x10 −5 4.9x10 −1 levels ( expression level K562 leukemic cells defined as 1.0) all (100%) 28 examined, and were higher 20 (71%) compared those normal‐appearing mucosal tissues examined. Immunohistochemical analysis using an anti‐WT1 antibody...
Abstract We have developed a novel approach to the preparation of circularly polarized luminescence material from natural polysaccharide host and an achrial polythiophene guest.
The differentiation and functions of osteoclasts are regulated by receptor activator nuclear factor-κB (RANK)/receptor ligand (RANKL) system that stimulates formation. Macrophage colony-stimulating factor (M-CSF) is also essential for osteoclastogenesis. A recent immunocytochemical study reported RANKL/RANK M-CSF/c-fms were localized in the periodontal ligament rat molars during experimental orthodontic tooth movement. present focused on expressions root resorption area movement rats. Forty...