A5103113989- Pain Mechanisms and Treatments
- Diabetes Treatment and Management
- Nerve injury and regeneration
- Botulinum Toxin and Related Neurological Disorders
- Metabolism, Diabetes, and Cancer
- Cancer and Skin Lesions
- Mesenchymal stem cell research
- Diabetes Management and Research
- Pancreatic function and diabetes
- Nonmelanoma Skin Cancer Studies
- Neurological Disorders and Treatments
- Diabetes and associated disorders
- Vascular Tumors and Angiosarcomas
- Advanced Glycation End Products research
- Wound Healing and Treatments
- Diabetic Foot Ulcer Assessment and Management
- Parkinson's Disease Mechanisms and Treatments
- Cardiovascular Function and Risk Factors
- Cutaneous Melanoma Detection and Management
- Diet and metabolism studies
- Angiogenesis and VEGF in Cancer
- Cardiac Imaging and Diagnostics
- Aldose Reductase and Taurine
- Cardiac and Coronary Surgery Techniques
- Tumors and Oncological Cases
Saitama International Medical Center
2024-2025
Committee on Publication Ethics
2022-2024
Aichi Medical University
2014-2024
Toyota Central Research and Development Laboratories (Japan)
2018-2023
Aizawa Hospital
2011-2019
Nagoya University
2005-2015
Yamagata University
2012
Chiayi Chang Gung Memorial Hospital
2012
Wayne State University
2004-2011
Detroit Medical Center
2011
Increased protein kinase C (PKC) activity has been implicated in the pathogenesis of diabetic retinopathy and nephropathy. However, role PKC neuropathy remains unclear. The present study was conducted to compare effect inhibition by a PKC-beta-selective inhibitor, LY333531 (LY), on nerve dysfunction with that an aldose reductase NZ-314 (NZ). Streptozotocin-induced rats were treated or without LY and/or NZ for 4 weeks, motor conduction velocity (MNCV), coefficient variation R-R interval...
OBJECTIVE—Mesenchymal stem cells (MSCs) have been reported to secrete various cytokines that exhibit angiogenic and neurosupportive effects. This study was conducted investigate the effects of MSC transplantation on diabetic polyneuropathy (DPN) in rats. RESEARCH DESIGN AND METHODS—MSCs were isolated from bone marrow adult rats transplanted into hind limb skeletal muscles with an 8-week duration streptozotocin (STZ)-induced diabetes or age-matched normal by unilateral intramuscular...
Abstract The principal causes of death among 45,708 patients with diabetes (29,801 men and 15,907 women) who died in 241 hospitals throughout Japan during 2001–2010 were determined based on a survey the hospital records. Autopsy had been conducted 978 cases. most frequent cause was malignant neoplasia (38.3%), followed by, order descending frequency: infections (17.0%); then vascular diseases (14.9%), including renal failure (3.5%), ischemic heart (4.8%) cerebrovascular (6.6%). Diabetic coma...
We present a case of 32-year-old diabetic woman with Prader-Willi syndrome who developed severe ketoacidosis caused by sodium-glucose cotransporter 2 (SGLT2) inhibitor, novel class antihyperglycemic agents, during strict low-carbohydrate diet. At admission, serum glucose level 191 mg/dL was relatively low, though laboratory evaluations showed ketoacidosis. This is the first report SGLT2 inhibitor. It necessary to not only pay attention when using inhibitor in patients following diet, but...
Diabetic neuropathy is based on the impairment of nerve blood flow and metabolic disorder. Although vasodilating agents anticoagulants improve function symptoms in diabetic neuropathy, more effective treatments are needed. Because endothelial progenitor cells (EPCs) have been identified adult human peripheral blood, many studies shown that transplantation EPCs improves circulation to ischemic tissues. In this study, we demonstrated therapeutic neovascularization using umbilical cord...
OBJECTIVE The therapeutic potential of exendin-4, an agonist the glucagon-like peptide-1 receptor (GLP-1R), on diabetic polyneuropathy (DPN) in streptozotocin (STZ)-induced mice was investigated. RESEARCH DESIGN AND METHODS presence GLP-1R lumbar dorsal root ganglion (DRG) evaluated by immunohistochemical analyses. DRG neurons were dissected from C57BL6/J and cultured with or without Schwann cell–conditioned media absence GLP-1 (7–37) exendin-4. Then neurite outgrowth determined. In...
Cardiac failure is directly affected by left ventricular (LV) dysfunction, and particularly LV systolic dysfunction strongly associated with survival in ESRD patients. The aim of this study was to determine the prognostic value reduced ejection fraction (LVEF) measured at time initiation hemodialysis (HD) incident HD patients.1254 consecutive patients who electively started therapy were screened echocardiography within 1 month after its inception. They divided into five groups according LVEF...
Abstract Aims/Introduction Dental pulp stem cells ( DPSC s) are thought to be an attractive candidate for cell therapy. We recently reported that the transplantation of s increased nerve conduction velocity and blood flow in diabetic rats. In present study, we investigated immunomodulatory effects on peripheral nerves. Materials Methods were isolated from dental Sprague–Dawley rats expanded culture. Eight weeks after streptozotocin injection, transplanted into unilateral hindlimb skeletal...
In 2020, the Japan Diabetes Society (JDS) adopted a sweeping decision to release consensus statements on relevant issues in diabetes management that require updating from time and launched ‘JDS Committee Consensus Statement Development’. These are intended present committee's take based evidence currently available for each of addressed. It is thus hoped practicing diabetologists will never fail consult these provide best practice their respective clinical settings. Of note, while as many...
Relief from painful diabetic neuropathy is an important clinical issue. We have previously shown that the transplantation of cultured endothelial progenitor cells or mesenchymal stem ameliorated in rats. In this study, we investigated whether freshly isolated bone marrow-derived mononuclear (BM-MNCs) alleviates neuropathic pain early stage streptozotocin-induced Two weeks after STZ injection, BM-MNCs vehicle saline were injected into unilateral hind limb muscles. Mechanical hyperalgesia and...
Although previous reports have revealed the therapeutic potential of stem cell transplantation in diabetic polyneuropathy, effects on long-term polyneuropathy not been investigated. In this study, we investigated whether dental pulp cells (DPSCs) ameliorated streptozotocin (STZ)-induced rats. Forty-eight weeks after STZ injection, transplanted DPSCs into unilateral hindlimb skeletal muscles. Four DPSC (i.e., 52 injection) were assessed. STZ-induced rats showed significant reductions sciatic...
Recent studies advocate that omega-3 polyunsaturated fatty acids (ω-3 PUFAs) have direct anti-oxidative and anti-inflammatory effects in the vasculature; however, role of ω-3 PUFAs Schwann cells remains undetermined.Immortalized mouse (IMS32) were incubated with docosahexaenoic acid (DHA) eicosapentaenoic (EPA). The messenger ribonucleic levels several anti-oxidant enzymes (heme oxygenase-1 [Ho-1], nicotinamide adenine dinucleotide [phosphate] H quinone oxidoreductase 1, catalase, superoxide...
Abstract Background Prurigo nodularis (PN), a chronic inflammatory skin condition, adversely affects the quality of life affected individuals. Current treatment options for PN in Japan are limited. Objectives To evaluate optimal dose, efficacy and safety long-term with nemolizumab patients Japan. Methods In 16-week double-blind phase II/III study, aged ≥ 13 years were randomly assigned (1 : 1 1) to 30-mg, 60-mg or placebo groups, concomitant topical corticosteroids, every 4 weeks. The...
Abstract We examined the effects of C‐peptide replacement on unmyelinated fiber function in hind paw, sural nerve C‐fiber morphometry, sciatic neurotrophins, and expression neurotrophic receptors content neuropeptides dorsal root ganglia type 1 diabetic BB/Wor‐rats. from onset diabetes had no effect hyperglycemia, but it significantly prevented progressive thermal hyperalgesia atrophy, degeneration, loss. These findings were associated with preventive impaired availability growth factor...
Neuropathic pain is common in diabetic patients. Degeneration of sensory C-fibers peripheral nerve plays a prominent role the generation neuropathic pain. We examined degenerative changes two rat models with type 1 and 2 diabetes.Type insulinopenic BB/Wor hyperinsulinemic BBZDR/Wor-rats 8 months duration equal exposure to hyperglycemia were examined. Thermal hyperalgesia was monitored using an infrared thermal probe. C-fiber size, number, frequencies denervated Schwann cells, regenerating...
Impaired vascularity and nerve degeneration are the most important pathophysiological abnormalities of diabetic polyneuropathy (DPN). Therefore, regeneration both vascular nervous systems is required for treatment DPN. The neural crest (NC) a transient embryonic structure in vertebrates that differentiates into vast range cells, including peripheral neurons, Schwann smooth muscle cells. In this study, we investigated ability transplantation NC-like (NCL) cells derived from aged mouse induced...
The S100 calcium binding protein B (S100B) implicated in brain inflammation acts via the receptor of advanced glycation end products (RAGE) and is also secreted from adipocytes. We investigated role S100B interaction between adipocytes macrophages using a cell-culture model.RAW264.7 (RAW) were stimulated by recombinant to observe alterations TNF-α M1 markers; 3T3-L1 (L1) examine secretion. RAW L1 then mutually with conditioned media each other, or co-cultured. effects silencing...
Aims/Introduction: Excessive intake of sucrose can cause severe health issues, such as diabetes mellitus. In animal studies, consumption a high-sucrose diet (SUC) has been shown to obesity, insulin resistance and glucose intolerance. However, several in vivo experiments have carried out using diets with much higher contents (50-70% the total calories) than are typically ingested by humans. present study, we examined effects moderate SUC on metabolism underlying mechanism. C57BL/6J mice...
Dental pulp stem cells (DPSCs) can be easily obtained from teeth for general orthodontic reasons. We have previously reported the therapeutic effects of DPSC transplantation diabetic polyneuropathy. As abundant secretomes DPSCs are considered to play a central role in improvement polyneuropathy, we investigated whether direct injection DPSC-conditioned media (DPSC-CM) into hindlimb skeletal muscles ameliorates polyneuropathy rats.DPSCs were isolated dental Sprague-Dawley rats. Eight weeks...
This algorithm was issued for the appropriate use of drugs treatment type 2 diabetes mellitus in Japan. The revisions include safety considerations, fatty liver disease as a comorbidity to be taken into account and position tirzepatide.